scholarly journals Coumadin-induced skin necrosis in a 64 year-old female despite LMWH bridging therapy

2012 ◽  
Vol 13 ◽  
pp. 157-159 ◽  
Author(s):  
Mehandar Kumar ◽  
Vanessa Mae Abrina ◽  
Sasikala Chittimireddy
Keyword(s):  
Skin Necrosis ◽  
Bridging Therapy

scholarly journals A Case Report on Warfarin Induced Skin Necrosis: Drug-drug Interaction or Inappropriate Therapy

2018 ◽  
Vol 4 (1) ◽  
pp. 230-233
Author(s):  
Dutta S ◽  
Sharma PK ◽  
Misra AK ◽  
Kumar R ◽  
Rai S ◽  
...  
Keyword(s):  
Lower Limb ◽  
Skin Necrosis ◽  
Limb Amputation ◽  
Inappropriate Therapy ◽  
Case Description ◽  
Early Complication ◽  
Tissue Necrosis ◽  
Bridging Therapy ◽  
Oral Warfarin ◽  
Skin Discoloration

Introduction: Warfarin is one of the most frequently prescribed oral anticoagulant. Necrosis and/or gangrene ofskin and other tissues is an uncommon but serious risk associated with warfarin. The incidence of warfarin inducedtissue necrosis is about 0.01 % to 0.1%.Case description: A 62-year-old male presented to emergency with a complaint of skin discoloration and edema onleft lower limb diagnosed as warfarin induced skin necrosis. He had an episode of hemiparesis 20 days back for whichhe was started on oral warfarin along with other medications. On diagnosis warfarin was stopped and fresh frozenplasma (FFP) was given along with vitamin K. Due to progressing tissue necrosis, above knee limb amputation wasdone. We assume that an interaction between rosuvastatin and warfarin or possibly lack of adequate bridge therapywith heparin resulted in this complication.Conclusion: Warfarin induced skin necrosis is a known early complication of the therapy. Though late onsetappearance of this event is rare but not unknown. Bridging therapy with heparin and avoiding use of interactingdrugs concomitantly could prevent many such reactions.

scholarly journals Warfarin-Induced Skin Necrosis Despite Enoxaparin Bridging Therapy

Cureus ◽  
2022 ◽  
Author(s):  
Mohamed Wali ◽  
Muhammad T Latif ◽  
Mary Lockwood ◽  
Ayman Saeyeldin ◽  
Carolina Borz-Baba
Keyword(s):  
Skin Necrosis ◽  
Bridging Therapy

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

Repeated Occurrence of Skin Necrosis Twice Following Coumarin Intake and Subsequently During Decrease of Vitamin K Dependent Coagulation Factors Associated with Cholestasis

1982 ◽  
Vol 48 (03) ◽  
pp. 245-246 ◽  
Author(s):  
V Hofmann ◽  
P G Frick
Keyword(s):  
Skin Necrosis ◽  
Oral Anticoagulants ◽  
Subcutaneous Fat ◽  
Coagulation Factors ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Skin Changes ◽  
Factors Associated ◽  
Therapeutic Anticoagulation ◽  
Coumarin Necrosis

SummaryA female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol.Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded.This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy.

Skin necrosis following extravasatin of water soluble contrast media-report of 2 cases

1987 ◽  
Vol 23 (4) ◽  
pp. 658
Author(s):  
J H Park ◽  
S H Kim ◽  
M J Shin ◽  
J C Kim ◽  
K W Minn ◽  
...  
Keyword(s):  
Contrast Media ◽  
Skin Necrosis ◽  
Water Soluble ◽  
Media Report ◽  
Water Soluble Contrast

Consecutive Observation and Treatment of Skin Necrosis due to Extravasation of Mitomycin C.

1999 ◽  
Vol 61 (3) ◽  
pp. 294-297
Author(s):  
Tokuya OSAWA ◽  
Masahiko ISHIHARA ◽  
Toshiyuki AKI ◽  
Reiko URASHIMA ◽  
Motoyuki MIHARA
Keyword(s):  
Mitomycin C ◽  
Skin Necrosis

Rivaroxaban-induced skin necrosis: a case report

2019 ◽  
pp. 112-115
Author(s):  
Mosaad Soliman ◽  
Khaled Mowafy ◽  
Nashaat Elsaadany ◽  
Rana Soliman ◽  
Sameh Awad ◽  
...  
Keyword(s):  
Case Report ◽  
Skin Necrosis

The impact of SPY angiography on intraoperative decision making and outcomes for post-mastectomy reconstruction

2019 ◽  
pp. 1-5
Keyword(s):  
Decision Making ◽  
Logistic Regression ◽  
Skin Necrosis ◽  
Regression Models ◽  
Multivariable Analysis ◽  
P Value ◽  
Flap Necrosis ◽  
Single Institution ◽  
Logistic Regression Models ◽  
The Impact

Objective: While the use of intraoperative laser angiography (SPY) is increasing in mastectomy patients, its impact in the operating room to change the type of reconstruction performed has not been well described. The purpose of this study is to investigate whether SPY angiography influences post-mastectomy reconstruction decisions and outcomes. Methods and materials: A retrospective analysis of mastectomy patients with reconstruction at a single institution was performed from 2015-2017.All patients underwent intraoperative SPY after mastectomy but prior to reconstruction. SPY results were defined as ‘good’, ‘questionable’, ‘bad’, or ‘had skin excised’. Complications within 60 days of surgery were compared between those whose SPY results did not change the type of reconstruction done versus those who did. Preoperative and intraoperative variables were entered into multivariable logistic regression models if significant at the univariate level. A p-value <0.05 was considered significant. Results: 267 mastectomies were identified, 42 underwent a change in the type of planned reconstruction due to intraoperative SPY results. Of the 42 breasts that underwent a change in reconstruction, 6 had a ‘good’ SPY result, 10 ‘questionable’, 25 ‘bad’, and 2 ‘had areas excised’ (p<0.01). After multivariable analysis, predictors of skin necrosis included patients with ‘questionable’ SPY results (p<0.01, OR: 8.1, 95%CI: 2.06 – 32.2) and smokers (p<0.01, OR:5.7, 95%CI: 1.5 – 21.2). Predictors of any complication included a change in reconstruction (p<0.05, OR:4.5, 95%CI: 1.4-14.9) and ‘questionable’ SPY result (p<0.01, OR: 4.4, 95%CI: 1.6-14.9). Conclusion: SPY angiography results strongly influence intraoperative surgical decisions regarding the type of reconstruction performed. Patients most at risk for flap necrosis and complication post-mastectomy are those with questionable SPY results.

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