scholarly journals Effects of Maternal Exposure to Low Doses of DES on Testicular Steroidogenesis and Spermatogenesis in Male Rat Offspring

2009 ◽  
Vol 55 (6) ◽  
pp. 629-637 ◽  
Author(s):  
Tetsuo KOBAYASHI ◽  
Mitsuyuki SHIRAI ◽  
Motoharu SAKAUE ◽  
Masaru MURAKAMI ◽  
Hideharu OCHIAI ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Male Rat ◽  
Low Doses ◽  
Rat Offspring ◽  
Testicular Steroidogenesis

scholarly journals Maternal Exposure to Low Doses of DES Altered mRNA Expression of Hepatic Microsomal Enzymes in Male Rat Offspring

2012 ◽  
Vol 74 (2) ◽  
pp. 247-253
Author(s):  
Osamu NISHIKAWA ◽  
Kazuyoshi ARISHIMA ◽  
Tetsuo KOBAYASHI ◽  
Mitsuyuki SHIRAI ◽  
Masaru MURAKAMI ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Maternal Exposure ◽  
Male Rat ◽  
Low Doses ◽  
Microsomal Enzymes ◽  
Rat Offspring ◽  
Hepatic Microsomal Enzymes

Can maternal exposure to paracetamol impair reproductive parameters of male rat offspring?

2020 ◽  
Vol 93 ◽  
pp. 68-74
Author(s):  
Marina Rangel Ferro Pereira ◽  
Jeberson Fernando Aleixo ◽  
Liara de Freitas Cavalcanti ◽  
Nathalia Orlandini Costa ◽  
Milene Leivas Vieira ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Male Rat ◽  
Reproductive Parameters ◽  
Rat Offspring

scholarly journals Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Caroline Serrano-Nascimento ◽  
Rafael Barrera Salgueiro ◽  
Thiago Pantaleão ◽  
Vânia Maria Corrêa da Costa ◽  
Maria Tereza Nunes
Keyword(s):  
Adult Male ◽  
Maternal Exposure ◽  
Male Rat ◽  
Iodine Excess ◽  
Rat Offspring ◽  
Adult Male Rat ◽  
Pregnancy And Lactation

Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring

2016 ◽  
Vol 61 ◽  
pp. 169-176 ◽  
Author(s):  
Yi-Ping Zhu ◽  
En-Hui Li ◽  
Wen-Lan Sun ◽  
Dong-Liang Xu ◽  
Zhi-Hong Liu ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Male Rat ◽  
Rat Offspring ◽  
Butyl Phthalate

Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus

2021 ◽  
pp. 074823372098462
Author(s):  
Chong Wang ◽  
Yao Shu ◽  
Li Xu ◽  
Qiling Liu ◽  
Bei Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Learning And Memory ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Male Rat ◽  
Control Group ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that N-methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. In this study, BPA was administered to female Sprague–Dawley rats (six per dose group) at concentrations of 0 (control), 4, 40, and 400 μg/kg·body weight/day from gestation day 1 through lactation day 21. Spatial learning was evaluated using the Morris water maze on postnatal day 22. Expression levels of NMDARs were determined using real-time polymerase chain reaction and Western blot. The results showed that male offspring exposed to BPA exhibited increased latency in reaching the platform and reduced time in the target quadrant, and the number of crossing the platform was less, as compared with the control group. The mRNA and protein expression levels of NMDARs in the hippocampus were significantly downregulated when compared with the control group of male offspring. The data showed that maternal exposure to BPA at low dosage can cause cognitive deficits in male rat offspring, probably due to a decrease in NMDARs in the hippocampus.

Maternal exposure to picrotoxin modifies the response of the GABAA receptor during sexual behavior of adult male rat offspring

2012 ◽  
Vol 23 (7) ◽  
pp. 703-709 ◽  
Author(s):  
Maria M. Bernardi ◽  
Thiago B. Kirsten ◽  
Elizabeth Teodorov ◽  
Ana C.Z. Baso ◽  
Fabio C. Prosdocimi ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Gabaa Receptor ◽  
Adult Male ◽  
Maternal Exposure ◽  
Male Rat ◽  
Rat Offspring ◽  
Adult Male Rat

scholarly journals Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol

2019 ◽  
Vol 20 (18) ◽  
pp. 4382 ◽  
Author(s):  
Chien-Ning Hsu ◽  
Yu-Ju Lin ◽  
You-Lin Tain
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Adult Male ◽  
Endocrine Disrupting Chemicals ◽  
Maternal Exposure ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
No Bioavailability

Maternal exposure to endocrine disrupting chemicals (EDCs) and a high-fat intake may induce the developmental programming of hypertension in adult offspring. Bisphenol A (BPA) is one of the most commonly environmental EDCs. As the nitric oxide (NO) and aryl hydrocarbon receptor (AHR) signaling pathways both contribute to the pathogenesis of hypertension, we evaluated whether resveratrol, an antioxidant and an AHR antagonist, can prevent hypertension programmed by a maternal BPA and HF diet. Sixteen-week-old male rat offspring were assigned to six groups (n = 8 per group): Control, HF (D12331, Research Diets), BPA (50 μg/kg/day), HF + BPA, BPA + R (resveratrol 50mg/L in drinking water throughout pregnancy and lactation), and HF + BPA + R. Maternal BPA exposure exacerbated hypertension programmed by HF consumption in adult male offspring, which was protected by maternal resveratrol therapy. The BPA and HF diet synergistically induced oxidative stress in offspring kidneys, which resveratrol treatment prevented. We observed that HF + BPA-induced programmed hypertension was associated with a decreased NO bioavailability, increased oxidative stress, and an activated AHR signaling pathway. The beneficial effects of resveratrol are relevant to restoring NO bioavailability, reducing oxidative stress, and antagonizing the AHR signaling pathway. Our results cast a new light on resveratrol as a reprogramming strategy to protect against hypertension programmed by combined BPA and HF exposure, but this strategy has yet to be translated into clinical applications.

scholarly journals Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di- n -butyl-phthalate (DBP)

2017 ◽  
Vol 69 ◽  
pp. 254-264 ◽  
Author(s):  
Talita de Mello Santos ◽  
Lívia Teresa Ribeiro da Silveira ◽  
Jaqueline Carvalho Rinaldi ◽  
Wellerson Rodrigo Scarano ◽  
Raquel Fantin Domeniconi
Keyword(s):  
Maternal Exposure ◽  
Male Rat ◽  
Rat Offspring ◽  
Butyl Phthalate

scholarly journals Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring

2020 ◽  
Vol 139 ◽  
pp. 111256 ◽  
Author(s):  
Elga Schreiber ◽  
Tània Garcia ◽  
Neus González ◽  
Roser Esplugas ◽  
Raju Prasad Sharma ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Male Rat ◽  
Rat Offspring
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