scholarly journals Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol

2019 ◽  
Vol 20 (18) ◽  
pp. 4382 ◽  
Author(s):  
Chien-Ning Hsu ◽  
Yu-Ju Lin ◽  
You-Lin Tain
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Adult Male ◽  
Endocrine Disrupting Chemicals ◽  
Maternal Exposure ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
No Bioavailability

Maternal exposure to endocrine disrupting chemicals (EDCs) and a high-fat intake may induce the developmental programming of hypertension in adult offspring. Bisphenol A (BPA) is one of the most commonly environmental EDCs. As the nitric oxide (NO) and aryl hydrocarbon receptor (AHR) signaling pathways both contribute to the pathogenesis of hypertension, we evaluated whether resveratrol, an antioxidant and an AHR antagonist, can prevent hypertension programmed by a maternal BPA and HF diet. Sixteen-week-old male rat offspring were assigned to six groups (n = 8 per group): Control, HF (D12331, Research Diets), BPA (50 μg/kg/day), HF + BPA, BPA + R (resveratrol 50mg/L in drinking water throughout pregnancy and lactation), and HF + BPA + R. Maternal BPA exposure exacerbated hypertension programmed by HF consumption in adult male offspring, which was protected by maternal resveratrol therapy. The BPA and HF diet synergistically induced oxidative stress in offspring kidneys, which resveratrol treatment prevented. We observed that HF + BPA-induced programmed hypertension was associated with a decreased NO bioavailability, increased oxidative stress, and an activated AHR signaling pathway. The beneficial effects of resveratrol are relevant to restoring NO bioavailability, reducing oxidative stress, and antagonizing the AHR signaling pathway. Our results cast a new light on resveratrol as a reprogramming strategy to protect against hypertension programmed by combined BPA and HF exposure, but this strategy has yet to be translated into clinical applications.

scholarly journals Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Caroline Serrano-Nascimento ◽  
Rafael Barrera Salgueiro ◽  
Thiago Pantaleão ◽  
Vânia Maria Corrêa da Costa ◽  
Maria Tereza Nunes
Keyword(s):  
Adult Male ◽  
Maternal Exposure ◽  
Male Rat ◽  
Iodine Excess ◽  
Rat Offspring ◽  
Adult Male Rat ◽  
Pregnancy And Lactation

scholarly journals Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced Programmed Hypertension in Male Rat Offspring

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yu-Ju Lin ◽  
I-Chun Lin ◽  
Hong-Ren Yu ◽  
Jiunn-Ming Sheen ◽  
Li-Tung Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dimethyl Fumarate ◽  
Nutrient Sensing ◽  
Male Rat ◽  
Related Factor ◽  
High Fat ◽  
Antenatal Corticosteroids ◽  
Rat Offspring ◽  
Nrf2 Signaling Pathway ◽  
The Impact

Prenatal dexamethasone (DEX) exposure, postnatal high-fat (HF) intake, and oxidative stress are closely related to the development of hypertension. Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates oxidative stress. Dimethyl fumarate (DMF) reportedly activates Nrf2 and protects against oxidative stress damage. We examined a 4-month-old male rat offspring from five groups (n=8 for each group): control, DEX (0.1 mg/kg i.p. from a gestational age of 16 to 22 days), HF (D12331 diet from weaning to 4 months of age), and DEX + HF, DEX + HF + DMF (50 mg/kg/day via gastric gavage for 3 weeks after weaning). We found that postnatal HF intake aggravated prenatal DEX-induced hypertension in adult male offspring, which could be prevented by DMF treatment. The beneficial effects of DMF treatment include an increase in renal Nrf2 gene expression, reduction of oxidative stress, decrease in plasma asymmetric dimethylarginine (ADMA) and renal soluble epoxide hydrolase protein levels, increase in the L-arginine-to-ADMA ratio, and activation of genes related to nutrient sensing and autophagy (e.g., Pparb, Pparg, Ppargc1a, Ulk1, and Atg5). In conclusion, better understanding of the impact of the Nrf2 signaling pathway in the two-hit model will aid in protecting children exposed to antenatal corticosteroids and a postnatal HF diet from programmed hypertension.

scholarly journals Maternal High-Fat and High-Salt Diets Have Differential Programming Effects on Metabolism in Adult Male Rat Offspring

2018 ◽  
Vol 5 ◽  
Author(s):  
Stephanie A. Segovia ◽  
Mark H. Vickers ◽  
Claudia J. Harrison ◽  
Rachna Patel ◽  
Clint Gray ◽  
...  
Keyword(s):  
Adult Male ◽  
High Salt ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
Adult Male Rat

Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus

2021 ◽  
pp. 074823372098462
Author(s):  
Chong Wang ◽  
Yao Shu ◽  
Li Xu ◽  
Qiling Liu ◽  
Bei Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Learning And Memory ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Male Rat ◽  
Control Group ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that N-methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. In this study, BPA was administered to female Sprague–Dawley rats (six per dose group) at concentrations of 0 (control), 4, 40, and 400 μg/kg·body weight/day from gestation day 1 through lactation day 21. Spatial learning was evaluated using the Morris water maze on postnatal day 22. Expression levels of NMDARs were determined using real-time polymerase chain reaction and Western blot. The results showed that male offspring exposed to BPA exhibited increased latency in reaching the platform and reduced time in the target quadrant, and the number of crossing the platform was less, as compared with the control group. The mRNA and protein expression levels of NMDARs in the hippocampus were significantly downregulated when compared with the control group of male offspring. The data showed that maternal exposure to BPA at low dosage can cause cognitive deficits in male rat offspring, probably due to a decrease in NMDARs in the hippocampus.

Maternal exposure to picrotoxin modifies the response of the GABAA receptor during sexual behavior of adult male rat offspring

2012 ◽  
Vol 23 (7) ◽  
pp. 703-709 ◽  
Author(s):  
Maria M. Bernardi ◽  
Thiago B. Kirsten ◽  
Elizabeth Teodorov ◽  
Ana C.Z. Baso ◽  
Fabio C. Prosdocimi ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Gabaa Receptor ◽  
Adult Male ◽  
Maternal Exposure ◽  
Male Rat ◽  
Rat Offspring ◽  
Adult Male Rat

scholarly journals Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy

2019 ◽  
Vol 20 (16) ◽  
pp. 3957 ◽  
Author(s):  
Chien-Ning Hsu ◽  
Yu-Ju Lin ◽  
Hong-Ren Yu ◽  
I-Chun Lin ◽  
Jiunn-Ming Sheen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dimethyl Fumarate ◽  
Nutrient Sensing ◽  
Male Rat ◽  
Adult Offspring ◽  
Related Factor ◽  
High Fat ◽  
Male Adult ◽  
Rat Offspring ◽  
Nrf2 Signaling Pathway

Hypertension can originate from early-life exposure to oxidative stress. As reported, dimethyl fumarate (DMF) activates nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and protects against oxidative stress damage. We examined whether maternal DMF therapy protects adult offspring against hypertension programmed by prenatal dexamethasone (DEX) and postnatal high-fat (HF) diet exposure. We examined male Sprague Dawley rat offspring at 4 months of age from five groups (n = 11–13/group): control, DEX (0.1mg/kg i.p. from gestational day 16 to 22), HF (D12331 diet from weaning to 16 weeks of age), DEX+HF, and DEX+HF+DMF (50mg/kg/day via gastric gavage for 3 weeks during pregnancy). Maternal DMF therapy prevented male offspring against hypertension programmed by combined DEX and HF exposures. The protective effects of maternal DMF include reduced oxidative stress, decreased plasma asymmetric dimethylarginine (ADMA) levels, downregulated the renin-angiotensin system (i.e. Ren, Agt, Ace, and Agtr1a), increased renal protein levels of certain nutrient-sensing signals, and promoted autophagy. In conclusion, maternal Nrf2 activation by DMF protects male adult offspring against hypertension programmed by combined DEX and HF exposures. Our results cast a new light on the therapeutic potential of targeting Nrf2 signaling pathway as reprogramming strategies to prevent programmed hypertension in children exposed to antenatal corticosteroids and postnatally excessive consumption of fat.

Maternal conjugated linoleic acid consumption prevented TAG alterations induced by a high-fat diet in male adult rat offspring

2020 ◽  
Vol 124 (3) ◽  
pp. 286-295
Author(s):  
Marcela Aída González ◽  
Jimena Lavandera ◽  
Carolina Gerstner ◽  
Ana Clara Fariña ◽  
Juliana Saín ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Adult Male ◽  
Liver Steatosis ◽  
Male Offspring ◽  
Male Rat ◽  
High Fat ◽  
Male Adult ◽  
Hepatic Lipid ◽  
Rat Offspring

AbstractMaternal nutritional programming by a high-fat (HF) diet is related to hepatic lipid accumulation and steatosis in offspring. Conjugated linoleic acid (CLA) might ameliorate impaired hepatic lipid homoeostasis; therefore, the aim was to investigate the potential preventive effect of maternal CLA consumption on TAG metabolism alterations induced by HF diets in adult male rat offspring receiving or not receiving CLA. Female Wistar rats were fed a control (C) diet, HF diet or HF diet supplemented with CLA (HF+CLA) for 4 weeks before mating and throughout pregnancy and lactation. After weaning, for 9 weeks, male offspring of C or HF rats continued with the same diets as their mothers (C/C or HF/HF groups, respectively) and male offspring of HF+CLA rats were fed HF or HF+CLA diets (HF+CLA/HF or HF+CLA/HF+CLA groups, respectively). Nutritional parameters, serum and liver TAG levels, the TAG secretion rate (TAG-SR) and the activities as well as gene expression of key hepatic enzymes involved in TAG regulation were assessed. The most interesting results were that maternal CLA decreased epididymal white adipose tissue weight and prevented serum and liver TAG accumulation induced by a HF diet in adult male offspring receiving or not receiving CLA. The prevention of liver steatosis in HF+CLA/HF+CLA and HF+CLA/HF offspring was associated with an increased hepatic TAG-SR. Overall, this study provides evidence that maternal CLA consumption programmes TAG regulation and in this way contributes to lowering lipid levels in tissues and preventing liver steatosis in particular.

Maternal exposure to high-fat and high-cholesterol diet induces arterial hypertension and oxidative stress along the gut-kidney axis in rat offspring

Life Sciences ◽  
2020 ◽  
Vol 261 ◽  
pp. 118367
Author(s):  
Luciana Caroline Paulino do Nascimento ◽  
José Patrocínio Ribeiro Cruz Neto ◽  
Valdir de Andrade Braga ◽  
Claudia Jacques Lagranha ◽  
José Luiz de Brito Alves
Keyword(s):  
Oxidative Stress ◽  
Arterial Hypertension ◽  
Maternal Exposure ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Rat Offspring ◽  
And Oxidative Stress
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