scholarly journals Effect of Pueraria mirifica on the Sexual Skin Coloration of Aged Menopausal Cynomolgus Monkeys

2006 ◽  
Vol 52 (4) ◽  
pp. 537-542 ◽  
Author(s):  
Hataitip TRISOMBOON ◽  
Suchinda MALAIVIJITNOND ◽  
Wichai CHERDSHEWASART ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA
Keyword(s):  
Pueraria Mirifica ◽  
Cynomolgus Monkeys ◽  
Sexual Skin ◽  
Skin Coloration

scholarly journals Long-Term Treatment Effects of Pueraria mirifica Phytoestrogens on Parathyroid Hormone and Calcium Levels in Aged Menopausal Cynomolgus Monkeys

2004 ◽  
Vol 50 (6) ◽  
pp. 639-645 ◽  
Author(s):  
Hataitip TRISOMBOON ◽  
Suchinda MALAIVIJITNOND ◽  
Juri SUZUKI ◽  
Yuzuru HAMADA ◽  
Gen WATANABE ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Treatment Effects ◽  
Term Treatment ◽  
Pueraria Mirifica ◽  
Cynomolgus Monkeys ◽  
Long Term Treatment

scholarly journals Assessment of Urinary Gonadotropin and Steroid Hormone Profiles of Female Cynomolgus Monkeys after Treatment with Pueraria mirifica

2007 ◽  
Vol 53 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Hataitip TRISOMBOON ◽  
Suchinda MALAIVIJITNOND ◽  
Wichai CHERDSHEWASART ◽  
Gen WATANABE ◽  
Kazuyoshi TAYA
Keyword(s):  
Steroid Hormone ◽  
Pueraria Mirifica ◽  
Cynomolgus Monkeys

scholarly journals Comparative Pharmacokinetics of Puerarin Alone and in Pueraria mirifica Extract in Female Cynomolgus Monkeys

Planta Medica ◽  
2020 ◽  
Author(s):  
Sureerat Namken ◽  
Phanit Songvut ◽  
Nitra Nuengchamnong ◽  
Taratorn Kemthong ◽  
Phisit Khemawoot ◽  
...  
Keyword(s):  
Normal Range ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Pueraria Mirifica ◽  
Cynomolgus Monkeys ◽  
Pharmacokinetic Profiles ◽  
Liquid Chromatography Tandem Mass ◽  
Absolute Oral Bioavailability ◽  
Human Use

Abstract Pueraria mirifica is an endemic Thai plant that has been used for rejuvenation and in the relief of various aging diseases. Puerarin is one of the major isoflavones found in this plant and shows several pharmacological activities in relation to the Thai traditional use of P. mirifica. Therefore, comparative pharmacokinetics of pure puerarin alone and that in a P. mirifica extract in cynomolgus monkeys were conducted in order to investigate the pharmacokinetic profiles of the 2 preparations. To this end, puerarin and P. mirifica extract, at an equivalent dose of 10 mg/kg of puerarin, were orally dosed to adult female monkeys for 7 consecutive days. A single intravenous injection of puerarin at a dose of 1 mg/kg was also peformed. Serial blood samples and excreta were collected from 0 – 24 h and 0 – 48 h after dosing. Determination of the puerarin levels and its metabolites in biological samples was conducted by liquid chromatography tandem mass spectrometry. Plasma levels of aspartate aminotransferase, alanine aminotransferase, and creatinine fluctuated in the normal range, with no abnormal physical signs in the animal. The absolute oral bioavailability of puerarin was approximately 1% in both preparations. Accumulation of puerarin was found after oral dosing for 7 consecutive days in both groups. Major metabolites of puerarin found in monkeys were hydroxylation and deglycosylation products. A negligible amount of unchanged puerarin was detected in urine and feces. Pharmacokinetic profiles obtained from this study could help to design the prescribed remedy of puerarin and P. mirifica extract phytopharmaceutical products for human use.

Hexachlorobenzene toxicity in the monkey ovary: III. Ultrastructure induced by high (10 mg/kg) dose exposure

1991 ◽  
Vol 49 ◽  
pp. 130-131
Author(s):  
A. Singh ◽  
A. Dykeman ◽  
J. Jarrelf ◽  
D. C. Villeneuve
Keyword(s):  
Present Report ◽  
Reproductive Toxicity ◽  
Control Group ◽  
Primate Model ◽  
Human Follicular Fluid ◽  
Thin Sections ◽  
Cynomolgus Monkeys ◽  
Cacodylate Buffer ◽  
Induction Cycle ◽  
Comprehensive Study

Hexachlorobenzene (HCB), a persistent and mobile organochlorine pesticide, occurs in environment. HCB has been shown to be present in human follicular fluid. An objective of the present report, which is part of a comprehensive study on reproductive toxicity of HCB, was to determine the cytologic effects of the compound on ovarian follicles in a primate model.Materials and Methods. Eight Cynomolgus monkeys were housed under controlled conditions at Animal facility of Health and Welfare, Ottawa. Animals were orally administered gelatin capsules containing HCB mixed with glucose in daily dosages of 0.0 or 10 mg/kg b.w. for 90 days; the former was the control group. On the menstrual period following completion of dosing, the monkeys underwent an induction cycle of superovulation. At necropsy, one-half of an ovary from each animal was diced into ca. 2- to 3-mm cubed specimens that were fixed by immersion in 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.3). Subsequent procedures followed to obtain thin sections that were examined in a Hitachi H-7000 electron microscope have been described earlier.

Hemodynamic effects of induced fetal anemia in cynomolgus monkeys

1998 ◽  
Vol 5 (1) ◽  
pp. 159A-159A
Author(s):  
W BLOCK ◽  
M OSULLIVAN ◽  
N SMITH ◽  
M DRAPER ◽  
C MIRABILE ◽  
...  
Keyword(s):  
Fetal Anemia ◽  
Hemodynamic Effects ◽  
Cynomolgus Monkeys

Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen

Reproduction ◽  
2000 ◽  
pp. 19-32 ◽  
Author(s):  
ML Martinez ◽  
JD Harris
Keyword(s):  
Menstrual Cycle ◽  
Recombinant Protein ◽  
Antibody Titre ◽  
Zona Pellucida ◽  
Protein A ◽  
Papio Cynocephalus ◽  
Cynomolgus Monkeys ◽  
Menstrual Cycles ◽  
Normal Menstrual Cycle

Immunization of female mammals with native zona pellucida (ZP) proteins is known to cause infertility. Since each human ZP protein is now available as a purified recombinant protein, is it possible to compare the immunocontraceptive potential of each ZP protein. A breeding study was conducted in cynomolgus monkeys (Macaca fasicularis) after immunization with recombinant human ZP (rhZP) proteins (ZPA, ZPB, ZPC) separately and in combinations. This study demonstrated that immunization with recombinant human ZPB (rhZPB) protein caused cynomolgus monkeys to become infertile for 9-35 months. A second study was conducted in baboons (Papio cynocephalus), which yielded a similar result. The baboons immunized with rhZPB became infertile for 9 to > 20 months. During the time of maximum antibody titre, some animals experienced disruption of the menstrual cycle, but eventually all of the animals resumed normal menstrual cycles. Control animals and animals immunized with other rhZP proteins all became pregnant before any of the rhZPB-treated animals. This is the first study in which a recombinant ZP protein has consistently induced infertility in a primate without permanent disruption of the normal menstrual cycle.

Generation of GFP transgenic cynomolgus monkeys

2016 ◽  
Author(s):  
Yasunari Seita ◽  
Tomonori Tsukiyama ◽  
Chizuru Iwatani ◽  
Hideaki Tsuchiya ◽  
Jun Matsushita ◽  
...  
Keyword(s):  
Cynomolgus Monkeys
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