scholarly journals Effects of Exposure In Utero to Bisphenol A on the Expression of Aryl Hydrocarbon Receptor, Related Factors, and Xenobiotic Metabolizing Enzymes in Murine Embryos

2005 ◽  
Vol 51 (5) ◽  
pp. 593-605 ◽  
Author(s):  
Hanako NISHIZAWA ◽  
Satoshi IMANISHI ◽  
Noboru MANABE
Keyword(s):  
Bisphenol A ◽  
Aryl Hydrocarbon Receptor ◽  
In Utero ◽  
Related Factors ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Aryl Hydrocarbon ◽  
Murine Embryos

scholarly journals Fungal natural alkaloid schizocommunin activates the aryl hydrocarbon receptor pathway

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 985-990
Author(s):  
Roxana Filip ◽  
Tyler A. Shaw ◽  
Atsushi Nishida ◽  
John Paul Pezacki
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Aryl Hydrocarbon ◽  
Natural Alkaloid

Activation of AhR by schizocommunin is linked to increased expression of xenobiotic metabolizing enzymes associated with immune and allergic responses.

scholarly journals In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor

2006 ◽  
Vol 66 (2) ◽  
pp. 755-762 ◽  
Author(s):  
Zhen Yu ◽  
Christiane V. Loehr ◽  
Kay A. Fischer ◽  
Mandy A. Louderback ◽  
Sharon K. Krueger ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
In Utero ◽  
In Utero Exposure ◽  
Aryl Hydrocarbon

scholarly journals Effects of In Utero Exposure to Bisphenol A on Expression of RARα and RXRα mRNAs in Murine Embryos

2003 ◽  
Vol 49 (6) ◽  
pp. 539-545 ◽  
Author(s):  
Hanako NISHIZAWA ◽  
Noboru MANABE ◽  
Maki MORITA ◽  
Miki SUGIMOTO ◽  
Satoshi IMANISHI ◽  
...  
Keyword(s):  
Bisphenol A ◽  
In Utero ◽  
In Utero Exposure ◽  
Murine Embryos

scholarly journals Dopamine is an aryl hydrocarbon receptor agonist

2020 ◽  
Vol 477 (19) ◽  
pp. 3899-3910
Author(s):  
Hyejin Park ◽  
Un-ho Jin ◽  
Keshav Karki ◽  
Arul Jayaraman ◽  
Clint Allred ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Aryl Hydrocarbon Receptor ◽  
Cancer Cells ◽  
Agonist Activity ◽  
Metabolizing Enzymes ◽  
Aryl Hydrocarbon ◽  
Pancreatic Cancer Cells ◽  
Aryl Hydrocarbon Receptor Agonist ◽  
Tryptophan Metabolites ◽  
High Concentrations

Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and carbidopa, a drug used in treating Parkinson's disease, activated the AhR. In this study, we identified the neuroactive hormone dopamine as an inducer of drug-metabolizing enzymes CYP1A1, CYP1B1, and UGT1A1 in colon and glioblastoma cells and similar results were observed for carbidopa. In contrast, carbidopa but not dopamine exhibited AhR activity in BxPC3 pancreatic cancer cells whereas minimal activity was observed for both compounds in Panc1 pancreatic cancer cells. In contrast with a previous report, the induction responses and cytotoxicity of carbidopa was observed only at high concentrations (100 µM) in BxPC3 cells. Our results show that similar to serotonin and several tryptophan metabolites, dopamine is also an AhR-active compound.

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