scholarly journals Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver

2013 ◽  
Vol 55 (3) ◽  
pp. 184-195 ◽  
Author(s):  
Muna S. Nahar ◽  
Jung H. Kim ◽  
Maureen A. Sartor ◽  
Dana C. Dolinoy
Keyword(s):  
Bisphenol A ◽  
Epigenetic Regulation ◽  
Fetal Liver ◽  
Metabolizing Enzymes ◽  
Human Fetal Liver ◽  
Xenobiotic Metabolizing Enzymes ◽  
Genes Encoding

Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes in a Brazilian population

Biomarkers ◽  
2009 ◽  
Vol 14 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Vanessa Da Silva Silveira ◽  
Renata Canalle ◽  
Carlos Alberto Scrideli ◽  
Rosane Gomes de Paula Queiroz ◽  
Luiz Gonzaga Tone
Keyword(s):  
Brazilian Population ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Genes Encoding

QUANTIFICATION OF FREE AND CONJUGATED BISPHENOL A IN HUMAN FETAL LIVER TISSUE

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Muna Nahar ◽  
Chunyang Liao ◽  
Kurunthachalam Kannan ◽  
Laura Rozek ◽  
Dana Dolinoy
Keyword(s):  
Bisphenol A ◽  
Liver Tissue ◽  
Fetal Liver ◽  
Human Fetal Liver

scholarly journals Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin

Planta Medica ◽  
2018 ◽  
Vol 85 (01) ◽  
pp. 6-13
Author(s):  
Sameega Abrahams ◽  
Sedicka Samodien ◽  
Mariska Lilly ◽  
Elizabeth Joubert ◽  
Wentzel Gelderblom
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Tissue Type ◽  
Differential Modulation ◽  
Primary Hepatocytes ◽  
Glutathione S Transferase ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Genes Encoding

AbstractModulation of the expression of hepatic and renal genes encoding xenobiotic metabolizing enzymes by an aspalathin-enriched green rooibos (Aspalathus linearis) extract (GRE) was investigated in the liver and kidneys of F344 rats following dietary exposure of 28 d, as well as selected xenobiotic metabolizing genes in rat primary hepatocytes. In the liver, GRE upregulated genes (p < 0.05) encoding aldehyde dehydrogenase, glucose phosphate isomerase, and cytochrome P450 while 17β-hydroxysteroid dehydrogenase 2 (Hsd17β2) was downregulated. In primary hepatocytes, GRE lacked any effect, while aspalathin downregulated Hsd17β2, mimicking the effect of GRE in vivo, and upregulated catechol-O-methyl transferase and marginally (p < 0.1) cytochrome P450 2e1. In the kidneys, GRE upregulated (p < 0.05) genes encoding the phase II xenobiotic metabolism enzymes, glutathione-S-transferase mµ and microsomal glutathione-S-transferase, while downregulating genes encoding the ATP binding cassette transporter, cytochrome P450, gamma glutamyltransferase 1, and N-acetyltransferase 1. Differential modulation of the expression of xenobiotic metabolizing genes in vivo and in vitro by GRE is dose-related, duration of exposure, the tissue type, and interactions between specific polyphenol and/or combinations thereof. Aspalathin is likely to be responsible for the downregulation of estradiol and testosterone catabolism by GRE in the liver. The differential gene expression by GRE in the liver and kidneys could, depending on the duration exposure and dose utilized, determine the safe use of such an extract in humans for specific health and/or disease outcomes.

scholarly journals Polymorphism in genes encoding xenobiotic-metabolizing enzymes (GSTM1 and GSTT1) and the risk of asthma onset in Moldovan and other ethnic groups: a meta-analysis

2014 ◽  
Vol 11 (1) ◽  
pp. 39-44
Author(s):  
L V Vasilos ◽  
O N Kyrstya ◽  
T E Ivashchenko ◽  
A N Kozhokaru ◽  
M V Aseyev ◽  
...  
Keyword(s):  
Ethnic Groups ◽  
Meta Analysis ◽  
Cumulative Risk ◽  
Fold Increase ◽  
Published Data ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Increased Risk ◽  
Genes Encoding ◽  
Risk Of Disease

Background. The aim of the study was to examine the association of the risk of asthma onset with polymorphisms in genes encoding proteins xenobiotic metabolizing enzymes (GSTT1 and GSTM1) in Moldovans and other ethnic groups using the meta-analysis method. Methods. A meta-analysis of the association of genetic polymorphism of GSTT1 and GSTM1 genes and the risk of asthma development in 180 Moldovan subjects in comparison with published data on various ethnogeographical affiliations was performed. Results. The meta-analysis results were based on sixteen studies which included a total number of 3873 patients and 4863 healthy individuals. The meta-analysis showed an increased risk of disease development in subjects who are carriers of the GSTM1 null genotype (odds ratio of the cumulative risk was 1,29; 95% CI 1,09-1,54), whereas the GSTT1 0/0 genotype was associated with a 1,32 fold increase of the cumulative risk of asthma onset (95% CI 0,99-1,75). Conclusion. The obtained results suggest that the risk of asthma development is associated with the deletion polymorphism in genes encoding proteins xenobiotic metabolizing enzymes (GSTT1 and GSTM1), but the mechanisms of the disease also depend on the gene-by-gene and gene-environment interactions.

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