scholarly journals How should we use imaging in the determination of brainstem death?

BJR|Open ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 20180013
Author(s):  
Sanjeev Ramachandran ◽  
Harish Venkatesh ◽  
Robert William Foley
Keyword(s):  
Critical Care ◽  
Brainstem Death ◽  
Irreversible Brain Damage ◽  
The World ◽  
Brainstem Function ◽  
Ancillary Studies ◽  
Irreversible Cessation ◽  
Key Questions

Brainstem death is defined as the “irreversible cessation of brainstem function”, either due to primary intracranial events or extracranial factors such as hypoxia. The importance of accurate and timely diagnosis of brainstem death in critical care should not be understated, as it allows the withdrawal of treatment when it is no longer deemed to beneficial. Additionally, it may facilitate the process of organ donation. Overall, the diagnosis of brainstem death has four common principles across the world: (1) neurological criteria based on clinical assessment; (2) evidence of irreversible brain damage from known aetiology; (3) demonstrating an absence of a reversible cause; and (4) the use of ancillary studies. The latter in particular has been a controversial issue, with much debate continuing on how imaging should be used. We discuss three key questions surrounding the role of imaging in the diagnosis of brainstem death as well as important issues the radiology community should consider.

scholarly journals Demographic science aids in understanding the spread and fatality rates of COVID-19

2020 ◽  
Vol 117 (18) ◽  
pp. 9696-9698 ◽  
Author(s):  
Jennifer Beam Dowd ◽  
Liliana Andriano ◽  
David M. Brazel ◽  
Valentina Rotondi ◽  
Per Block ◽  
...  
Keyword(s):  
Critical Care ◽  
South Korea ◽  
Age Structure ◽  
Care Needs ◽  
Age Composition ◽  
The World ◽  
Specific Mortality ◽  
Population Sizes ◽  
Age And Sex

Governments around the world must rapidly mobilize and make difficult policy decisions to mitigate the coronavirus disease 2019 (COVID-19) pandemic. Because deaths have been concentrated at older ages, we highlight the important role of demography, particularly, how the age structure of a population may help explain differences in fatality rates across countries and how transmission unfolds. We examine the role of age structure in deaths thus far in Italy and South Korea and illustrate how the pandemic could unfold in populations with similar population sizes but different age structures, showing a dramatically higher burden of mortality in countries with older versus younger populations. This powerful interaction of demography and current age-specific mortality for COVID-19 suggests that social distancing and other policies to slow transmission should consider the age composition of local and national contexts as well as intergenerational interactions. We also call for countries to provide case and fatality data disaggregated by age and sex to improve real-time targeted forecasting of hospitalization and critical care needs.

scholarly journals Prophetic Sira and the Construction of Indonesian Islam

2021 ◽  
Vol 4 (1) ◽  
pp. 88-105
Author(s):  
Muhammad Abdul Karim
Keyword(s):  
The Other ◽  
Cultural Complexity ◽  
Modes Of Transmission ◽  
Indonesian Archipelago ◽  
The World ◽  
The Face

Indonesian Islam has gone through a long journey in its history since the first advent up to the present day. In this course, one should note that the process of Islamization was formed under a set of historical and cultural complexity. Among those, the role of Islamic preaching is the most important. Under this canopy, the process of transmission and transformation took the first place as the main force. As the Qur’an and Sunna are the major sources for all Muslims around the world. Both had also become the main streams in Islamicization. Seerat-e-nabi, beside the Qur’an, in this case has a place of honor. It became one of the major sources of all Islamic heritages in Indonesia. The prophet Muhammad PBUH (peace be upon him) was immersed within the Indonesian Islamic traditions in various fields and spheres. It is fair to say that the story of the islamicization of the Indonesian archipelago and the face of Indonesian Islam today is culturally formed by the determination of seerat-e-nabi, besides the Qur’anic scripture. In the other words, the birth and the face of Islam really depend on how its adherents interpret and take a cultural reception on the seerat-e-nabi. This paper tries to capture the prophetic heritage in Indonesian Islam in twofold analysis; transmission and transformation. The former tries to explore how the heritage of seerat-e-nabi flowed into the scene of Indonesian moslem life through various modes of transmission up to the present day. The latter aims at how the seerat-e-nabi became the force and inspiration for the various receptions of institutional matters.    

scholarly journals TEACHER'S READINESS FOR FORMATION OF CIVIL IDENTITY OF SCHOOL STUDENTS AND PATRIOTIC EDUCATION

2018 ◽  
Vol 2 ◽  
pp. 5
Author(s):  
Tatyana Bugachuk ◽  
Olga Koryakovtseva
Keyword(s):  
Social Order ◽  
Civic Identity ◽  
Educational Organizations ◽  
School Students ◽  
World Community ◽  
The World ◽  
Patriotic Education ◽  
Role Of Teachers

The article deals with the actual question of the role of teachers in the patriotic education and the formation of students' civic identity. The authors of the article presented the results of a study on the determination of teachers' readiness for the formation of civic identity and patriotic education of schoolchildren, which was carried out using the author’s questionnaire and as a result of which the authors came to a contradiction about the need to educate patriots at a higher, qualitatively new level in accordance with social order and lack the readiness of teachers of general educational organizations to patriotic education in new conditions. Emphasis is placed on the organization of systematic work on the training of teachers of general educational organizations for patriotic education and the formation of the civic identity of schoolchildren in the new conditions for the development of the world community.

Role of Plasma miRNA-501 Expression Profile as a Marker of Hepatocellular Carcinoma (HCC) Progression With Hepatitis C Virus Infection

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S134-S134
Author(s):  
Mohamed Shedid ◽  
Mohamed Abdelmonem ◽  
Ayman Boraik ◽  
Alaa Elmetwalli ◽  
Ahmed Esmael
Keyword(s):  
Rna Extraction ◽  
Control Group ◽  
Hepatitis C Virus Infection ◽  
Rt Pcr ◽  
The World ◽  
Noninvasive Biomarker ◽  
Biological Aspects ◽  
Plasma Mirna

Abstract Introduction HCV is a health problem that confronts many countries in the world. Those patients will develop complications like cirrhosis and HCC, which is one of the most common cancers in the world, especially in Egypt, and considered the third leading cause of death worldwide. The prognosis of HCC is still dismal due to the late diagnosis. miRNAs are small, short noncoding RNAs, which have roles in the diagnosis of HCC. In our study, we focus on biological aspects of miRNAs. We report that miR-501 is strongly expressed and observed in the process of HCC development. miR-501 regulation is important as an oncofetal relevant to the diagnosis of HCC. Method This study was conducted on 100 adult patients; 25 patients were positive for anti-HCV and 25 patients were negative for HCV and enrolled as a control group. Patients were categorized into three groups: fibrosis (n = 25), CHC (n = 25), and HCC (n = 25) related to HCV evident by CT abdomen. All patients and controls were subjected to full clinical assessment and laboratory investigation. Blood (8 mL) was withdrawn from subjects, and 3 mL was collected in EDTA tubes for processing total RNA extraction and miRNA. The remaining 5 mL was left for determination of biochemical parameters. miRN-501 expression levels were determined by RT-PCR. Results The data revealed a significant increase in levels of AST, ALT, ALP, and CBC in both HCC and CHC groups compared to controls. The results of miRNA expression showed that miR-501 was higher in the HCC group than non-HCC group at P1.1. Conclusion miR-501 can be used as a noninvasive biomarker for early diagnosis of HCC among patients with HCV on account of its affectability for HCC.

The role of the main ingredients of chocolate in the formation of its beneficial properties for the consumer

2021 ◽  
pp. 582-587
Author(s):  
I.V. Goloviznin ◽  
A.V. Ryzhakova
Keyword(s):  
Human Health ◽  
Complete Information ◽  
The Body ◽  
Specific Product ◽  
Regular Process ◽  
The World ◽  
The Impact ◽  
Confectionery Product

Chocolate is the most staple and consumed confectionery product in Russia and the world. The determination of the beneficial properties of such a product as chocolate is an important and regular process of food institutions in every country, since new lines of already well-known manufacturers and new manufacturers with an innovative assortment are added to the retail assortment. Today, it is very relevant and important to understand the impact of new products on human health. In this regard, in order to provide complete information on a specific product, it is necessary to know its composition, ingredients and their effect on the body separately and within the framework of a specific product. Along with its beneficial properties, chocolate can also affect health negatively. It is necessary to understand the mechanism of the effect of chocolate on human health when consumed and to assess the risks that may arise subsequently after its active consumption.

Brainstem death and organ donation

2010 ◽  
pp. 3161-3166
Author(s):  
M.J. Lindop
Keyword(s):  
United States ◽  
Cardiac Arrest ◽  
United States Of America ◽  
The United States ◽  
Clinical Criteria ◽  
The United Kingdom ◽  
Brainstem Death ◽  
Brainstem Function ◽  
Almost All ◽  
Irreversible Cessation

Brain death in the United States of America is defined as the ‘irreversible cessation of all functions of the entire brain, including the brainstem … that are clinically ascertainable’; in the United Kingdom the definition focuses on brainstem function. Half of those who fulfil the necessary clinical criteria will have a cardiac arrest despite intensive treatment within 24 h, and this happens to almost all within 72 h....

scholarly journals Les Allemagnes et la division Est-Ouest : Une ambivalence politique

2005 ◽  
Vol 16 (3) ◽  
pp. 547-559
Author(s):  
Paul Létourneau
Keyword(s):  
International Organizations ◽  
Special Functions ◽  
States Of Affairs ◽  
Concrete Case ◽  
Long Run ◽  
Official Policy ◽  
The World ◽  
Definition Of

This article is about the role of international bureaucracies in the determination of the general policies of international organizations. In this paper it is argued that in general international organizations' Secretariats generally do wield, considerable power over the definition of the institutions' strategies, i.e. those activities, priorities and projects which taken together make up the program of the institution for a given period. Indeed, the international bureaucrats exercise tremendous control over the content of the program. This is so because international organizations have special functions in the world System. They must see to it that, certain states of affairs prevail in the world over the long run. It is, therefore, no surprise that the programs' content be more or less shielded from conjonctural fluctuations. The article then proceeds to test these hypotheses on a concrete case: the analysis of the processus through which Unesco's program goes before becoming the official policy of the organization.

scholarly journals The Law on State Responsibility and the World Trade Organization

2021 ◽  
Vol 22 (5-6) ◽  
pp. 759-803
Author(s):  
Anna Ventouratou
Keyword(s):  
World Trade Organization ◽  
International Law ◽  
World Trade ◽  
Dispute Settlement ◽  
State Responsibility ◽  
Vienna Convention ◽  
The World ◽  
The Law

Abstract This paper examines the role of general international law in the World Trade Organization (WTO) regime, using the rules on state responsibility as a case study. It identifies and discusses instances in WTO case law where such rules were applied directly or were taken into consideration in interpreting relevant WTO provisions. The analysis demonstrates that direct application of general international law for the determination of indispensable matters not regulated by the WTO Agreements is part of the inherent powers of WTO adjudicative bodies. Moreover, under Article 3(2) Dispute Settlement Understanding and Article 31(3)(c) Vienna Convention on the Law of Treaties, WTO adjudicative bodies have an obligation to take into account general international law in interpreting relevant WTO provisions. The paper delineates the methodology for assessing the interaction between general international law and WTO law and highlights the importance of adhering to this methodology to provide clarity and legal certainty regarding the scope and content of WTO obligations.

scholarly journals Russia versus the West: Rosyjska kontra wobec świata Zachodu

2019 ◽  
Vol 5 (1) ◽  
pp. 8-17
Author(s):  
Mirosław Minkina
Keyword(s):  
Russian Federation ◽  
Research Effort ◽  
Dominant Role ◽  
Russian Society ◽  
The West ◽  
The World ◽  
The Russian Federation

Both Russian authorities and Russian society have a sense of harm associated with the position of Russia in the world. They do not agree with the dominant role of the West. To a large extent it is associated with a sense of Russian pride. The consequence of this situation is the growing confrontation between the Russian Federation and the West. Currently, the theatre of confrontation is i.a. the conflict in the east of Ukraine and the war in Syria. The intensification of military tension is also observed, the confirmation of which is the violation of the airspace of NATO members. The author of this article undertook research effort associated with the determination of the fields of confrontation between Russia and the West.

Modifying effects of TNF-α, IL-6 and VDR genes on the development risk and the course of COVID-19. Pilot study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Liliia Fishchuk ◽  
Zoia Rossokha ◽  
Valeriy Pokhylko ◽  
Yuliia Cherniavska ◽  
Svitlana Tsvirenko ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Study Group ◽  
Intensive Care Patients ◽  
Tnf Α ◽  
Pcr Rflp ◽  
The World ◽  
Laboratory Examinations ◽  
Development Risk

Abstract Objectives COVID-19 continues to range around the world and set morbidity and mortality antirecords. Determining the role of genetic factors in the development of COVID-19 may contribute to the understanding of the pathogenetic mechanisms that lead to the development of complications and fatalities in this disease. The aim of our study was to analyze the effect of TNF-α (rs1800629), IL-6 (rs1800795) and VDR (rs731236 and rs1544410) genes variants on the development risk and the course of COVID-19 in intensive care patients. Methods The study group included 31 patients with diagnosis “viral COVID-19 pneumonia”. All patients underwent standard daily repeated clinical, instrumental and laboratory examinations. Determination of IL-6, TNF-α, and VDR genes variants was performed using the PCR-RFLP method. Results It was found a significant increase in the rate of the CC genotype and C allele (38.7 vs. 12.0% and 0.6 vs. 0.4%, respectively) of the IL-6 gene in all patients of the study in comparison with population frequencies. There was a significantly higher rate of heterozygous genotypes TC and GA of the VDR gene in group of died patients. The rs1800629 variant of the TNF-α gene is associated with the need for respiratory support and its longer duration in patients with COVID-19. Conclusions The obtained results support a hypothesis about the influence of variants of IL-6, TNF-α and VDR genes on severity of COVID-19. However, in order to draw definite conclusions, further multifaceted research in this area are need.

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