HIV seroconversion in the third trimester of pregnancy: using raltegravir to prevent mother-to-child transmission

2013 ◽  
Vol 24 (3) ◽  
pp. 245-246 ◽  
Author(s):  
A Hegazi ◽  
P Hay
Keyword(s):  
Mother To Child Transmission ◽  
Child Transmission ◽  
Third Trimester ◽  
The Third ◽  
Hiv Seroconversion ◽  
Mother To Child

scholarly journals Efficacy and Safety of Lamivudine or Telbivudine in Preventing Mother-to-Child Transmission of Hepatitis B Virus: A Real-World Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Zhenhua Li ◽  
Xuefei Duan ◽  
Yuhong Hu ◽  
Mingfang Zhou ◽  
Min Liu ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Real World ◽  
Control Group ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Third Trimester ◽  
Safety And Efficacy ◽  
Large Sample ◽  
The Third ◽  
Mother To Child

Background. There are few large sample studies evaluating the safety and efficacy of lamivudine (LAM) or telbivudine (LdT) in preventing hepatitis B mother-to-child transmission (MTCT) in highly viremic mothers in the third trimester of pregnancy in real-world settings. The purpose of this study was to analyze a large sample size of HBV-infected mothers to better understand the safety and efficacy of LAM and LdT under the aforementioned criteria. Methods. During the period of November 2008 to November 2017, we retrospectively enrolled mothers with HBV DNA>1×106 IU/mL who received LAM or LdT during the third trimester of pregnancy and compared them to untreated mothers. All mothers were divided into the three following groups: the LAM group, the LdT group, and the control group. Results. A total of 2624 HBV-infected mothers were enrolled in the study, with 363 in the LAM group, 1283 in the LdT group, and 978 in the control group. The MTCT rates were significantly lower in the LAM or LdT group than that in the control group (0.4% or 0.3% versus 9.0%, P<0.001). Infants born to untreated mothers had a significantly higher risk of HBV infection (OR=28.6, 95% CI: 10.4–78.7, P<0.001). There were no significant differences in perinatal complications between the three groups (P>0.05). There were also no differences for gestational age or infants’ height, weight, Apgar scores, or birth defect rates. Postpartum discontinuation of antiviral therapy did not seem to increase the risk of postpartum alanine aminotransferase (ALT) flare. Conclusion. LAM or LdT treatment initiated in the third trimester for mothers with HBV DNA>1×106 IU/mL was equally safe and effective in preventing MTCT.

scholarly journals Antiretroviral Therapy with a Twice-Daily Regimen Containing 400 Milligrams of Indinavir and 100 Milligrams of Ritonavir in Human Immunodeficiency Virus Type 1-Infected Women during Pregnancy

2008 ◽  
Vol 52 (4) ◽  
pp. 1542-1544 ◽  
Author(s):  
Jade Ghosn ◽  
Ines De Montgolfier ◽  
Chantal Cornélie ◽  
Stéphanie Dominguez ◽  
Claire Pérot ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Daily Regimen ◽  
Child Transmission ◽  
Third Trimester ◽  
Safety And Efficacy ◽  
Hiv Rna ◽  
The Third ◽  
Immunodeficiency Virus ◽  
Mother To Child

ABSTRACT We evaluated the safety and efficacy of a twice daily regimen containing 400 mg of indinavir and 100 mg of ritonavir in 32 human immunodeficiency virus (HIV)-infected women during pregnancy. The median indinavir trough concentration was 208 ng/ml during the third trimester. At delivery, 26 of 28 women on indinavir-ritonavir had HIV RNA levels of <200 copies/ml. No infant was HIV infected. These data are encouraging for the use of this combination for prevention of mother-to-child transmission of HIV.

scholarly journals The outcome of exclusive breast feeding in infants born to HIV positive mothers on ART under SISU RAKSHA program, Bapuji child health institute, Davangere

2017 ◽  
Vol 4 (4) ◽  
pp. 1332
Author(s):  
Bhagyalakshmi R. T. ◽  
T. P. Manjunath ◽  
C. R. Banapurmath ◽  
Mruthunjaya S.
Keyword(s):  
Health Status ◽  
Child Health ◽  
Hiv Positive ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Health Institute ◽  
Hiv Positive Mothers ◽  
Hiv Seroconversion ◽  
Mother To Child

Background: Under SISU RAKSHA program (a joint initiative by SAATHII, not-for-profit organization and Bapuji child health institute, Davangere) the HIV positive pregnant mothers are enrolled, counseled and motivated during pregnancy, childbirth and breastfeeding to adhere to antiretroviral therapy (ART) and exclusive breastfeeding (EBF) to reduce mother to child transmission of HIV. Objective is to study the outcome of EBF on infants born to HIV positive mothers on ART under SISU RAKSHA program, with Outcome variables: HIV seroconversion, Growth status, Health status. Methods: 86 infant born to HIV positive mothers who completed 18 months follow up were included in the study. A prestuctured proforma was used to collect information about ART adherence, infant feeding practice, HIV seroconversion, growth and health status. Results: The HIV seroconversion of children on EBF among ART adherent mothers, 94.2 % (66/70) were non-reactive at 18th month follow up and 4.28% (3/70) were reactive. 92.8% (65/70) children growth were normal at 18th month follow up and 5.6% (4/70) were under weight and had recurrent infections. All these observations were statistically significant according to Fisher’s exact test. Conclusions: The rate of mother to child transmission of HIV and rate of other infections among children born to HIV positive mothers is reduced and growth is normal if the mother is adherent to EBF & ART. HIV positive mothers are regularly counseled and motivated to do so under the program. Therefore the SISU RAKSHA program is very effective program for prevention of mother to child transmission of HIV. 

scholarly journals HIV sero-conversion during late pregnancy – when to retest

2013 ◽  
Vol 14 (2) ◽  
pp. 90-92 ◽  
Author(s):  
Emma Kalk ◽  
Amy Slogrove ◽  
David P Speert ◽  
Julie A Bettinger ◽  
Mark F Cotton ◽  
...  
Keyword(s):  
South African ◽  
Vertical Transmission ◽  
Late Pregnancy ◽  
Hiv Infections ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
The South ◽  
Hiv Seroconversion ◽  
National Prevention ◽  
Mother To Child

The South African National Prevention of Mother-to-Child Transmission of HIV programme has resulted in significant reductions in vertical transmission, but new infant HIV infections continue to occur. We present two cases of HIV seroconversion during late pregnancy, demonstrating the limitations of the current programme. These could be mitigated by expanding the programme to include maternal testing at delivery and at immunisation clinic visits as we pursue the elimination of mother-to-child transmission.

scholarly journals The Contribution of Maternal HIV Seroconversion During Late Pregnancy and Breastfeeding to Mother-to-Child Transmission of HIV

2012 ◽  
Vol 59 (4) ◽  
pp. 417-425 ◽  
Author(s):  
Leigh F. Johnson ◽  
Kathryn Stinson ◽  
Marie-Louise Newell ◽  
Ruth M. Bland ◽  
Harry Moultrie ◽  
...  
Keyword(s):  
Late Pregnancy ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Hiv Seroconversion ◽  
Maternal Hiv ◽  
Mother To Child

Mother-to-child transmission of HIV: developing integration of healthcare programmes with clinical, social and basic research studies

2003 ◽  
Vol 92 (11) ◽  
pp. 1343-1348
Author(s):  
Menu E ◽  
Scarlatti G ◽  
Barr&#x000E9;-Sinoussi F ◽  
Gray G ◽  
Bollinger B ◽  
...  
Keyword(s):  
Basic Research ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Research Studies
Sign in / Sign up

Export Citation Format

Share Document