Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment

2012 ◽  
Vol 237 (11) ◽  
pp. 1289-1297 ◽  
Author(s):  
Isao Tsuboi ◽  
Tomonori Harada ◽  
Yoko Hirabayashi ◽  
Jun Kanno ◽  
Tohru Inoue ◽  
...  
Keyword(s):  
Mast Cell ◽  
Stromal Cell ◽  
Cell Regeneration ◽  
Age Related ◽  
Senescence Accelerated Mice

Inflammatory biomarker, neopterin, enlarges splenic mast-cell-progenitor pool: Prominent impairment of responses in age-related stromal cell-impairment mouse SCI/SAM

2006 ◽  
Vol 6 (12) ◽  
pp. 1847-1858 ◽  
Author(s):  
Toshitaka Fukumoto ◽  
Isao Tsuboi ◽  
Tomonori Harada ◽  
Masaki Hiramoto ◽  
Akihiro Minami ◽  
...  
Keyword(s):  
Mast Cell ◽  
Stromal Cell ◽  
Inflammatory Biomarker ◽  
Age Related ◽  
Mast Cell Progenitor

Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: effects of a single dose of 5-fluorouracil

2008 ◽  
Vol 28 (6) ◽  
pp. 797-805 ◽  
Author(s):  
Isao Tsuboi ◽  
Yoko Hirabayashi ◽  
Tomonori Harada ◽  
Morimichi Koshinaga ◽  
Tatsuro Kawamata ◽  
...  
Keyword(s):  
Single Dose ◽  
B Cell ◽  
Stromal Cell ◽  
Cell Regeneration ◽  
Hematopoietic Microenvironment ◽  
Age Related ◽  
Samp1 Mouse

scholarly journals Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment

Blood ◽  
2019 ◽  
Vol 133 (5) ◽  
pp. 446-456 ◽  
Author(s):  
Amina M. Abdul-Aziz ◽  
Yu Sun ◽  
Charlotte Hellmich ◽  
Christopher R. Marlein ◽  
Jayna Mistry ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Stromal Cells ◽  
Myeloid Leukemia ◽  
Stromal Cell ◽  
Cell Senescence ◽  
Senescent Phenotype ◽  
Age Related ◽  
Acute Myeloid

Abstract Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest of cell proliferation and the secretion of a set of proinflammatory cytokines, chemokines, and growth factors, collectively known as the senescence-associated secretory phenotype (SASP). Here, we report that AML blasts induce a senescent phenotype in the stromal cells within the BM microenvironment and that the BM stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feed back to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a+ senescent BM stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML-induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model, we show that by targeting NOX2 we reduced BM stromal cell senescence and consequently reduced AML proliferation. Together, these data identify leukemia-generated NOX2-derived superoxide as a driver of protumoral p16INK4a-dependent senescence in BM stromal cells. Our findings reveal the importance of a senescent microenvironment for the pathophysiology of leukemia. These data now open the door to investigate drugs that specifically target the “benign” senescent cells that surround and support AML.

Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice

2003 ◽  
Vol 2 (2) ◽  
pp. 211-243 ◽  
Author(s):  
Thomas V Getchell ◽  
Xuejun Peng ◽  
Arnold J Stromberg ◽  
Kuey-Chu Chen ◽  
C Paul Green ◽  
...  
Keyword(s):  
Gene Expression ◽  
Age Related ◽  
Senescence Accelerated Mice

Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice

1990 ◽  
Vol 56 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Hiroko Izumi-Hisha ◽  
Yoshitake Ito ◽  
Kenkichi Sugimoto ◽  
Hidehiko Oshima ◽  
Kazuhiro J. Mori
Keyword(s):  
Stem Cells ◽  
Hemopoietic Stem Cells ◽  
Age Related ◽  
Senescence Accelerated Mice

1404 Age-related morphological alterations in the cerebellar cortical layer of cats and senescence-accelerated mice

1997 ◽  
Vol 28 ◽  
pp. S179
Author(s):  
Sachio Nagasaki ◽  
Kazuko Watanabe ◽  
Tetsu Yamamoto ◽  
Nobuyuki Karasawa ◽  
Ikuko Nagatsu ◽  
...  
Keyword(s):  
Cortical Layer ◽  
Morphological Alterations ◽  
Age Related ◽  
Senescence Accelerated Mice

Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice

1995 ◽  
Vol 90 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Katsunori Ohnishi ◽  
Hidekazu Tomimoto ◽  
Ichiro Akiguchi ◽  
Naoyuki Seriu ◽  
Toshio Kawamata ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Basal Forebrain ◽  
Nerve Growth ◽  
Age Related ◽  
Senescence Accelerated Mice
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