Low expression of prolyl hydroxylase 2 is associated with tumor grade and poor prognosis in patients with colorectal cancer

2012 ◽  
Vol 237 (7) ◽  
pp. 860-866 ◽  
Author(s):  
Ganfeng Xie ◽  
Lei Zheng ◽  
Juanjuan Ou ◽  
Haihui Huang ◽  
Jinxia He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Tumor Grade ◽  
Prolyl Hydroxylase ◽  
Low Expression

Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer: The question is still open

Cancer ◽  
2015 ◽  
Vol 121 (21) ◽  
pp. 3922-3923 ◽  
Author(s):  
Soodabeh ShahidSales ◽  
Majid Ghayour Mobarhan ◽  
Faezeh Ghasemi ◽  
Sharareh Gholamin ◽  
Amir Avan
Keyword(s):  
Colorectal Cancer ◽  
Chloride Channel ◽  
Poor Prognosis ◽  
Low Expression

scholarly journals FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Weixing Dai ◽  
Xianke Meng ◽  
Shaobo Mo ◽  
Wenqiang Xiang ◽  
Ye Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Poor Prognosis ◽  
Aerobic Glycolysis ◽  
Lactate Production ◽  
Glucose Consumption ◽  
Underlying Mechanism ◽  
Low Expression

Abstract Background Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying mechanism remains unclear. Materials and methods The effects of FOXE1 on the growth of colon cancer cells and the expression of glycolytic enzymes were investigated in vitro and in vivo. Molecular biological experiments were used to reveal the underlying mechanisms of altered aerobic glycolysis. CRC tissue specimens were used to determine the clinical association of ectopic metabolism caused by dysregulated FOXE1. Results FOXE1 is highly expressed in normal colon tissues compared with cancer tissues and low expression of FOXE1 is significantly associated with poor prognosis of CRC patients. Silencing FOXE1 in CRC cell lines dramatically enhanced cell proliferation and colony formation and promoted glucose consumption and lactate production, while enforced expression of FOXE1 manifested the opposite effects. Mechanistically, FOXE1 bound directly to the promoter region of HK2 and negatively regulated its transcription. Furthermore, the expression of FOXE1 in CRC tissues was negatively correlated with that of HK2. Conclusion FOXE1 functions as a critical tumor suppressor in regulating tumor growth and glycolysis via suppressing HK2 in CRC.

scholarly journals Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0159954 ◽  
Author(s):  
Haiyan Yan ◽  
Kaishun Hu ◽  
Wenjing Wu ◽  
Yu Li ◽  
Huan Tian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Phosphorylation ◽  
Poor Prognosis ◽  
Dual Specificity ◽  
Low Expression

scholarly journals Low expression of novel lncRNA RP11-462C24.1 suggests a biomarker of poor prognosis in colorectal cancer

2014 ◽  
Vol 31 (7) ◽  
Author(s):  
Debing Shi ◽  
Hongtu Zheng ◽  
Changhua Zhuo ◽  
Junjie Peng ◽  
Dawei Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Low Expression

scholarly journals Low expression of PKCα and high expression of KRAS predict poor prognosis in patients with colorectal cancer

2016 ◽  
Vol 12 (3) ◽  
pp. 1655-1660 ◽  
Author(s):  
Suxian Chen ◽  
Yadi Wang ◽  
Yun Zhang ◽  
Yizeng Wan
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
High Expression ◽  
Low Expression

scholarly journals Low expression of LOC285194 is associated with poor prognosis in colorectal cancer

2013 ◽  
Vol 11 (1) ◽  
pp. 122 ◽  
Author(s):  
Peng Qi ◽  
Mi-die Xu ◽  
Shu-juan Ni ◽  
Dan Huang ◽  
Ping Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Low Expression

scholarly journals Low expression levels of micro RNA ‐124‐5p correlated with poor prognosis in colorectal cancer via targeting of SMC 4

2014 ◽  
Vol 3 (6) ◽  
pp. 1544-1552 ◽  
Author(s):  
Takafumi Jinushi ◽  
Yoshihiko Shibayama ◽  
Ichiro Kinoshita ◽  
Satoshi Oizumi ◽  
Masahisa Jinushi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Micro Rna ◽  
Expression Levels ◽  
Low Expression
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