scholarly journals Low expression of PKCα and high expression of KRAS predict poor prognosis in patients with colorectal cancer

2016 ◽  
Vol 12 (3) ◽  
pp. 1655-1660 ◽  
Author(s):  
Suxian Chen ◽  
Yadi Wang ◽  
Yun Zhang ◽  
Yizeng Wan
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
High Expression ◽  
Low Expression

High Expression of LTBP2 Contributes to Poor Prognosis in Patients with Colorectal Cancer

2018 ◽  
Author(s):  
Ying Huang ◽  
Guihua Wang ◽  
Chunmei Zhao ◽  
Rong Geng ◽  
Shu Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
High Expression

Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer: The question is still open

Cancer ◽  
2015 ◽  
Vol 121 (21) ◽  
pp. 3922-3923 ◽  
Author(s):  
Soodabeh ShahidSales ◽  
Majid Ghayour Mobarhan ◽  
Faezeh Ghasemi ◽  
Sharareh Gholamin ◽  
Amir Avan
Keyword(s):  
Colorectal Cancer ◽  
Chloride Channel ◽  
Poor Prognosis ◽  
Low Expression

scholarly journals FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Weixing Dai ◽  
Xianke Meng ◽  
Shaobo Mo ◽  
Wenqiang Xiang ◽  
Ye Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Poor Prognosis ◽  
Aerobic Glycolysis ◽  
Lactate Production ◽  
Glucose Consumption ◽  
Underlying Mechanism ◽  
Low Expression

Abstract Background Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying mechanism remains unclear. Materials and methods The effects of FOXE1 on the growth of colon cancer cells and the expression of glycolytic enzymes were investigated in vitro and in vivo. Molecular biological experiments were used to reveal the underlying mechanisms of altered aerobic glycolysis. CRC tissue specimens were used to determine the clinical association of ectopic metabolism caused by dysregulated FOXE1. Results FOXE1 is highly expressed in normal colon tissues compared with cancer tissues and low expression of FOXE1 is significantly associated with poor prognosis of CRC patients. Silencing FOXE1 in CRC cell lines dramatically enhanced cell proliferation and colony formation and promoted glucose consumption and lactate production, while enforced expression of FOXE1 manifested the opposite effects. Mechanistically, FOXE1 bound directly to the promoter region of HK2 and negatively regulated its transcription. Furthermore, the expression of FOXE1 in CRC tissues was negatively correlated with that of HK2. Conclusion FOXE1 functions as a critical tumor suppressor in regulating tumor growth and glycolysis via suppressing HK2 in CRC.

scholarly journals Prognostic roles of microRNA 143 and microRNA 145 in colorectal cancer: A meta-analysis

2019 ◽  
Vol 34 (1) ◽  
pp. 6-14 ◽  
Author(s):  
Chenyao Li ◽  
Guoqiang Yan ◽  
Libin Yin ◽  
Tao Liu ◽  
Chao Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Hazard Ratio ◽  
High Expression ◽  
Cochrane Library ◽  
Event Free Survival ◽  
Free Survival ◽  
High Event ◽  
Low Expression

Background: A systematic analysis was conducted to clarify the relationship between miR-143/145 and the prognosis of colorectal cancer. Materials and methods: We searched four databases: PubMed, EMBASE, Web of Science, and the Cochrane Library. We extracted and estimated the hazard ratios for survival outcomes, which compared low and high expression levels of miR-143/145 in colorectal cancer patients in the available studies. Each individual hazard ratio was used to calculate the pooled hazard ratio. Results: A total of 17 articles including 5128 patients were ultimately included. The results showed that there was no significant difference between low expression and high expression of miR-143 in the overall survival of colon cancer patients. However, low expression of miR-143 was significantly associated with high event-free survival (hazard ratio (HR) 0.6; 95% confidence interval (CI) 0.40, 0.88). Low expression of miR-145 was associated with poor prognosis of patients (HR 1.92; 95% CI 1.45, 2.54); those with low expression of miR-145 were at 1.92-fold higher risk for short-term overall survival than those with high expression of miR-145. MiR-145 was an unfavorable factor for the prognosis of colorectal cancer. There were no significant differences between low expression of miR-145 and high expression of miR-143 in event-free survival. Conclusion: miR-143 and miR-145 have promising prognostic value for colorectal cancer. Low expression of miR-143 can predict high event-free survival, and low expression of miR-145 can predict poor overall survival.

scholarly journals High expression of ZEB1 correlates with liver metastasis and poor prognosis in colorectal cancer

2012 ◽  
Vol 5 (2) ◽  
pp. 564-568 ◽  
Author(s):  
GUANG-JUN ZHANG ◽  
TONG ZHOU ◽  
HONG-PENG TIAN ◽  
ZUO-LIANG LIU ◽  
SHU-SEN XIA
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Poor Prognosis ◽  
High Expression

Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer

2010 ◽  
Vol 46 (4) ◽  
pp. 826-835 ◽  
Author(s):  
Cecilia Magnusson ◽  
Maryna Mezhybovska ◽  
Ester Lörinc ◽  
Eva Fernebro ◽  
Mef Nilbert ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Good Prognosis ◽  
High Expression ◽  
Low Expression

scholarly journals Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

Hematology ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 448-455 ◽  
Author(s):  
Ming Ma ◽  
Riyang Zhao ◽  
Xingxiao Yang ◽  
Lianmei Zhao ◽  
Lihua Liu ◽  
...  
Keyword(s):  
Burkitt Lymphoma ◽  
Poor Prognosis ◽  
High Expression ◽  
Low Expression
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