Insulin resistance induces medial artery calcification in fructose-fed rats

2012 ◽  
Vol 237 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Ye-bo Zhou ◽  
Jing Zhang ◽  
Yan Cai ◽  
Xu Teng ◽  
Xiao-hui Duan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Medial Artery Calcification ◽  
Medial Artery

Medial Artery Calcification

1996 ◽  
Vol 16 (8) ◽  
pp. 978-983 ◽  
Author(s):  
Seppo Lehto ◽  
Leo Niskanen ◽  
Matti Suhonen ◽  
Tapani Rönnemaa ◽  
Markku Laakso
Keyword(s):  
Medial Artery Calcification ◽  
Medial Artery

scholarly journals Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification

2015 ◽  
Vol 30 (5) ◽  
pp. 824-836 ◽  
Author(s):  
Campbell R Sheen ◽  
Pia Kuss ◽  
Sonoko Narisawa ◽  
Manisha C Yadav ◽  
Jessica Nigro ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Pathophysiological Role ◽  
Medial Artery Calcification ◽  
Medial Artery

scholarly journals Medial artery calcification increases neointimal hyperplasia after balloon injury

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Andre P. Marshall ◽  
Weifeng Luo ◽  
Xue-lin Wang ◽  
Tonghui Lin ◽  
Yujun Cai ◽  
...  
Keyword(s):  
Neointimal Hyperplasia ◽  
Balloon Injury ◽  
Medial Artery Calcification ◽  
Medial Artery

Abstract 242: MMP-3 Promotes SMC Transformation During Medial Artery Calcification

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Tonghui Lin ◽  
Xue-lin Wang ◽  
Sara Zettervall ◽  
Yujun Cai ◽  
Alyssa Flores ◽  
...  
Keyword(s):  
Vitamin D ◽  
Marker Gene ◽  
Arterial Calcification ◽  
Marker Genes ◽  
Local Effects ◽  
Phenotypic Marker ◽  
Vascular Smcs ◽  
Cardiovascular Morbidity And Mortality ◽  
Medial Artery Calcification ◽  
Medial Artery

Objective: Medial artery calcification is associated with increased cardiovascular morbidity and mortality. It occurs with diabetes and chronic kidney disease. We have previously demonstrated that the matrix metallopeptidase 3 (MMP-3) is strongly induced in arterial calcification. We also showed that MMP-3 inhibition decreases calcium accumulation in vascular SMCs and that MMP-3 deficient mice develop less medial calcification than wildtype controls. In this series of continuing experiments, we evaluate the effects of MMP-3 on SMCs phenotypic transformation in vitro and in vivo. Methods and Results: Confluent rat aortic smooth muscle cells (RASMCs) cultured in calcification medium containing elevated calcium and phosphate levels for 7 days showed increased MMP-3 activity, decreased expression of the SMC markers SM-actin and SM-MHC, and increased expression of the bone markers alkaline phosphatase (ALP) and osterix (Osx). Cells were next exposed a selective MMP-3 inhibitor 2(EMD Millipore). In the presence of inhibitor, MMP-3 activity (MMP-3 activity assay kit, Abcam) was significantly decreased. Additionally, SMC osteogenic transformation was prevented as demonstrated by maintenance of SM22α and SM-MHC expression with reduction of ALP and Osx expression. In confirmatory experiments, MMP-3 reduction with siRNA inhibited the calcification of SMC that were exposed to calcification medium. We next evaluated phenotypic marker expression in MMP-3 knockout and wild-type mice injected with vitamin D 3 , a model of medial artery calcification. At 7 days after injection, expression of the SMC marker gene SM-MHC was significantly greater in MMP-3 KO mice than controls, while bone cell marker genes (Runx2, ALP, Osx) were decreased as measured by qPCR. Deletion of MMP-3 thus inhibited the osteogenic transformation of medial SMCs in vitamin D 3 -treated mice suggesting that it may control calcification via local effects within the arterial wall. Conclusion: Together these findings suggest that MMP-3 promotes medial artery calcification through local effects on the phenotypic state of vascular SMCs, and further, that it may serve as a therapeutic target to reduce calcification and improve outcomes in our PAD patient population.

scholarly journals FP642OSTEOPROTEGERIN AS A VASCULAR RISK FACTOR: FOR RADIAL MEDIAL ARTERY CALCIFICATION AND DEVELOPMENT OF ATHEROSLEROSIS IN CKD PATIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii288-iii288
Author(s):  
Marcin Krzanowski ◽  
Katarzyna Krzanowska ◽  
Mariusz Gajda ◽  
Paulina Dumnicka ◽  
Danuta Fedak ◽  
...  
Keyword(s):  
Risk Factor ◽  
Vascular Risk Factor ◽  
Vascular Risk ◽  
Medial Artery Calcification ◽  
Medial Artery

scholarly journals Hdac9 inhibits medial artery calcification through down-regulation of Osterix

2020 ◽  
Vol 132 ◽  
pp. 106775
Author(s):  
Pengcheng He ◽  
Hongjiao Yu ◽  
Lei Jiang ◽  
Ziying Chen ◽  
Siying Wang ◽  
...  
Keyword(s):  
Down Regulation ◽  
Medial Artery Calcification ◽  
Medial Artery

scholarly journals Reversibility of Calcitriol-Induced Medial Artery Calcification in Rats With Intact Renal Function

2005 ◽  
Vol 21 (3) ◽  
pp. 484-490 ◽  
Author(s):  
Alicia Bas ◽  
Ignacio Lopez ◽  
Jose Perez ◽  
Mariano Rodriguez ◽  
Escolastico Aguilera-Tejero
Keyword(s):  
Renal Function ◽  
Medial Artery Calcification ◽  
Medial Artery

Medial Artery Calcification as an Indicator of Diabetic Peripheral Vascular Disease

2008 ◽  
Vol 29 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Christopher David Smith ◽  
Jonathan Gavin Bilmen ◽  
Shehzad Iqbal ◽  
Sharon Robey ◽  
Melwyn Pereira
Keyword(s):  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Peripheral Vascular ◽  
Medial Artery Calcification ◽  
Medial Artery
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