scholarly journals Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification

2017 ◽  
Vol 66 (2) ◽  
pp. 586-593 ◽  
Author(s):  
Tonghui Lin ◽  
Xue-Lin Wang ◽  
Sara L. Zettervall ◽  
Yujun Cai ◽  
Raul J. Guzman
Keyword(s):  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Protein Inhibitor ◽  
Morphogenetic Protein ◽  
Medial Artery Calcification ◽  
Medial Artery

scholarly journals Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Bone ◽  
2020 ◽  
Vol 138 ◽  
pp. 115472 ◽  
Author(s):  
Gonzalo Sanchez-Duffhues ◽  
Eleanor Williams ◽  
Marie-Jose Goumans ◽  
Carl-Henrik Heldin ◽  
Peter ten Dijke
Keyword(s):  
Structure Function ◽  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Kinase Inhibitors ◽  
Morphogenetic Protein ◽  
Protein Receptors ◽  
Bone Morphogenetic Protein Receptors

scholarly journals Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jiabing Fan ◽  
Joan Pi-Anfruns ◽  
Mian Guo ◽  
Dan C. S. Im ◽  
Zhong-Kai Cui ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein

scholarly journals Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth

2015 ◽  
Vol 368 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Laura D. Hover ◽  
Christian D. Young ◽  
Neil E. Bhola ◽  
Andrew J. Wilson ◽  
Dineo Khabele ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Bone Morphogenetic Protein ◽  
Cancer Cell ◽  
Small Molecule ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Growth ◽  
Bone Morphogenetic Protein Pathway ◽  
Morphogenetic Protein ◽  
Molecule Inhibitor

scholarly journals A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels

2018 ◽  
Vol 51 (4) ◽  
pp. 1702229 ◽  
Author(s):  
Yanjiang Xing ◽  
Shuang Zhao ◽  
Qingxia Wei ◽  
Shiqiang Gong ◽  
Xin Zhao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Stem Cell ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Embryonic Stem ◽  
Morphogenetic Protein ◽  
Small Molecule Compound ◽  
Pulmonary Arterial

Genetic defects in bone morphogenetic protein type II receptor (BMPRII) signalling and inflammation contribute to the pathogenesis of pulmonary arterial hypertension (PAH). The receptor is activated by bone morphogenetic protein (BMP) ligands, which also enhance BMPR2 transcription. A small-molecule BMP upregulator with selectivity on vascular endothelium would be a desirable therapeutic intervention for PAH.We assayed compounds identified in the screening of BMP2 upregulators for their ability to increase the expression of inhibitor of DNA binding 1 (Id1), using a dual reporter driven specifically in human embryonic stem cell-derived endothelial cells. These assays identified a novel piperidine, BMP upregulator 1 (BUR1), that increased endothelial Id1 expression with a half-maximal effective concentration of 0.098 μmol·L−1. Microarray analyses and immunoblotting showed that BUR1 induced BMP2 and prostaglandin-endoperoxide synthase 2 (PTGS2) expression. BUR1 effectively rescued deficient angiogenesis in autologous BMPR2+/R899X endothelial cells generated by CRISPR/Cas9 and patient cells.BUR1 prevented and reversed PAH in monocrotaline rats, and restored BMPRII downstream signalling and modulated the arachidonic acid pathway in the pulmonary arterial endothelium in the Sugen 5416/hypoxia PAH mouse model.In conclusion, using stem cell technology we have provided a novel small-molecule compound which regulates BMP2 and PTGS2 levels that might be useful for the treatment of PAH.

scholarly journals Enhanced Mandibular Bone Repair by Combined Treatment of Bone Morphogenetic Protein 2 and Small-Molecule Phenamil

2017 ◽  
Vol 23 (5-6) ◽  
pp. 195-207 ◽  
Author(s):  
Jiabing Fan ◽  
Mian Guo ◽  
Choong Sung Im ◽  
Joan Pi-Anfruns ◽  
Zhong-Kai Cui ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Small Molecule ◽  
Bone Repair ◽  
Combined Treatment ◽  
Bone Morphogenetic Protein 2 ◽  
Mandibular Bone ◽  
Morphogenetic Protein

Expression, signalling and potential in vivo functions of Bone Morphogenetic Protein (BMP)-9 in the liver

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
K Breitkopf ◽  
A Müller ◽  
L Ciuclan ◽  
E Wiercinska ◽  
P ten Dijke ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein
Sign in / Sign up

Export Citation Format

Share Document