scholarly journals Effects of Nonpeptide and Selective V1 and V2 Antagonists on Blood Pressure Short-Term Variability in Spontaneously Hypertensive Rats

2004 ◽  
Vol 95 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Nina Japundzic-Zigon ◽  
Sanja Milutinovic ◽  
Aleksandar Jovanovic
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Short Term ◽  
Spontaneously Hypertensive ◽  
Short Term Variability

scholarly journals The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

2015 ◽  
Vol 6 (11) ◽  
pp. 3479-3489 ◽  
Author(s):  
Mar Quiñones ◽  
Maria Margalef ◽  
Anna Arola-Arnal ◽  
Begoña Muguerza ◽  
Marta Miguel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Levels ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Pressure Effect ◽  
Hypertensive Rats ◽  
Short Term ◽  
Spontaneously Hypertensive ◽  
Blood Pressure Effect

We studied the short-term antihypertensive effect of flavan-3-ols (−)-epicatechin, (+)-catechin and (−)-catechin, in spontaneously hypertensive rats (SHR).

Effect of nebivolol on beat-to-beat and short-term blood pressure variability in spontaneously hypertensive rats

2012 ◽  
Vol 385 (8) ◽  
pp. 833-843 ◽  
Author(s):  
Facundo Martín Bertera ◽  
Julieta Sofía Del Mauro ◽  
Ariel Héctor Polizio ◽  
Diego Chiappetta ◽  
Carlos Alberto Taira ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Short Term ◽  
Spontaneously Hypertensive

scholarly journals Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Bo Li ◽  
Zheng-Biao Yang ◽  
Shan-Shan Lei ◽  
Jie Su ◽  
Min-Xia Pang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Rats ◽  
Short Term ◽  
Spontaneously Hypertensive ◽  
Radix Paeoniae Alba

Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.

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