scholarly journals Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats

Aging Cell ◽  
2020 ◽  
Vol 19 (10) ◽  
Author(s):  
Hilaree N. Frazier ◽  
Katie L. Anderson ◽  
Adam O. Ghoweri ◽  
Ruei-Lung Lin ◽  
Tara R. Hawkinson ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Memory Recall ◽  
Receptor Signaling ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Insulin Receptor Signaling

scholarly journals Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet  -cell

Diabetes ◽  
2006 ◽  
Vol 55 (6) ◽  
pp. 1581-1591 ◽  
Author(s):  
S. C. Martinez ◽  
C. Cras-Meneur ◽  
E. Bernal-Mizrachi ◽  
M. A. Permutt
Keyword(s):  
Insulin Receptor ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Receptor Signaling ◽  
Pancreatic Islet Cell ◽  
Insulin Receptor Signaling

Abstract PO-056: Insulin receptor signaling in pancreatic acinar cells contributes to pancreatic cancer development

2021 ◽  
Author(s):  
Anni M. Y. Zhang ◽  
Jenny C. C. Yang ◽  
Twan J. J. de Winter ◽  
David F. Schaeffer ◽  
Janel L. Kopp ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Insulin Receptor ◽  
Acinar Cells ◽  
Cancer Development ◽  
Pancreatic Acinar Cells ◽  
Receptor Signaling ◽  
Insulin Receptor Signaling

scholarly journals Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling

2019 ◽  
Vol 316 (4) ◽  
pp. E660-E673 ◽  
Author(s):  
Katrine D. Galsgaard ◽  
Marie Winther-Sørensen ◽  
Jens Pedersen ◽  
Sasha A. S. Kjeldsen ◽  
Mette M. Rosenkilde ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Insulin Receptor ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Receptor Signaling ◽  
Cell Secretion ◽  
Glucagon Receptor ◽  
Insulin Receptor Signaling ◽  
Glucagon And Insulin

Glucagon and insulin are important regulators of blood glucose. The importance of insulin receptor signaling for alpha-cell secretion and of glucagon receptor signaling for beta-cell secretion is widely discussed and of clinical interest. Amino acids are powerful secretagogues for both hormones, and glucagon controls amino acid metabolism through ureagenesis. The role of insulin in amino acid metabolism is less clear. Female C57BL/6JRj mice received an insulin receptor antagonist (IRA) (S961; 30 nmol/kg), a glucagon receptor antagonist (GRA) (25-2648; 100 mg/kg), or both GRA and IRA (GRA + IRA) 3 h before intravenous administration of similar volumes of saline, glucose (0.5 g/kg), or amino acids (1 µmol/g) while anesthetized with isoflurane. IRA caused basal hyperglycemia, hyperinsulinemia, and hyperglucagonemia. Unexpectedly, IRA lowered basal plasma concentrations of amino acids, whereas GRA increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations. After administration of GRA + IRA, insulin secretion was significantly reduced compared with IRA administration alone. Blood glucose responses to a glucose and amino acid challenge were similar after vehicle and GRA + IRA administration but greater after IRA and lower after GRA. Anesthesia may have influenced the results, which otherwise strongly suggest that both hormones are essential for the maintenance of glucose homeostasis and that the secretion of both is regulated by powerful negative feedback mechanisms. In addition, insulin limits glucagon secretion, while endogenous glucagon stimulates insulin secretion, revealed during lack of insulin autocrine feedback. Finally, glucagon receptor signaling seems to be of greater importance for amino acid metabolism than insulin receptor signaling.

scholarly journals Insulin Receptor Signaling in the GnRH Neuron Plays a Role in the Abnormal GnRH Pulsatility of Obese Female Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119995 ◽  
Author(s):  
Sara A. DiVall ◽  
Danny Herrera ◽  
Bonnie Sklar ◽  
Sheng Wu ◽  
Fredric Wondisford ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Signaling ◽  
Gnrh Neuron ◽  
Female Mice ◽  
Obese Female ◽  
Insulin Receptor Signaling
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