scholarly journals Protective Effect of Ebselen, a Seleno-Organic Compound, Against the Progression of Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats

2002 ◽  
Vol 90 (4) ◽  
pp. 295-303 ◽  
Author(s):  
Yoshiji Ohta ◽  
Takashi Kobayashi ◽  
Kazuo Inui ◽  
Junji Yoshino ◽  
Saburo Nakazawa
Keyword(s):  
Mast Cell ◽  
Organic Compound ◽  
Protective Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Protective Effect of Teprenone Against Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats

2003 ◽  
Vol 93 (3) ◽  
pp. 337-346 ◽  
Author(s):  
Yoshiji Ohta ◽  
Takashi Kobayashi ◽  
Kazuo Inui ◽  
Junji Yoshino ◽  
Saburo Nakazawa
Keyword(s):  
Mast Cell ◽  
Protective Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Resistance of mast cell-deficient W/Wv mice to H.pylori -associated gastric mucosal lesions

2001 ◽  
Vol 120 (5) ◽  
pp. A650-A650
Author(s):  
H SUZUKI ◽  
M MIYAZAWA ◽  
A KAI ◽  
S MIURA ◽  
H NAGATA ◽  
...  
Keyword(s):  
Mast Cell ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective Effect of Taurine against Ammonia-Induced Gastric Mucosal Lesions in Rats

1989 ◽  
Vol 51 (4) ◽  
pp. 569-571
Author(s):  
Motonobu MURAKAMI ◽  
Jung Keun YOO ◽  
Sanae TERAMURA ◽  
Ko YAMAMOTO ◽  
Hiroshi SAITA ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective effect of paracetamol on stress-induced gastric mucosal lesions in rats.

1994 ◽  
Vol 64 ◽  
pp. 87
Author(s):  
Hideshi Omura ◽  
Kazuhisa Maeda ◽  
Masahiko Ishimura ◽  
Yoshinori Kamisaki ◽  
Tadao Itoh
Keyword(s):  
Protective Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective Effect of Repeatedly Preadministered Brazilian Propolis Ethanol Extract against Stress-Induced Gastric Mucosal Lesions in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Tadashi Nakamura ◽  
Yoshiji Ohta ◽  
Kumiko Ikeno ◽  
Koji Ohashi ◽  
Takeyuki Ikeno
Keyword(s):  
Protective Effect ◽  
Restraint Stress ◽  
Wistar Rats ◽  
Water Immersion ◽  
Ethanol Extract ◽  
Neutrophil Infiltration ◽  
Gastric Mucosal Lesions ◽  
Male Wistar Rats ◽  
Mucosal Lesions ◽  
Brazilian Propolis

The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single preadministration (50 mg/kg). The repeated BPEE preadministration attenuated WIRS-induced gastric mucosal lesions and gastric mucosal oxidative stress more largely than the single BPEE preadministration. In addition, the repeated BPEE preadministration attenuated neutrophil infiltration in the gastric mucosa of rats exposed to WIRS. The protective effect of the repeated preadministration of BPEE against WIRS-induced gastric mucosal lesions was similar to that of a single preadministration of vitamin E (250 mg/kg) in terms of the extent and manner of protection. From these findings, it is concluded that BPEE preadministered in a repeated manner protects against gastric mucosal lesions in rats exposed to WIRS more effectively than BPEE preadministered in a single manner possibly through its antioxidant and anti-inflammatory actions.

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