Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats

1994 ◽  
Vol 41 (1-2) ◽  
pp. 21-24 ◽  
Author(s):  
Y. Tabuchi ◽  
K. Kawarabayashi ◽  
K. Furuhama
Keyword(s):  
Mast Cell ◽  
Inhibitory Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Resistance of mast cell-deficient W/Wv mice to H.pylori -associated gastric mucosal lesions

2001 ◽  
Vol 120 (5) ◽  
pp. A650-A650
Author(s):  
H SUZUKI ◽  
M MIYAZAWA ◽  
A KAI ◽  
S MIURA ◽  
H NAGATA ◽  
...  
Keyword(s):  
Mast Cell ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Protective Effect of Teprenone Against Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats

2003 ◽  
Vol 93 (3) ◽  
pp. 337-346 ◽  
Author(s):  
Yoshiji Ohta ◽  
Takashi Kobayashi ◽  
Kazuo Inui ◽  
Junji Yoshino ◽  
Saburo Nakazawa
Keyword(s):  
Mast Cell ◽  
Protective Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Plaunotol Prevents the Progression of Acute Gastric Mucosal Lesions Induced by Compound 48/80, a Mast Cell Degranulator, in Rats

Pharmacology ◽  
2005 ◽  
Vol 74 (4) ◽  
pp. 182-192 ◽  
Author(s):  
Yoshiji Ohta ◽  
Yoshio Kamiya ◽  
Yoichiro Imai ◽  
Tomiyasu Arisawa ◽  
Hiroshi Nakano
Keyword(s):  
Mast Cell ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Preventive effect of Shigyaku-san on progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats

2006 ◽  
Vol 20 (4) ◽  
pp. 256-262 ◽  
Author(s):  
Yoshiji Ohta ◽  
Takashi Kobayashi ◽  
Takahiro Hayashi ◽  
Kazuo Inui ◽  
Junji Yoshino ◽  
...  
Keyword(s):  
Mast Cell ◽  
Preventive Effect ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Resistance of mast cell-deficient W/Wv mice to H.pylori -associated gastric mucosal lesions

2001 ◽  
Vol 120 (5) ◽  
pp. A650
Author(s):  
Hidekazu Suzuki ◽  
Masaharu Miyazawa ◽  
Akemi Kai ◽  
Soichiro Miura ◽  
Hiroshi Nagata ◽  
...  
Keyword(s):  
Mast Cell ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation

2021 ◽  
Vol 22 (11) ◽  
pp. 5983
Author(s):  
Mariano Ezequiel Vera ◽  
María Laura Mariani ◽  
Cristina Aguilera ◽  
Alicia Beatriz Penissi
Keyword(s):  
Animal Model ◽  
Mast Cell ◽  
Gastric Ulcer ◽  
Cell Activation ◽  
Repeated Administration ◽  
Mast Cell Activation ◽  
Gastric Erosion ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions ◽  
Serum Serotonin

The aim of this study was to determine whether the lactones dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one, would be effective in an animal model of gastric ulcer induced by mast cell activation. Rats were divided into ten groups. Treatments were repeated for four days. The degree of gastric erosion was assessed with a scoring system and histological preparations. Gastric mast cell morphology was analyzed by histological procedures. Serum serotonin levels were determined as markers of mast cell activation. Statistical analyses were done using ANOVA and Tukey–Kramer test. We demonstrated that the repeated administration of compound 48/80 results in extensive mucosal lesions in the gastric mucosa and that such lesions occurred in association with mast cell degranulation and a significant increase of serum serotonin. We showed that these lesions were prevented by dehydroleucodine, xanthatin, and 3-benzyloxymethyl-5H-furan-2-one and that this effect was similar to that obtained with sodium cromoglycate. In conclusion, the results of the present study indicate that the optimal gastric cytoprotective dose of dehydroleucodine, xanthatin, and 3-benzyloxymethyl-5H-furan-2-one is efficacious in an animal model of gastric ulcer induced by mast cell activation. Our findings suggest that these lactones could be valuable tools for designing novel therapeutic agents for digestive disorders associated with inappropriate mast cell activation.

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