scholarly journals GTS-21, a Nicotinic Agonist, Protects against Neocortical Neuronal Cell Loss Induced by the Nucleus Basalis Magnocellularis Lesion in Rats.

1997 ◽  
Vol 74 (3) ◽  
pp. 285-289 ◽  
Author(s):  
Masato Nanri ◽  
Nobuo Kasahara ◽  
Jyunji Yamamoto ◽  
Hidekazu Miyake ◽  
Hiroshi Watanabe
Keyword(s):  
Neuronal Cell ◽  
Cell Loss ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Neuronal Cell Loss ◽  
Nicotinic Agonist

Neuronal Cell Loss in the CA3 Subfield of the Hippocampus Following Cortical Contusion Utilizing the Optical Disector Method for Cell Counting

1997 ◽  
Vol 14 (6) ◽  
pp. 385-398 ◽  
Author(s):  
STANLEY A. BALDWIN ◽  
TONYA GIBSON ◽  
C. TODD CALLIHAN ◽  
PATRICK G. SULLIVAN ◽  
ERICK PALMER ◽  
...  
Keyword(s):  
Neuronal Cell ◽  
Cell Loss ◽  
Cell Counting ◽  
Optical Disector ◽  
Neuronal Cell Loss ◽  
Cortical Contusion

scholarly journals The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Ratchaniporn Kongsui ◽  
Napatr Sriraksa ◽  
Sitthisak Thongrong
Keyword(s):  
Proinflammatory Cytokine ◽  
Wistar Rats ◽  
Single Injection ◽  
Neuroprotective Effect ◽  
Neuronal Cell ◽  
Cell Loss ◽  
Neuronal Cell Loss ◽  
Male Wistar Rats ◽  
Astroglial Activation ◽  
Zingiber Cassumunar

The systemic administration of lipopolysaccharide (LPS) has been recognized to induce neuroinflammation which plays a significant role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In this study, we aimed to determine the protective effect of Zingiber cassumunar (Z. cassumunar) or Phlai (in Thai) against LPS-induced neuronal cell loss and the upregulation of glial fibrillary acidic protein (GFAP) of astrocytes in the hippocampus. Adult male Wistar rats were orally administered with Z. cassumunar extract at various doses (50, 100, and 200 mg/kg body weight) for 14 days before a single injection of LPS (250 μg/kg/i.p.). The results indicated that LPS-treated animals exhibited neuronal cell loss and the activation of astrocytes and also increased proinflammatory cytokine interleukin- (IL-) 1β in the hippocampus. Pretreatment with Z. cassumunar markedly reduced neuronal cell loss in the hippocampus. In addition, Z. cassumunar extract at a dose of 200 mg/kg BW significantly suppressed the inflammatory response by reducing the expression of GFAP and IL-1ß in the hippocampus. Therefore, the results suggested that Z. cassumunar extract might be valuable as a neuroprotective agent in neuroinflammation-induced brain damage. However, further investigations are essential to validate the possible active ingredients and mechanisms of its neuroprotective effect.

scholarly journals Down-regulation of microglial activity attenuates axotomized nigral dopaminergic neuronal cell loss

2013 ◽  
Vol 14 (1) ◽  
pp. 112 ◽  
Author(s):  
Dae-Yong Song ◽  
Ha-Nul Yu ◽  
Chae-Ri Park ◽  
Jin-Sook Lee ◽  
Ji-Yong Lee ◽  
...  
Keyword(s):  
Neuronal Cell ◽  
Cell Loss ◽  
Down Regulation ◽  
Dopaminergic Neuronal Cell ◽  
Neuronal Cell Loss
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