scholarly journals Greater Contraction Is Induced by Pilocarpine than by Carbachol at the Same Levels of Cytosolic Ca2 + Concentration in Isolated Longitudinal Muscle of Guinea Pig Ileum

1990 ◽  
Vol 53 (4) ◽  
pp. 525-527 ◽  
Author(s):  
Issei TAKAYANAGI ◽  
Hiroshi OHTSUKI
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Guinea Pig Ileum

Somatostatin modulation of peptide-induced acetylcholine release in guinea pig ileum

1984 ◽  
Vol 246 (5) ◽  
pp. G509-G514 ◽  
Author(s):  
D. H. Teitelbaum ◽  
T. M. O'Dorisio ◽  
W. E. Perkins ◽  
T. S. Gaginella
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Longitudinal Muscle ◽  
Guinea Pig Ileum ◽  
Gut Motility ◽  
Release Of Acetylcholine

The peptides caerulein, neurotensin, somatostatin, and substance P modulate the activity of intestinal neurons and alter gut motility. We examined the effects of these peptides on acetylcholine release from the myenteric plexus and intestinal contractility in vitro. Caerulein (1 X 10(-9) M), neurotensin (1.5 X 10(-6) M), and substance P (1 X 10(-7) M) significantly enhanced the release of [3H]acetylcholine from the myenteric plexus of the guinea pig ileum. This effect was inhibited by tetrodotoxin (1.6 X 10(-6) M). Somatostatin (10(-6) M) inhibited caerulein- and neurotensin-evoked release of acetylcholine but did not inhibit release induced by substance P. Caerulein, neurotensin, and substance P caused contraction of the guinea pig ileal longitudinal muscle. Somatostatin inhibited the contractions induced by caerulein and neurotensin. In contrast, substance P-induced contraction was not inhibited significantly by somatostatin. Thus, in the guinea pig ileum, caerulein-, neurotensin-, and substance P-induced contractility is due, at least in part, to acetylcholine release from the myenteric plexus. The ability of somatostatin to inhibit peptide-induced contractility is selective, and its mechanism may be attributed to inhibition of acetylcholine release.

K+ channel openers relax longitudinal muscle of guinea pig ileum

1994 ◽  
Vol 271 (2-3) ◽  
pp. 453-459 ◽  
Author(s):  
Ya-Ding Sun ◽  
Christina G. Benishin
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
K Channel ◽  
Guinea Pig Ileum
Sign in / Sign up

Export Citation Format

Share Document