Differential effects of SKF 10,047 (N-allyl-normetazocine) on peristalsis and longitudinal muscle contractions of the isolated guinea-pig ileum

1982 ◽  
Vol 321 (3) ◽  
pp. 218-222 ◽  
Author(s):  
W. Kromer ◽  
N. Steigemann ◽  
G. T. Shearman
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Muscle Contractions ◽  
Guinea Pig Ileum ◽  
Differential Effects

Somatostatin modulation of peptide-induced acetylcholine release in guinea pig ileum

1984 ◽  
Vol 246 (5) ◽  
pp. G509-G514 ◽  
Author(s):  
D. H. Teitelbaum ◽  
T. M. O'Dorisio ◽  
W. E. Perkins ◽  
T. S. Gaginella
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Longitudinal Muscle ◽  
Guinea Pig Ileum ◽  
Gut Motility ◽  
Release Of Acetylcholine

The peptides caerulein, neurotensin, somatostatin, and substance P modulate the activity of intestinal neurons and alter gut motility. We examined the effects of these peptides on acetylcholine release from the myenteric plexus and intestinal contractility in vitro. Caerulein (1 X 10(-9) M), neurotensin (1.5 X 10(-6) M), and substance P (1 X 10(-7) M) significantly enhanced the release of [3H]acetylcholine from the myenteric plexus of the guinea pig ileum. This effect was inhibited by tetrodotoxin (1.6 X 10(-6) M). Somatostatin (10(-6) M) inhibited caerulein- and neurotensin-evoked release of acetylcholine but did not inhibit release induced by substance P. Caerulein, neurotensin, and substance P caused contraction of the guinea pig ileal longitudinal muscle. Somatostatin inhibited the contractions induced by caerulein and neurotensin. In contrast, substance P-induced contraction was not inhibited significantly by somatostatin. Thus, in the guinea pig ileum, caerulein-, neurotensin-, and substance P-induced contractility is due, at least in part, to acetylcholine release from the myenteric plexus. The ability of somatostatin to inhibit peptide-induced contractility is selective, and its mechanism may be attributed to inhibition of acetylcholine release.

K+ channel openers relax longitudinal muscle of guinea pig ileum

1994 ◽  
Vol 271 (2-3) ◽  
pp. 453-459 ◽  
Author(s):  
Ya-Ding Sun ◽  
Christina G. Benishin
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
K Channel ◽  
Guinea Pig Ileum

Substance P-evoked circular muscle contractions have a close connection with serotonergic neurons in guinea-pig ileum

1993 ◽  
Vol 46 (1-2) ◽  
pp. 379-380
Author(s):  
Toshiaki Ohmori ◽  
Atsukazu Kuwahara ◽  
Tsuyoshi Ozaki ◽  
Noboru Yanaihara ◽  
Yasuo Takeda ◽  
...  
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Circular Muscle ◽  
Muscle Contractions ◽  
Close Connection ◽  
Guinea Pig Ileum ◽  
Serotonergic Neurons
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