scholarly journals Effect of a Novel CNS-Selective Cholinesterase Inhibitor, SM-10888, on Habituation and Passive Avoidance Responses in Mice

1990 ◽  
Vol 53 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Yuko OKAZAKI ◽  
Kazuichi NATORI ◽  
Tsunemasa IRlE ◽  
Junki KATSUBE
Keyword(s):  
Passive Avoidance ◽  
Cholinesterase Inhibitor ◽  
Avoidance Responses

Effects of Large and Small Bilateral Hippocampal Lesions on Two Types of Passive-Avoidance Responses

1965 ◽  
Vol 16 (3_suppl) ◽  
pp. 1277-1290 ◽  
Author(s):  
Daniel R. Snyder ◽  
Robert L. Isaacson
Keyword(s):  
Passive Avoidance ◽  
Food Reward ◽  
Dorsal Hippocampus ◽  
Passive Avoidance Task ◽  
The Other ◽  
Hippocampal Damage ◽  
Avoidance Task ◽  
Small Compartment ◽  
Hippocampal Lesions ◽  
Avoidance Responses

Ten rats with large bilateral hippocampectomies, 10 rats with smaller amounts of damage of the dorsal hippocampus, 10 rats with destruction of postero-lateral neocortex, and 15 normal animals were trained in two types of passive-avoidance situations. One passive-avoidance task required inhibition of drinking while thirsty, the other required an animal to refrain from entering a small compartment after i: had been trained to enter, while hungry, for a food reward. Animals with the largest amounts of hippocampal destruction were impaired in both types of problems. Animals with smaller degrees of hippocampal damage were not different from normal animals in their ability to inhibit licking but were impaired in the other task. Animals with neocortical destruction showed impairment only in the licking situation.

Prolongation of latencies for passive avoidance responses in rats treated with aniracetam or piracetam

1985 ◽  
Vol 22 (4) ◽  
pp. 645-648 ◽  
Author(s):  
Katsushi Yamada ◽  
Takato Inoue ◽  
Mariko Tanaka ◽  
Tatsuo Furukawa
Keyword(s):  
Passive Avoidance ◽  
Avoidance Responses

Memory effect of caerulein and its analogs in active and passive avoidance responses in the rat

Peptides ◽  
1989 ◽  
Vol 10 (4) ◽  
pp. 843-848 ◽  
Author(s):  
Shinji Itoh ◽  
Akira Takashima ◽  
Ken'ichi Igano ◽  
Ken Inouye
Keyword(s):  
Passive Avoidance ◽  
Memory Effect ◽  
Avoidance Responses

Cholinesterase Inhibitor 6-Chlorotacrine - In Vivo Toxicological Profile and Behavioural Effects

2018 ◽  
Vol 15 (6) ◽  
pp. 552-560 ◽  
Author(s):  
Jan Misik ◽  
Eugenie Nepovimova ◽  
Jaroslav Pejchal ◽  
Jiri Kassa ◽  
Jan Korabecny ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Cholinesterase Inhibitor ◽  
Water Maze ◽  
Parent Compound ◽  
Female Rats ◽  
Passive Avoidance Test ◽  
Avoidance Test ◽  
Maze Test ◽  
Behavioural Effects

Background: 6-chlorotacrine is a cholinesterase inhibitor showing good inhibitory potential, even better than parent compound tacrine, in vitro. Despite tacrine scaffold is broadly used for design and synthesis of novel compounds with anti-Alzheimer's potential, no in vivo effects have been investigated so far. Thus, basic toxicological and behavioural evaluation has been carried out throughout this study. Methods: Maximum tolerated dose (MTD) and median lethal dose (LD50) were assessed in BALB/c mice and Wistar rats. Behavioural effects were observed in rats performing the multiple T-maze test, the water maze test and the step-through passive avoidance test. All outcomes were compared with the effects of parent compound - tacrine. Results: The toxicity of 6-chlorotacrine was increased compared to tacrine with MTD 6.0/5.0 mg.kg-1 (i.m., male/female mice), 6.0/5.0 mg.kg-1 (i.p., male/female rats) and LD50 9.0 mg.kg-1 (male rats). At MTD doses, no histopathological changes and blood biochemistry abnormalities were observed except decreased plasma creatinine levels. 6-chlorotacrine showed good effects in the reversal of quinuclidinyl benzilate-induced amnesia. Best results were achieved at the dose of 1.8 mg.kg-1 (20% LD50) in the water maze test; the pro-cognitive effect was stronger than that of tacrine (5.2 mg.kg-1, 20% LD50). Other doses tested (0.9 mg.kg-1 and 2.7 mg.kg-1) showed similar effects as tacrine in the water maze, multiple T-maze and passive avoidance test. Conclusion: Observed effects predetermined 6-chlorotacrine as a potent parent compound for the synthesis of novel multifactorial drugs intended to the treatment of Alzheimer's disease. Even though 6- chlorotacrine showed in vivo beneficial effect with no signs of toxicity, further tests on the field of biochemistry and pharmacology are essential to disclose the exact mechanism of action, safety evaluation and the metabolic fate of the compound after the repeated administration.

Effects of chlordiazepoxide on passive avoidance responses in rats

1972 ◽  
Vol 23 (4) ◽  
pp. 373-385 ◽  
Author(s):  
Hiroshi Oishi ◽  
Shinkuro Iwahara ◽  
Kwo-Man Yang ◽  
Akiko Yogi
Keyword(s):  
Passive Avoidance ◽  
Avoidance Responses

Minaprine cancels scopolamine effects on the rat's acquisition of passive avoidance responses in two multitrial paradigms

1992 ◽  
Vol 41 (4) ◽  
pp. 715-718 ◽  
Author(s):  
Carlo Ambrogi Lorenzini ◽  
Elisabetta Baldi ◽  
Corrado Bucherelli ◽  
Giovanna Tassoni
Keyword(s):  
Passive Avoidance ◽  
Avoidance Responses
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