scholarly journals An antagonistic activity of etizolam on platelet-activating factor(PAF). In vitro effects on platelet aggregation and PAF receptor binding.

1987 ◽  
Vol 44 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Hiroshi MIKASHIMA ◽  
Shuzo TAKEHARA ◽  
Yoshito MURAMOTO ◽  
Takako KHOMARU ◽  
Michio TERASAWA ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Receptor Binding ◽  
Platelet Activating Factor ◽  
Antagonistic Activity ◽  
Paf Receptor ◽  
In Vitro Effects

scholarly journals An Antagonistic Activity of Etizolam on Platelet-Activating Factor (PAF) In Vitro Effects on Platelet Aggregation and PAF Receptor Binding

1987 ◽  
Vol 44 (4) ◽  
pp. 387-391
Author(s):  
Hiroshi MIKASHIMA ◽  
Shüzö TAKEHARA ◽  
Yoshito MURAMOTO ◽  
Takako KHOMARU ◽  
Michio TERASAWA ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Receptor Binding ◽  
Platelet Activating Factor ◽  
Antagonistic Activity ◽  
Paf Receptor ◽  
In Vitro Effects

scholarly journals In Vitro Antithrombotic Properties of Salmon (Salmo salar) Phospholipids in a Novel Food-Grade Extract

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 62 ◽  
Author(s):  
Alexandros Tsoupras ◽  
Ronan Lordan ◽  
Katie Shiels ◽  
Sushanta Saha ◽  
Constantina Nasopoulou ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Salmo Salar ◽  
Platelet Activating Factor ◽  
Human Platelets ◽  
Food Grade ◽  
Farmed Salmon ◽  
Lipid Fractions ◽  
Antithrombotic Effects ◽  
Layer Chromatography

Marine and salmon polar lipids (PLs) extracted by conventional extractions with non-food-grade solvents (CE-salmon-PLs) possess antithrombotic bioactivities against platelet-activating factor (PAF) and thrombin. Similar effects of food-grade-extracted (FGE) marine PLs have not yet been reported. In this study, food-grade solvents were used to extract PLs from Irish organic farmed salmon (Salmo salar) fillets (FGE-salmon-PLs), while their antithrombotic bioactivities were assessed in human platelets induced by platelet aggregation agonists (PAF/thrombin). FGE-salmon-PLs were further separated by thin layer chromatography (TLC) into lipid subclasses, and the antithrombotic bioactivities of each subclass were also assessed. LC-MS was utilized to elucidate the structure-activity relationships. FGE-salmon-PLs strongly inhibited PAF-induced platelet aggregation, while their relevant anti-thrombin effects were at least three times more potent than the previously reported activities of CE-salmon-PLs. TLC-derived lipid fractions corresponding to phosphatidylcholines (PC) and phosphatidylethanolamines (PE) were the most bioactive lipid subclasses obtained, especially against thrombin. Their LC-MS analysis elucidated that they are diacyl- or alkyl-acyl- PC and PE moieties baring ω3 polyunsaturated fatty acids (PUFA) at their sn-2 position, such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Our results concerning the potent antithrombotic effects of FGE-salmon-PLs against both PAF and thrombin pathways strongly suggest that such food-grade extracts are putative candidates for the development of novel cardioprotective supplements and nutraceuticals.

scholarly journals Expression of Phosphorylcholine by Histophilus somni Induces BovinePlatelet Aggregation

2006 ◽  
Vol 75 (2) ◽  
pp. 1045-1049 ◽  
Author(s):  
Christopher J. Kuckleburg ◽  
Shaadi F. Elswaifi ◽  
Thomas J. Inzana ◽  
Charles J. Czuprynski
Keyword(s):  
Platelet Aggregation ◽  
Platelet Activating Factor ◽  
Induce Platelet Aggregation ◽  
Histophilus Somni ◽  
Paf Receptor ◽  
Induced Aggregation

ABSTRACT Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP− H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.

Synthesis and In vitro platelet aggregation and TP receptor binding studies on bicyclic 5,8-Ethanooctahydroisoquinolines and 5,8-Ethanotetrahydroisoquinolines

2002 ◽  
Vol 10 (8) ◽  
pp. 2779-2793 ◽  
Author(s):  
Shankar L Saha ◽  
Victoria F Roche ◽  
Kathleen Pendola ◽  
Mark Kearley ◽  
Longping Lei ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Receptor Binding ◽  
Binding Studies ◽  
Tp Receptor

In vitro effects of estetrol on receptor binding, drug targets and human liver cell metabolism

Climacteric ◽  
2008 ◽  
Vol 11 (sup1) ◽  
pp. 64-68 ◽  
Author(s):  
M. Visser ◽  
J.-M. Foidart ◽  
H. J. T. Coelingh Bennink
Keyword(s):  
Receptor Binding ◽  
Liver Cell ◽  
Human Liver ◽  
Drug Targets ◽  
Cell Metabolism ◽  
Human Liver Cell ◽  
In Vitro Effects
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