scholarly journals Involvement of Endogenous Noradrenaline Release in Methylene Blue-Induced Contraction of Isolated Rabbit Aorta

1987 ◽  
Vol 44 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Isao MATSUOKA ◽  
Kunio SAKURAI ◽  
Tomoyuki ONO ◽  
Hironori NAKANISHI
Keyword(s):  
Methylene Blue ◽  
Noradrenaline Release ◽  
Rabbit Aorta ◽  
Endogenous Noradrenaline ◽  
Isolated Rabbit Aorta

scholarly journals QUALITATIVELY DIFFERENT RESPONSE OF ISOLATED RABBIT AORTA TO METHYLENE BLUE ADMINISTERED FROM INTIMAL AND ADVENTITIAL SURFACE

2001 ◽  
Vol 47 (2) ◽  
pp. 63-73 ◽  
Author(s):  
HIRONORI NAKANISHI ◽  
ISAO MATSUOKA ◽  
TOMOYUKI ONO ◽  
SATOKO OHKUBO ◽  
NORIMICHI NAKAHATA
Keyword(s):  
Methylene Blue ◽  
Rabbit Aorta ◽  
Isolated Rabbit Aorta ◽  
Different Response

scholarly journals Pharmacological Effects ofLactuca serriolaL. in Experimental Model of Gastrointestinal, Respiratory, and Vascular Ailments

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Khalid Hussain Janbaz ◽  
Muhammad Farhaj Latif ◽  
Fatima Saqib ◽  
Imran Imran ◽  
M. Zia-Ul-Haq ◽  
...  
Keyword(s):  
Muscarinic Receptors ◽  
Channel Blocker ◽  
Methanol Extract ◽  
Contractile Response ◽  
Rabbit Aorta ◽  
Pharmacological Effects ◽  
Response Curves ◽  
Lactuca Serriola ◽  
Rabbit Jejunum ◽  
Isolated Rabbit Aorta

Lactuca serriolaL. has traditionally been used in folkloric medicine to manage respiratory, gastrointestinal, and multiple other ailments. The present study was undertaken to explore the effect of methanol extract ofL. serriolaon isolated rabbit tissue preparations, that is, jejunum, trachea, and aorta in an attempt to validate its folkloric use in traditional medicine for gastrointestinal, respiratory, and vascular ailments. The application of the methanol extract to isolated rabbit jejunum preparations exhibited concentration-dependent spasmogenic effect (0.03 to 3.0 mg/mL), but interestingly further increase in concentration (5.0 mg/mL) resulted in complete spasmolytic effect. The pretreatment of the tissue preparations with atropine (0.1 μM) caused the suppression of the contractile response. Moreover, the same extract also caused relaxation of K+-(80 mM) induced spastic contractions of isolated rabbit jejunum preparations (5.0 mg/mL) and shifted the Ca++dose response curves towards right at concentration range of 0.3–1.0 mg/mL. Similarly, the extract application to isolated rabbit tracheal preparations relaxed the carbachol-(1 μM) induced (0.3–1.0 mg/mL) as well as K+-(80 mM) induced contractions (3.0 mg/mL). Furthermore, it relaxed the phenylephrine (1 μM)-induced contractions in isolated rabbit aorta preparations (3.0 mg/mL) and K+(80 mM)-induced contractions (1.0 mg/mL). These effects were found comparable to that of dicyclomine, as an antagonist of muscarinic receptors as well as a possible Ca++channel blocker. The previously mentioned findings may partially justify the folkloric use ofLactuca serriolain the management of conditions pertaining to spasm of intestine, bronchioles, and vasculature.

scholarly journals Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors

2020 ◽  
Vol 30 (12) ◽  
pp. 6135-6151 ◽  
Author(s):  
Travis J Bacon ◽  
Anthony E Pickering ◽  
Jack R Mellor
Keyword(s):  
Noradrenaline Release ◽  
Information Transfer ◽  
Pyramidal Neurons ◽  
Schaffer Collateral ◽  
Release Of Noradrenaline ◽  
Ca1 Pyramidal Neurons ◽  
Endogenous Noradrenaline ◽  
Memory Representations ◽  
Endogenous Release ◽  
Ca1 Pyramidal Neuron

Abstract Release of the neuromodulator noradrenaline signals salience during wakefulness, flagging novel or important experiences to reconfigure information processing and memory representations in the hippocampus. Noradrenaline is therefore expected to enhance hippocampal responses to synaptic input; however, noradrenergic agonists have been found to have mixed and sometimes contradictory effects on Schaffer collateral synapses and the resulting CA1 output. Here, we examine the effects of endogenous, optogenetically driven noradrenaline release on synaptic transmission and spike output in mouse hippocampal CA1 pyramidal neurons. We show that endogenous noradrenaline release enhances the probability of CA1 pyramidal neuron spiking without altering feedforward excitatory or inhibitory synaptic inputs in the Schaffer collateral pathway. β-adrenoceptors mediate this enhancement of excitation-spike coupling by reducing the charge required to initiate action potentials, consistent with noradrenergic modulation of voltage-gated potassium channels. Furthermore, we find the likely effective concentration of endogenously released noradrenaline is sub-micromolar. Surprisingly, although comparable concentrations of exogenous noradrenaline cause robust depression of slow afterhyperpolarization currents, endogenous release of noradrenaline does not, indicating that endogenous noradrenaline release is targeted to specific cellular locations. These findings provide a mechanism by which targeted endogenous release of noradrenaline can enhance information transfer in the hippocampus in response to salient events.

scholarly journals Characterization of endogenous noradrenaline release from intact and epithelium-denuded rat isolated trachea

1991 ◽  
Vol 103 (1) ◽  
pp. 1213-1217 ◽  
Author(s):  
Kurt Racké ◽  
Astrid Bähring ◽  
Gernot Brunn ◽  
Mathias Eisner ◽  
Ignaz Wessler
Keyword(s):  
Noradrenaline Release ◽  
Endogenous Noradrenaline ◽  
Isolated Trachea
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