Prejunctional modulation by angiotensins of noradrenaline release from sympathetic neurons in isolated rabbit aorta

1997 ◽  
Vol 356 (6) ◽  
pp. 706-711 ◽  
Author(s):  
Tore Storgaard ◽  
O. A. Nedergaard
Keyword(s):  
Noradrenaline Release ◽  
Sympathetic Neurons ◽  
Rabbit Aorta ◽  
Isolated Rabbit Aorta

scholarly journals Pharmacological Effects ofLactuca serriolaL. in Experimental Model of Gastrointestinal, Respiratory, and Vascular Ailments

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Khalid Hussain Janbaz ◽  
Muhammad Farhaj Latif ◽  
Fatima Saqib ◽  
Imran Imran ◽  
M. Zia-Ul-Haq ◽  
...  
Keyword(s):  
Muscarinic Receptors ◽  
Channel Blocker ◽  
Methanol Extract ◽  
Contractile Response ◽  
Rabbit Aorta ◽  
Pharmacological Effects ◽  
Response Curves ◽  
Lactuca Serriola ◽  
Rabbit Jejunum ◽  
Isolated Rabbit Aorta

Lactuca serriolaL. has traditionally been used in folkloric medicine to manage respiratory, gastrointestinal, and multiple other ailments. The present study was undertaken to explore the effect of methanol extract ofL. serriolaon isolated rabbit tissue preparations, that is, jejunum, trachea, and aorta in an attempt to validate its folkloric use in traditional medicine for gastrointestinal, respiratory, and vascular ailments. The application of the methanol extract to isolated rabbit jejunum preparations exhibited concentration-dependent spasmogenic effect (0.03 to 3.0 mg/mL), but interestingly further increase in concentration (5.0 mg/mL) resulted in complete spasmolytic effect. The pretreatment of the tissue preparations with atropine (0.1 μM) caused the suppression of the contractile response. Moreover, the same extract also caused relaxation of K+-(80 mM) induced spastic contractions of isolated rabbit jejunum preparations (5.0 mg/mL) and shifted the Ca++dose response curves towards right at concentration range of 0.3–1.0 mg/mL. Similarly, the extract application to isolated rabbit tracheal preparations relaxed the carbachol-(1 μM) induced (0.3–1.0 mg/mL) as well as K+-(80 mM) induced contractions (3.0 mg/mL). Furthermore, it relaxed the phenylephrine (1 μM)-induced contractions in isolated rabbit aorta preparations (3.0 mg/mL) and K+(80 mM)-induced contractions (1.0 mg/mL). These effects were found comparable to that of dicyclomine, as an antagonist of muscarinic receptors as well as a possible Ca++channel blocker. The previously mentioned findings may partially justify the folkloric use ofLactuca serriolain the management of conditions pertaining to spasm of intestine, bronchioles, and vasculature.

α2-Adrenoceptor-Mediated Inhibition of Electrically Evoked [3H]Noradrenaline Release from Chick Sympathetic Neurons: Role of Cyclic AMP

2002 ◽  
Vol 63 (1) ◽  
pp. 146-154 ◽  
Author(s):  
Stefan Boehm ◽  
Sigismund Huck ◽  
Gabriele Koth ◽  
Helmut Drobny ◽  
Ernst Agneter ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Noradrenaline Release ◽  
Sympathetic Neurons ◽  
Α2 Adrenoceptor

α1-Adrenoceptors induce Ca influx and intracellular Ca release in isolated rabbit aorta

1982 ◽  
Vol 84 (3-4) ◽  
pp. 233-235 ◽  
Author(s):  
C. Cauvin ◽  
R. Loutzenhiser ◽  
O. Hwang ◽  
C. Van Breemen
Keyword(s):  
Rabbit Aorta ◽  
Intracellular Ca ◽  
Isolated Rabbit Aorta
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