scholarly journals Impairment of Acid-Neutralizing Capacity and Lesion Formation in the Rat Duodenum during Hemorrhagic Shock: Comparative Study with Indomethacin

1987 ◽  
Vol 44 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Koji TAKEUCHI ◽  
Osamu FURUKAWA ◽  
Hironori TANAKA ◽  
Hideyuki NISHIWAKI ◽  
Susumu OKABE
Keyword(s):  
Comparative Study ◽  
Hemorrhagic Shock ◽  
Acid Neutralizing Capacity ◽  
Lesion Formation ◽  
Neutralizing Capacity ◽  
Rat Duodenum

Determination of acid-neutralizing capacity in rat duodenum

1986 ◽  
Vol 31 (6) ◽  
pp. 631-637 ◽  
Author(s):  
Koji Takeuchi ◽  
Osamu Furukawa ◽  
Hironori Tanaka ◽  
Susumu Okabe
Keyword(s):  
Acid Neutralizing Capacity ◽  
Neutralizing Capacity ◽  
Rat Duodenum

Evaluation of Hemidesmus indicus root as an antacid by In vitro

2016 ◽  
Vol 5 (04) ◽  
pp. 4524
Author(s):  
Abdullah Shaikh Farooque ◽  
Md. Azharuddin Ismail Atar*
Keyword(s):  
Skin Diseases ◽  
Care Delivery ◽  
Health Care Delivery System ◽  
Acid Neutralizing Capacity ◽  
Standard Drug ◽  
Hemidesmus Indicus ◽  
Neutralizing Capacity ◽  
Loss Of Appetite ◽  
Powdered Drug

Medicinal plants are being widely used, either as single drug or in combination in health care delivery system. Indian Sarsaparilla, Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant, which is widely recognized in traditional systems of Medicine. It contains various phytoconstituents belonging to the category glycosides, flavonoids, tannins, sterols and volatile oils. It has been reported as useful in biliousness, blood diseases, dysentery, diarrhea, respiratory disorders, skin diseases, syphilis, fever, leprosy, leucoderma, leucorrhoea, itching, bronchitis, asthma, eye diseases, epileptic fits in children, kidney and urinary disorders, loss of appetite, burning sensation, dyspepsia, nutritional disorders, ulcer and rheumatism. Several studies are being carried towards its activities like analgesic, anti-inflammatory, antiulcer, hepatoprotective, antioxidant and helicobactericidal properties. In our study we have evaluated antacid activity of sariva (Anantmool) by using In-Vitro method, i.e. ANC (Acid Neutralizing Capacity). This evaluation was done by comparing the ANC of sariva macerated & powdered drug with water as blank & standard drug i.e. NaHCO3. Based on this In-Vitro experiment, we can conclude that, the macerated & powdered drug of sariva (Anantmool) evaluated in this study, varied in potency as measured in terms of their ANC. These results having ** i.e. P < 0.01 & Passed the normality test. However, the present study being in-vitro, the effects of antacid may vary In-Vitro; individual variations also contribute to the ultimate effectiveness of as antacid.        

scholarly journals In-vitro antiulcer activities of petal extract of Crocus sativus var. cashmerianus

2020 ◽  
pp. 6-8
Author(s):  
Vijender Kumar ◽  
Poonam Verma ◽  
Amarjit Kaur ◽  
Baljinder Singh
Keyword(s):  
Crocus Sativus ◽  
Acid Neutralizing Capacity ◽  
Inhibition Activity ◽  
Similar Dose ◽  
Neutralizing Capacity ◽  
Activity Method ◽  
Atpase Inhibition ◽  
Acid Neutralize ◽  
Capacity Method

Medicinal plants have been known for millennia as a rich source of traditional therapeutic agents for the prevention of diseases and ailments. The aim of the present study was performed to evaluate the antiulcer activities of hydro-alcoholic extracts of petals of Crocus sativus var. Cashmerianus by in-vitro methods viz. acid neutralizing capacity and H+/K+ - ATPase inhibition activity. In acid neutralizing capacity method, the petals extract significantly reduced acidity to 6.10 at a concentration of 1000 mg/ml as compared to 11.90 with standard 500 mg/ml of Aluminium hydroxide + Magnesium hydroxide combination. However, H+/K+ - ATPase inhibition activity method, petals extract showed maximum percentage inhibition of 70.31 % at the concentration 400µg/ml as compared to 73.82 % with a similar dose of standard Omeprazole. The IC 50 value of petals extract of C. sativus var. cashmerianus is shown 100 µg/ml in comparison with standard omeprazole of 82.5 µg/ml. The study reveals that the petals extract of C. sativus var. cashmerianus may contain compounds possessing acid neutralize and enzyme inhibition activities, thus it can be used as an alternative medicine for gastrointestinal disorders.

scholarly journals RANITIDINE CONTROLLED RELEASE ANTI-REFLUX SUSPENSION FOR GASTRO-OESOPHAGEAL REFLUX DISEASE AND IT’S IN VITRO EVALUATION

2019 ◽  
Vol 11 (1) ◽  
pp. 74
Author(s):  
Sangmesh R. Torne ◽  
Sheela A. ◽  
Sarada N. C.
Keyword(s):  
Controlled Release ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Gelling Agent ◽  
Acid Neutralizing Capacity ◽  
Simulated Gastric Fluid ◽  
In Vitro Evaluation ◽  
Oesophageal Reflux Disease ◽  
Neutralizing Capacity

Objective: The aim of this work was to develop triple action controlled release anti-reflux suspension of ranitidine and its in-vitro evaluation of anti-reflux and controlled release properties.Methods: The formulation was optimized using sodium alginate as a gelling agent along with calcium carbonate, sodium bicarbonate, magnesium hydroxide, aluminium hydroxide as alkalizing agents and colloidal microcrystalline cellulose (MCC) as a suspending agent at various concentrations and arrived at an optimized formulation for its best quality attributes. To avoid initial release in water before administration, ranitidine coated MCC sphere was incorporated into powder formulation and subjected to in vitro characteristics like raft strength, acid neutralizing capacity, pH, viscosity and dissolution study. The obtained results were assessed using Minitab 17 statistical software to conclude the study design.Results: Formulation containing 300 mg of ranitidine along with 750 mg alginate has shown better anti-reflux characteristics like raft strength 18±2g, acid neutralizing capacity 17±1 mEq compared to other formulations. This formulation has also shows zero-order controlled release in the simulated gastric fluid (SGF) up to 10 h compared to the formulation without alginate. Further, to this optimized formulation has shown negligible change in the assay of ranitidine even after 3 mo at 40 °C temperature and 75% RH.Conclusion: The developed stable sustained release powder for suspension has the combined therapeutic efficacy as an antacid and anti-reflux drug suitable for the management and treatment of gastro-oesophageal reflux disease (GERD) unlike the existing drugs possessing only reflux resistance action.

scholarly journals Inventory of MSWI Fly Ash in Switzerland: Heavy Metal Recovery Potential and Their Properties for Acid Leaching

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1668
Author(s):  
Wolfgang Zucha ◽  
Gisela Weibel ◽  
Mirjam Wolffers ◽  
Urs Eggenberger
Keyword(s):  
Heavy Metals ◽  
Fly Ash ◽  
Acid Leaching ◽  
Acid Neutralizing Capacity ◽  
Mswi Fly Ash ◽  
Mineralogical Characterization ◽  
Recovery Rates ◽  
Leaching Potential ◽  
Geochemical Properties ◽  
Neutralizing Capacity

From the year 2021 on, heavy metals from Swiss municipal solid waste incineration (MSWI) fly ash (FA) must be recovered before landfilling. This is predominantly performed by acid leaching. As a basis for the development of defined recovery rates and for the implementation of the recovery process, the authorities and plant operators need information on the geochemical properties of FA. This study provides extended chemical and mineralogical characterization of all FA produced in 29 MSWI plants in Switzerland. Acid neutralizing capacity (ANC) and metallic aluminum (Al0) were additionally analyzed to estimate the effort for acid leaching. Results show that all FA samples are composed of similar constituents, but their content varies due to differences in waste input and incineration conditions. Based on their geochemical properties, the ashes could be divided into four types describing the leachability: very good (6 FA), good (10 FA), moderate (5 FA), and poor leaching potential (8 FA). Due to the large differences it is suggested that the required recovery rates are adjusted to the leaching potential. The quantity of heavy metals recoverable by acid leaching was estimated to be 2420 t/y Zn, 530 t/y Pb, 66 t/y Cu and 22 t/y Cd.

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