Determination of acid-neutralizing capacity in rat duodenum

1986 ◽  
Vol 31 (6) ◽  
pp. 631-637 ◽  
Author(s):  
Koji Takeuchi ◽  
Osamu Furukawa ◽  
Hironori Tanaka ◽  
Susumu Okabe
Keyword(s):  
Acid Neutralizing Capacity ◽  
Neutralizing Capacity ◽  
Rat Duodenum

scholarly journals Preliminary in-vitro evaluation of marketed formulations for antacid activity

2019 ◽  
Vol 9 (1) ◽  
pp. 57
Author(s):  
Pranjali P. Dhawal ◽  
Siddhivinayak S. Barve
Keyword(s):  
Acid Neutralizing Capacity ◽  
Acid Base ◽  
Time Duration ◽  
Neutralizing Capacity ◽  
Neutralizing Potential ◽  
The Given ◽  
Expensive Process ◽  
Hcl Solution

Background: Hydrochloric acid (pH 1.5-3.5) being the major component of gastric acid is produced by parietal cells of stomach. Its secretion is a complex and relatively energetically expensive process. The preservation of acidity of stomach is evidently important because of its implications in peptic and duodenal ulceration.Methods: In the present study, we attempted to compare the activity of 13 (F1-F13) antacid formulations (5-liquid, 4- quick releases and 4- tablets) by using acid-base neutralization studies. Preliminary antacid test (PAT) was performed to define whether the given formulation falls under the category of antacid wherein the pH of the antacid-acid (HCl) solution should be higher than pH of 3.5. The chosen antacids were further subjected to acid neutralizing capacity (ANC) (reaction between the sample of antacid and amount of acid neutralized by the formulation) and acid neutralizing potential (ANP) which explains the time duration during which a given sample of antacid can maintain pH above 3.5).Results: Out of the 13 samples tested, two formulations of pastels (F6, F12) were rejected as per the standard protocol of classifying formulations as antacids after screening for PAT. Sample F5 was found to have the highest ANC. F7 also showed highest ANC among the tablets tested. Also, F13 showed better ANC and ANP as in comparison to other quick releases.Conclusions: Digene products (F5, F7, and F13) showed better antacid properties. This data would provide insights into development of drug, comparison between antacids depending on their chemical formulation and determination of dosage to avoid plausible side effects.

Evaluation of Hemidesmus indicus root as an antacid by In vitro

2016 ◽  
Vol 5 (04) ◽  
pp. 4524
Author(s):  
Abdullah Shaikh Farooque ◽  
Md. Azharuddin Ismail Atar*
Keyword(s):  
Skin Diseases ◽  
Care Delivery ◽  
Health Care Delivery System ◽  
Acid Neutralizing Capacity ◽  
Standard Drug ◽  
Hemidesmus Indicus ◽  
Neutralizing Capacity ◽  
Loss Of Appetite ◽  
Powdered Drug

Medicinal plants are being widely used, either as single drug or in combination in health care delivery system. Indian Sarsaparilla, Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant, which is widely recognized in traditional systems of Medicine. It contains various phytoconstituents belonging to the category glycosides, flavonoids, tannins, sterols and volatile oils. It has been reported as useful in biliousness, blood diseases, dysentery, diarrhea, respiratory disorders, skin diseases, syphilis, fever, leprosy, leucoderma, leucorrhoea, itching, bronchitis, asthma, eye diseases, epileptic fits in children, kidney and urinary disorders, loss of appetite, burning sensation, dyspepsia, nutritional disorders, ulcer and rheumatism. Several studies are being carried towards its activities like analgesic, anti-inflammatory, antiulcer, hepatoprotective, antioxidant and helicobactericidal properties. In our study we have evaluated antacid activity of sariva (Anantmool) by using In-Vitro method, i.e. ANC (Acid Neutralizing Capacity). This evaluation was done by comparing the ANC of sariva macerated & powdered drug with water as blank & standard drug i.e. NaHCO3. Based on this In-Vitro experiment, we can conclude that, the macerated & powdered drug of sariva (Anantmool) evaluated in this study, varied in potency as measured in terms of their ANC. These results having ** i.e. P < 0.01 & Passed the normality test. However, the present study being in-vitro, the effects of antacid may vary In-Vitro; individual variations also contribute to the ultimate effectiveness of as antacid.        

scholarly journals In-vitro antiulcer activities of petal extract of Crocus sativus var. cashmerianus

2020 ◽  
pp. 6-8
Author(s):  
Vijender Kumar ◽  
Poonam Verma ◽  
Amarjit Kaur ◽  
Baljinder Singh
Keyword(s):  
Crocus Sativus ◽  
Acid Neutralizing Capacity ◽  
Inhibition Activity ◽  
Similar Dose ◽  
Neutralizing Capacity ◽  
Activity Method ◽  
Atpase Inhibition ◽  
Acid Neutralize ◽  
Capacity Method

Medicinal plants have been known for millennia as a rich source of traditional therapeutic agents for the prevention of diseases and ailments. The aim of the present study was performed to evaluate the antiulcer activities of hydro-alcoholic extracts of petals of Crocus sativus var. Cashmerianus by in-vitro methods viz. acid neutralizing capacity and H+/K+ - ATPase inhibition activity. In acid neutralizing capacity method, the petals extract significantly reduced acidity to 6.10 at a concentration of 1000 mg/ml as compared to 11.90 with standard 500 mg/ml of Aluminium hydroxide + Magnesium hydroxide combination. However, H+/K+ - ATPase inhibition activity method, petals extract showed maximum percentage inhibition of 70.31 % at the concentration 400µg/ml as compared to 73.82 % with a similar dose of standard Omeprazole. The IC 50 value of petals extract of C. sativus var. cashmerianus is shown 100 µg/ml in comparison with standard omeprazole of 82.5 µg/ml. The study reveals that the petals extract of C. sativus var. cashmerianus may contain compounds possessing acid neutralize and enzyme inhibition activities, thus it can be used as an alternative medicine for gastrointestinal disorders.

IMMUNOCHEMICAL EFFECTS OF INJECTION THERAPY WITH ALLERGENS BY CUSTOMARY AND INTENSIVE DOSAGE REGIMENS IN CHILDREN

PEDIATRICS ◽  
1972 ◽  
Vol 49 (4) ◽  
pp. 536-546
Author(s):  
C. D. May ◽  
M. Lyman ◽  
R. Alberto ◽  
N. Aduna
Keyword(s):  
Clinical Trials ◽  
Injection Therapy ◽  
Skin Tests ◽  
Protein Nitrogen ◽  
Blocking Antibody ◽  
Dosage Regimens ◽  
Neutralizing Capacity ◽  
Allergen Extracts ◽  
Frequent Measurement

Evaluation of dosage regimens for injection therapy with allergen extracts was undertaken by determination of immunochemical responses. Antigenic release of histamine was used as a means of measuring leukocyte sensitivity to allergens and antigen-neutralizing capacity of serum or "blocking" antibody. Customary dosage regimens providing 190,000 to 265,000 Protein Nitrogen Units of allergen in 2 years, and intensive dosage regimens providing these amounts or more in a few weeks were evaluated in 46 allergic children by frequent measurement of luekocyte sensitivity and antigen-neutralizing capacity of serum. Uninjected subjects were studied simultaneously. With 32 children receiving customary dosage regimens for injection of an allergen extract (Alternaria, ragweed, house dust), increases and decreases in leukocyte sensitivity in those children receiving injections did not differ significantly from others without injections. Modest increases in antigen-neutralizing capacity of serum occurred with injections. With 14 children receiving intensive dosage regimens for injection of the same allergens, much higher titers of antigen-neutralizing capacity in the serum could be achieved, but little net change in leukocyte sensitivity was observed, except for one case in which leukocytes became desensitized. In no case did intradermal skin tests with the allergens become negative, meaning the children were not desensitized. The dosage regimens used for injection of the allergens tested did not evoke immunochemical responses which encourage one to undertake extensive clinical trials.

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