scholarly journals Effect of 4-aminopyridine on potassium permeability of canine tracheal smooth muscle cell membrane.

1983 ◽  
Vol 33 (1) ◽  
pp. 201-208 ◽  
Author(s):  
Yuji IMAIZUMI ◽  
Minoru WATANABE
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Tracheal Smooth Muscle ◽  
Potassium Permeability ◽  
Tracheal Smooth Muscle Cell ◽  
Muscle Cell Membrane

Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets

2006 ◽  
Vol 291 (6) ◽  
pp. L1169-L1176 ◽  
Author(s):  
Candice D. Fike ◽  
Mark R. Kaplowitz ◽  
Yongmei Zhang ◽  
Jane A. Madden
Keyword(s):  
Pulmonary Hypertension ◽  
Smooth Muscle ◽  
Cell Membrane ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Chronic Hypoxia ◽  
Early Stage ◽  
Membrane Properties ◽  
Voltage Gated ◽  
Muscle Cell Membrane

Our purpose was to determine whether smooth muscle cell membrane properties are altered in small pulmonary arteries (SPA) of piglets at an early stage of pulmonary hypertension. Piglets were raised in either room air (control) or hypoxia for 3 days. A microelectrode technique was used to measure smooth muscle cell membrane potential ( Em) in cannulated, pressurized SPA (100- to 300-μm diameter). SPA responses to the voltage-gated K+ (KV) channel antagonist 4-aminopyridine (4-AP) and the KV1 family channel antagonist correolide were measured. Other SPA were used to assess amounts of KV1.2, KV1.5, and KV2.1 (immunoblot technique). Em was more positive in SPA of chronically hypoxic piglets than in SPA of comparable-age control piglets. The magnitude of constriction elicited by either 4-AP or correolide was diminished in SPA from hypoxic piglets. Abundances of KV1.2 were reduced, whereas abundances of both KV1.5 and KV2.1 were unaltered, in SPA from hypoxic piglets. At least partly because of reduced amounts of KV1.2, smooth muscle cell membrane properties are altered such that Em is depolarized and KV channel family function is impaired in SPA of piglets at an early stage of chronic hypoxia-induced pulmonary hypertension.

scholarly journals Receptor-Based Differences in Human Aortic Smooth Muscle Cell Membrane Stiffness

Hypertension ◽  
2001 ◽  
Vol 38 (5) ◽  
pp. 1158-1161 ◽  
Author(s):  
Hayden Huang ◽  
Roger D. Kamm ◽  
Peter T.C. So ◽  
Richard T. Lee
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Aortic Smooth Muscle Cell ◽  
Aortic Smooth Muscle ◽  
Membrane Stiffness ◽  
Muscle Cell Membrane

A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential

2014 ◽  
Vol 2 (24) ◽  
pp. 3809-3818 ◽  
Author(s):  
Zhiqiang Yu ◽  
Jie Li ◽  
Jinhang Zhu ◽  
Min Zhu ◽  
Feifei Jiang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Cell Membrane ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Membrane Potential ◽  
Trpv4 Channel ◽  
Muscle Cell Membrane

A synthetic K+-like channel mediates K+outward flow to regulate vascular smooth muscle cell membrane potential, blood vessel tone and blood pressure.

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