A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential

2014 ◽  
Vol 2 (24) ◽  
pp. 3809-3818 ◽  
Author(s):  
Zhiqiang Yu ◽  
Jie Li ◽  
Jinhang Zhu ◽  
Min Zhu ◽  
Feifei Jiang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Cell Membrane ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Membrane Potential ◽  
Trpv4 Channel ◽  
Muscle Cell Membrane

A synthetic K+-like channel mediates K+outward flow to regulate vascular smooth muscle cell membrane potential, blood vessel tone and blood pressure.

The role of vascular smooth muscle cell membrane-bound thrombomodulin in neointima formation

2019 ◽  
Vol 287 ◽  
pp. 54-63
Author(s):  
Kuan-Chieh Wang ◽  
Po-Sheng Chen ◽  
Ting-Hsing Chao ◽  
Chawn-Yau Luo ◽  
Hsing-Chun Chung ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Neointima Formation ◽  
Membrane Bound ◽  
Muscle Cell Membrane

scholarly journals Lipid-induced changes in vascular smooth muscle cell membrane fluidity are associated with DNA synthesis

1999 ◽  
Vol 32 (2-3) ◽  
pp. 101-105 ◽  
Author(s):  
Christopher Potten ◽  
Zbigniew Darzynkiewicz ◽  
Kohsuke Sasaki ◽  
A. Sachinidis ◽  
M. Carniel ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Vascular Smooth Muscle ◽  
Dna Synthesis ◽  
Smooth Muscle Cell ◽  
Membrane Fluidity ◽  
Muscle Cell ◽  
Cell Membrane Fluidity ◽  
Induced Changes ◽  
Muscle Cell Membrane

Unusual potassium channels mediate nonadrenergic noncholinergic nerve-mediated inhibition in opossum esophagus

1985 ◽  
Vol 63 (2) ◽  
pp. 107-112 ◽  
Author(s):  
J. Jury ◽  
L. P. Jager ◽  
E. E. Daniel
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Cell Membrane ◽  
Guinea Pig ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Membrane Resistance ◽  
Potassium Ion ◽  
Ion Permeability ◽  
Muscle Cell Membrane

Field stimulation of the circular muscle of the opossum esophagus produces a transient hyperpolarization (inhibitory junction potential, IJP) followed by an "off" depolarization. A similar nonadrenergic, noncholinergic (NANC) response in guinea pig taenia caecum has been shown to be due to an increase in the potassium ion permeability of the smooth muscle cell membrane. Double sucrose gap studies showed a decrease in resistance during the IJP, and a reversal at an estimated membrane potential of about −90 mV (4 mM K+). The reversal potential was dependent on the extracellular potassium concentration, shifting to −75 mV when the potassium in the superfusion medium was increased to 10 mM. The IJP in the opossum esophageal circular smooth muscle is therefore like the IJP of the guinea pig taenia caecum in that it is probably due to a selective increase in potassium ion permeability. Potassium conductance blocking agents, tetraethylammonium chloride (TEA, 20 mM) and 4-aminopyridine (4-AP, 5 mM) both caused a depolarization of the smooth muscle cell membrane, but TEA increased the membrane resistance, whereas 4-AP did not affect the membrane conductance in a consistent way. A decrease in IJP amplitude owing to these agents was not apparent. Apamin (10 μM) did not affect the membrane potential, the membrane resistance, or the IJP. Quinine (0.1 mM) produced effects quantitatively similar to those of TEA. Quinine (1 mM) did abolish the IJP, however, this was likely due to a blockade of impulse transmission of the intramural nerves. These results suggest that the receptor-operated channels opened by the NANC-nerve mediator in this tissue are unusual in that they are different from those functioning to maintain the resting membrane potential and they differ from those involved in the IJP in the guinea pig taenia caecum.

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