scholarly journals Inhibition of homologous passive cutaneous anaphylaxis (PCA) by disodium cromoglycate-related compounds.

1980 ◽  
Vol 30 (4) ◽  
pp. 437-447 ◽  
Author(s):  
Akihide KODA ◽  
Kenichi SAKAMOTO ◽  
Yukiyoshi YANAGIHARA
Keyword(s):  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate ◽  
Related Compounds

The effect of predosage with disodium cromoglycate (DSCG) on the dose-related inhibition of rat passive cutaneous anaphylaxis by DSCG

Life Sciences ◽  
1975 ◽  
Vol 17 (5) ◽  
pp. 793-802 ◽  
Author(s):  
Patricia A. Riley ◽  
Philip Sheard ◽  
Alan J. Clarke ◽  
T.SamuelC. Orr
Keyword(s):  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate

The Pharmacology of Passive Cutaneous Anaphylaxis in the Calf

1972 ◽  
Vol 50 (3) ◽  
pp. 255-262 ◽  
Author(s):  
P. W. Wells ◽  
P. Eyre
Keyword(s):  
Latent Period ◽  
Horse Serum ◽  
Inhibitory Effect ◽  
Threshold Dose ◽  
Antigen Challenge ◽  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate ◽  
Diethylcarbamazine Citrate ◽  
Anaphylactic Response ◽  
Passive Cutaneous Anaphylaxis Reaction

The effects of mepyramine maleate, sodium meclofenamate, methysergide bimaleate, diethylcarbamazine citrate, and disodium cromoglycate on bovine cutaneous anaphylactic reactions and responses to intradermal injections of histamine, 5-hydroxytryptamine, and bradykinin were studied. Calves sensitized by immunization with horse serum in Freund's complete adjuvant were bled to obtain skin-sensitizing serum which was used in passive cutaneous anaphylaxis (P.C.A.) tests. A latent period of 72 h was allowed between intradermal injections of sera and antigen challenge. Mepyramine maleate (10 mg/kg) selectively inhibited responses to histamine and raised the threshold dose of antibody required to elicit a response. Disodium cromoglycate (DSCG, 10 mg/kg) given intravenously 30 min or immediately prior to challenge had no significant effect either on the responses to drugs or on the passive cutaneous anaphylaxis reaction. Diethylcarbamazine (DECC, 20 mg/kg) administered immediately prior to challenge significantly inhibited the cutaneous anaphylactic response and when DSCG was given simultaneously with DECC, this inhibitory effect was apparently augmented. Methysergide (1 mg/kg) and sodium meclofenamate (2 mg/kg) were ineffective in suppressing P.C.A. It is concluded that histamine and a slow-reacting substance (SRS-A) are involved in the mediation of bovine cutaneous anaphylaxis and that kinins may contribute, while 5-hydroxytryptamine would appear unimportant.

Synthesis and structure-activity relations of disodium cromoglycate and some related compounds

1972 ◽  
Vol 15 (6) ◽  
pp. 583-589 ◽  
Author(s):  
H. Cairns ◽  
C. Fitzmaurice ◽  
D. Hunter ◽  
P. B. Johnson ◽  
J. King ◽  
...  
Keyword(s):  
Disodium Cromoglycate ◽  
Structure Activity ◽  
Structure Activity Relations ◽  
Related Compounds

Zebrafish models for hallucinogenic-related compounds

2013 ◽  
Author(s):  
A. V. Kalueff ◽  
A. M. Stewart ◽  
V. Gjeloshi ◽  
D. Kondaveeti ◽  
N. Neelkantan ◽  
...  
Keyword(s):  
Related Compounds
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