Disodium Cromoglycate and Inhibition of Passive Cutaneous Anaphylaxis

1971 ◽  
Vol 41 (1) ◽  
pp. 163-165 ◽  
Author(s):  
S.I. Ankier
Keyword(s):  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate

The effect of predosage with disodium cromoglycate (DSCG) on the dose-related inhibition of rat passive cutaneous anaphylaxis by DSCG

Life Sciences ◽  
1975 ◽  
Vol 17 (5) ◽  
pp. 793-802 ◽  
Author(s):  
Patricia A. Riley ◽  
Philip Sheard ◽  
Alan J. Clarke ◽  
T.SamuelC. Orr
Keyword(s):  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate

The Pharmacology of Passive Cutaneous Anaphylaxis in the Calf

1972 ◽  
Vol 50 (3) ◽  
pp. 255-262 ◽  
Author(s):  
P. W. Wells ◽  
P. Eyre
Keyword(s):  
Latent Period ◽  
Horse Serum ◽  
Inhibitory Effect ◽  
Threshold Dose ◽  
Antigen Challenge ◽  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate ◽  
Diethylcarbamazine Citrate ◽  
Anaphylactic Response ◽  
Passive Cutaneous Anaphylaxis Reaction

The effects of mepyramine maleate, sodium meclofenamate, methysergide bimaleate, diethylcarbamazine citrate, and disodium cromoglycate on bovine cutaneous anaphylactic reactions and responses to intradermal injections of histamine, 5-hydroxytryptamine, and bradykinin were studied. Calves sensitized by immunization with horse serum in Freund's complete adjuvant were bled to obtain skin-sensitizing serum which was used in passive cutaneous anaphylaxis (P.C.A.) tests. A latent period of 72 h was allowed between intradermal injections of sera and antigen challenge. Mepyramine maleate (10 mg/kg) selectively inhibited responses to histamine and raised the threshold dose of antibody required to elicit a response. Disodium cromoglycate (DSCG, 10 mg/kg) given intravenously 30 min or immediately prior to challenge had no significant effect either on the responses to drugs or on the passive cutaneous anaphylaxis reaction. Diethylcarbamazine (DECC, 20 mg/kg) administered immediately prior to challenge significantly inhibited the cutaneous anaphylactic response and when DSCG was given simultaneously with DECC, this inhibitory effect was apparently augmented. Methysergide (1 mg/kg) and sodium meclofenamate (2 mg/kg) were ineffective in suppressing P.C.A. It is concluded that histamine and a slow-reacting substance (SRS-A) are involved in the mediation of bovine cutaneous anaphylaxis and that kinins may contribute, while 5-hydroxytryptamine would appear unimportant.

scholarly journals Time Dependent Lyotropic Chromonic Textures in Microfluidic Confinements

Crystals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 35 ◽  
Author(s):  
Anshul Sharma ◽  
Irvine Lian Hao Ong ◽  
Anupam Sengupta
Keyword(s):  
Phase Transition ◽  
Aspect Ratio ◽  
Temporal Dynamics ◽  
Initial Conditions ◽  
Flow Behavior ◽  
Medical Diagnostics ◽  
Time Dependent ◽  
Disodium Cromoglycate ◽  
M Phase ◽  
Static Conditions

Nematic and columnar phases of lyotropic chromonic liquid crystals (LCLCs) have been long studied for their fundamental and applied prospects in material science and medical diagnostics. LCLC phases represent different self-assembled states of disc-shaped molecules, held together by noncovalent interactions that lead to highly sensitive concentration and temperature dependent properties. Yet, microscale insights into confined LCLCs, specifically in the context of confinement geometry and surface properties, are lacking. Here, we report the emergence of time dependent textures in static disodium cromoglycate (DSCG) solutions, confined in PDMS-based microfluidic devices. We use a combination of soft lithography, surface characterization, and polarized optical imaging to generate and analyze the confinement-induced LCLC textures and demonstrate that over time, herringbone and spherulite textures emerge due to spontaneous nematic (N) to columnar M-phase transition, propagating from the LCLC-PDMS interface into the LCLC bulk. By varying the confinement geometry, anchoring conditions, and the initial DSCG concentration, we can systematically tune the temporal dynamics of the N- to M-phase transition and textural behavior of the confined LCLC. Overall, the time taken to change from nematic to the characteristic M-phase textures decreased as the confinement aspect ratio (width/depth) increased. For a given aspect ratio, the transition to the M-phase was generally faster in degenerate planar confinements, relative to the transition in homeotropic confinements. Since the static molecular states register the initial conditions for LC flows, the time dependent textures reported here suggest that the surface and confinement effects—even under static conditions—could be central in understanding the flow behavior of LCLCs and the associated transport properties of this versatile material.

Effect of Amino Acids on the Dispersion of Disodium Cromoglycate Powders

2005 ◽  
Vol 94 (10) ◽  
pp. 2289-2300 ◽  
Author(s):  
Nora Y.K. Chew ◽  
Boris Y. Shekunov ◽  
Henry H.Y. Tong ◽  
Albert H.L. Chow ◽  
Charles Savage ◽  
...  
Keyword(s):  
Amino Acids ◽  
Disodium Cromoglycate

scholarly journals Clinical trial of disodium cromoglycate in treatment of asthma in children.

BMJ ◽  
1968 ◽  
Vol 2 (5601) ◽  
pp. 340-344 ◽  
Author(s):  
J. M. Smith ◽  
G. F. Devey
Keyword(s):  
Clinical Trial ◽  
Disodium Cromoglycate ◽  
Asthma In Children
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