scholarly journals A correlation between the species differences in anti-inflammatory activity of AD-1590, a non-steroidal anti-inflammatory drug, and its plasma level.

1988 ◽  
Vol 91 (6) ◽  
pp. 393-399
Author(s):  
Hideo NAKAMURA ◽  
Yasuhiro SETO ◽  
Satoru MOTOYOSHI ◽  
Yuichi YOKOYAMA ◽  
Toshiaki KADOKAWA
Keyword(s):  
Plasma Level ◽  
Species Differences ◽  
Inflammatory Activity ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Inhibition of Formalin Induced Paw Edema in Rats by Various Fractions/Extracts of Bryophyllum pinnatum

2019 ◽  
Vol 7 (2) ◽  
pp. 63-66
Author(s):  
R. K. Gupta ◽  
M. Lohani ◽  
R. Vishwakarma
Keyword(s):  
Rat Model ◽  
Leaf Extract ◽  
Marked Decrease ◽  
Inflammatory Diseases ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Standard Drug ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Bryophyllum Pinnatum

Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed as ant-inflammatory drug after further studies.

scholarly journals Non-Steroid Inflammation (Nsaid) Drug Selling Profile Based On Self-Medication Service at Mida Farma I Drugstore Gresik

2021 ◽  
Vol 1 (1) ◽  
pp. 24-29
Author(s):  
Helmi Hanifah ◽  
Pemta Tiadeka ◽  
Riskha Aulia
Keyword(s):  
Side Effects ◽  
Plasma Level ◽  
Data Collection ◽  
Maximum Plasma ◽  
Observational Method ◽  
Self Medication ◽  
Inflammatory Drug ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory

This study aims to determine the profile of self-medication sales of non-steroidal anti-inflammatory drugs at Mida Farma I Drugstore Gresik. It is conducted by using the observational method with data collection and observation on the Non-Steroid Anti-Inflammatory Drug (NSAID) stock cards in February 2020 at Mida Farma I Drugstore Gresik. The results show that the highest sales profile is the non-selective group of 87.68%, then the second is the COX-2 selective group of 12.32%. The most sold drug is ibuprofen of 20% and the lowest sold one is Aspirin of 14%. The pharmacokinetics of ibuprofen are it absorbs very quickly through the stomach; has a maximum plasma level that has reached 1 to 2 hours; and has low side effects

scholarly journals In Vivo Anti-inflammatory Activity of Some Naturally Occurring O- and N-Prenyl Secondary Metabolites

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900
Author(s):  
Francesco Epifano ◽  
Salvatore Genovese ◽  
Serena Fiorito ◽  
Roberto della Loggia ◽  
Aurelia Tubaro ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Plant Origin ◽  
Inflammatory Drug ◽  
Naturally Occurring ◽  
Croton Oil ◽  
Anti Inflammatory

A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 +0.56 μmol/cm2) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 μmol/cm2).

Benoxaprofen (opren)

1981 ◽  
Vol 19 (24) ◽  
pp. 95-96
Keyword(s):  
Mode Of Action ◽  
Inflammatory Process ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Animal Tests

Benoxaprofen (Opren - Dista) is a non-steroidal anti-inflammatory drug (NSAID) with a novel mode of action. Other NSAIDs inhibit the formation of prostaglandins which are important in acute inflammation. Benoxaprofen has little such activity, but modifies leucocyte function, especially the migration of monocytes which perpetuate the inflammatory process.1 The significance of this mode of action is unclear. In the usual animal tests of anti-inflammatory activity benoxaprofen is as effective as phenylbutazone.2

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