scholarly journals Pharmacological studies of a liapse GA-56 produced by Pseudomonas sp. IV. Chronic toxicity of GA-56.

1974 ◽  
Vol 70 (1) ◽  
pp. 89-105
Author(s):  
Shunkichi TAMURA ◽  
Shigeru NOZAKI
Keyword(s):  
Chronic Toxicity ◽  
Pseudomonas Sp ◽  
Pharmacological Studies

scholarly journals Pharmacological studies of a lipase GA-56 produced by Pseudomonas sp.

1973 ◽  
Vol 69 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Shunkichi TAMURA ◽  
Shigeru NOZAKI
Keyword(s):  
Pseudomonas Sp ◽  
Pharmacological Studies

PHARMACOLOGICAL STUDIES ON NEW SYNTHETIC ANTITUSSIVE AGENTS

1958 ◽  
Vol 36 (1) ◽  
pp. 475-481
Author(s):  
C. I. Chappel ◽  
M.-G. P. Stegen ◽  
G. A. Grant
Keyword(s):  
Clinical Trial ◽  
Chronic Toxicity ◽  
Alkyl Esters ◽  
Antispasmodic Activity ◽  
Pharmacological Studies ◽  
Local Anaesthetic Action ◽  
Antitussive Activity ◽  
Antitussive Agents ◽  
Anaesthetic Action ◽  
Central Depressant

In an attempt to overcome the inherent disadvantage of narcotic antitussive therapy, three basic alkoxy-alkyl esters of phenothiazine-10-carboxylic acid were synthesized and tested for pharmacological activity. These compounds possessed antitussive activity in the cat in the range of activity of codeine. Dimethyl-amino-ethoxy-ethyl phenothiazine-10-carboxylate was chosen, on the basis of strong antitussive activity coupled with low acute toxicity and low antispasmodic activity, for chronic toxicity studies and clinical trial. This compound is devoid of central depressant or analgesic properties and possesses a moderate local anaesthetic action.

scholarly journals Pharmacological studies of a lipase GA-56 produced by Pseudomonas sp.

1973 ◽  
Vol 69 (1) ◽  
pp. 177-189
Author(s):  
Shunkichi TAMURA ◽  
Shoji TSUTSUMI ◽  
Shigeru NOZAKI
Keyword(s):  
Pseudomonas Sp ◽  
Pharmacological Studies

PHARMACOLOGICAL STUDIES ON NEW SYNTHETIC ANTITUSSIVE AGENTS

1958 ◽  
Vol 36 (5) ◽  
pp. 475-481 ◽  
Author(s):  
C. I. Chappel ◽  
M.-G. P. Stegen ◽  
G. A. Grant
Keyword(s):  
Clinical Trial ◽  
Chronic Toxicity ◽  
Alkyl Esters ◽  
Antispasmodic Activity ◽  
Pharmacological Studies ◽  
Local Anaesthetic Action ◽  
Antitussive Activity ◽  
Antitussive Agents ◽  
Anaesthetic Action ◽  
Central Depressant

In an attempt to overcome the inherent disadvantage of narcotic antitussive therapy, three basic alkoxy-alkyl esters of phenothiazine-10-carboxylic acid were synthesized and tested for pharmacological activity. These compounds possessed antitussive activity in the cat in the range of activity of codeine. Dimethyl-amino-ethoxy-ethyl phenothiazine-10-carboxylate was chosen, on the basis of strong antitussive activity coupled with low acute toxicity and low antispasmodic activity, for chronic toxicity studies and clinical trial. This compound is devoid of central depressant or analgesic properties and possesses a moderate local anaesthetic action.

Phytochemical and pharmacological studies of Crotalaria madurensis leaves

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SHM Hala ◽  
SAM Mohamed ◽  
TI Magada ◽  
SA El Batran ◽  
DE Omayma
Keyword(s):  
Pharmacological Studies

Phytochemical and pharmacological studies on commercial teas

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
HC Rodda ◽  
FKE Rubra ◽  
B Ramya
Keyword(s):  
Pharmacological Studies

Mechanism of the Antiplatelet Action of Dipyridamole in Whole Blood: Modulation of Adenosine Concentration and Activity

1986 ◽  
Vol 55 (01) ◽  
pp. 012-018 ◽  
Author(s):  
Paolo Gresele ◽  
Jef Arnout ◽  
Hans Deckmyn ◽  
Jos Vermylen
Keyword(s):  
Platelet Aggregation ◽  
Adenosine Receptor ◽  
Whole Blood ◽  
Blood Cells ◽  
Inhibitory Action ◽  
Phosphodiesterase Inhibitor ◽  
Inhibitory Effect ◽  
Adenosine Concentration ◽  
Pharmacological Studies

SummaryDipyridamole inhibits platelet aggregation in whole blood at lower concentrations than in plasma. The blood cells responsible for increased effectiveness in blood are the erythrocytes. Using the impedance aggregometer we have carried out a series of pharmacological studies in vitro to elucidate the mechanism of action of dipyridamole in whole blood. Adenosine deaminase, an enzyme breaking down adenosine, reverses the inhibitory action of dipyridamole. Two different adenosine receptor antagonists, 5’-deoxy-5’-methylthioadenosine and theophylline, also partially neutralize the activity of dipyridamole in blood. Enprofylline, a phosphodiesterase inhibitor with almost no adenosine receptor antagonistic properties, potentiates the inhibition of platelet aggregation by dipyridamole. An inhibitory effect similar to that of dipyridamole can be obtained combining a pure adenosine uptake inhibitor (RE 102 BS) with a pure phosphodiesterase inhibitor (MX-MB 82 or enprofylline). Mixing the blood during preincubation with dipyridamole increases the degree of inhibition. Lowering the haematocrit slightly reduces the effectiveness.Although we did not carry out direct measurements of adenosine levels, the results of our pharmacological studies clearly show that dipyridamole inhibits platelet aggregation in whole blood by blocking the reuptake of adenosine formed from precursors released by red blood cells following microtrauma. Its slight phosphodiesterase inhibitory action potentiates the effects of adenosine on platelets.

Sign in / Sign up

Export Citation Format

Share Document