scholarly journals Liberation of histamine-like substances by colistin derivatives

1970 ◽  
Vol 66 (2) ◽  
pp. 284-291
Author(s):  
Tomonori MATUMOTO
Keyword(s):  
Liberation Of Histamine

Liberation of Histamine and Heparin by Peptone from the Isolated Dog's Liver.

1947 ◽  
Vol 64 (2) ◽  
pp. 141-146 ◽  
Author(s):  
M. Rocha ◽  
E. Silva ◽  
A. Evelyn Scroggie ◽  
E. Fidlar ◽  
L. B. Jaques
Keyword(s):  
Liberation Of Histamine

scholarly journals CYTOLOGICAL AND PHARMACOLOGICAL OBSERVATIONS ON THE RELEASE OF HISTAMINE BY MAST CELLS

1954 ◽  
Vol 100 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Don W. Fawcett
Keyword(s):  
Mast Cells ◽  
Peritoneal Fluid ◽  
Appreciable Amount ◽  
Fluid Solution ◽  
Tyrode Solution ◽  
Morphological Effect ◽  
Liberation Of Histamine ◽  
To Come ◽  
Histamine Liberator ◽  
Extensive Release

Experimental solutions known to affect mast cells or to cause liberation of histamine from the tissue were introduced into the peritoneal cavity of rats. Samples of the peritoneal fluid were withdrawn at intervals afterward and assayed for histamine and the condition of the mast cells was subsequently ascertained by microscopic examination of stained spreads of the mesenteries. Intraperitoneal injection of distilled water caused osmotic disruption of the mast cells and the appearance of an appreciable amount of histamine in the peritoneal fluid. Injection of Tyrode solution alone was not particularly damaging to the mast cells and little or no histamine was released. Injection of Tyrode solution containing compound 48/80 resulted in extensive release of granules from mast cells and the appearance of large amounts of histamine in the fluid. Solution of 48/80 failed however to cause histamine release when injected into rats whose subserosal mast cells had previously been destroyed. A series of increasing doses of compound 48/80 had a graded morphological effect upon mast cells and resulted in a graded increase in the amount of histamine that appeared in the peritoneal fluid. It is unlikely therefore that this compound acts by simply lysing the plasma membrane. It is concluded that mast cells in the rat are extraordinarily rich in histamine which is liberated under conditions which cause mast cells to release their granules. The histamine set free by the potent histamine liberator, compound 48/80, appears to come principally from the tissue mast cells.

Liberation of Histamine by Trypsin

1940 ◽  
Vol 43 (2) ◽  
pp. 360-361 ◽  
Author(s):  
M. R. de Arellano ◽  
A. H. Lawton ◽  
C. A. Dragstedt
Keyword(s):  
Liberation Of Histamine

scholarly journals The liberation of histamine by certain organic bases

1949 ◽  
Vol 109 (1-2) ◽  
pp. 190-219 ◽  
Author(s):  
F. C. Macintosh ◽  
W. D. M. Paton
Keyword(s):  
Organic Bases ◽  
Liberation Of Histamine

scholarly journals TISSUE REACTIONS TO ANAPHYLACTIC AND ANAPHYLACTOID STIMULI; PROTEOLYSIS AND RELEASE OF HISTAMINE AND HEPARIN

1955 ◽  
Vol 101 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Georges Ungar ◽  
Evelyn Damgaard
Keyword(s):  
Intact Animal ◽  
Specific Antigen ◽  
Present Knowledge ◽  
Tween 20 ◽  
Protein Breakdown ◽  
Tissue Slices ◽  
Normal Tissues ◽  
Liberation Of Histamine ◽  
Tissue Reactions ◽  
Causal Event

Addition of the specific antigen to slices of liver or lung taken from sensitized guinea pigs, or the addition of anaphylactoid agents (tween 20, octadecylamine, morphine, and 48/80) to tissue slices from normal animals, or the perfusion of lung with these agents, has been shown to cause protein breakdown and liberation of histamine and heparin. The dose correlation between these phenomena raises the question of which is the causal event. Suppression of histamine and heparin release by inhibition of proteolysis suggests that the latter is the more fundamental reaction, but the problem probably can not be decided on the basis of present knowledge. Tissue proteolysis induced by the agents investigated in this work results from the action of a protease present in normal tissues as an inactive precursor. Conversion of the proenzyme requires the intervention of a kinase. The tissue kinase seems to be different from the serum kinase which has been shown to be related to complement. Serum kinase, however, also acts on tissue proenzyme and probably plays an important role in tissue reactions as elicited in the intact animal.

scholarly journals Liberation of histamine by the heart muscle

1936 ◽  
Vol 86 (4) ◽  
pp. 431-451 ◽  
Author(s):  
G. V. Anrep ◽  
G. S. Barsoum ◽  
M. Talaat
Keyword(s):  
Heart Muscle ◽  
Liberation Of Histamine
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