scholarly journals Pharmacological profiles and clinical effects of recombinant human thyrotropin alfa (Thyrogen® Intramuscular Injection 0.9 mg)

2009 ◽  
Vol 134 (1) ◽  
pp. 28-34
Author(s):  
Hiroshi Kishida
Keyword(s):  
Intramuscular Injection ◽  
Clinical Effects ◽  
Recombinant Human Thyrotropin ◽  
Pharmacological Profiles

scholarly journals Pharmacological profiles and clinical effects of lapatinib tosilate (Tykerb®)

2010 ◽  
Vol 136 (3) ◽  
pp. 175-184
Author(s):  
Hiroyuki Arai ◽  
Mami Yamaki ◽  
Yuichiro Nishimura
Keyword(s):  
Clinical Effects ◽  
Pharmacological Profiles

scholarly journals Pharmacological profiles and clinical effects of amenamevir tablet as treatments for herpes zoster

2019 ◽  
Vol 153 (1) ◽  
pp. 35-43
Author(s):  
Hiromi Maeda ◽  
Hideki Nakamura ◽  
Yoshinobu Kikukawa
Keyword(s):  
Herpes Zoster ◽  
Clinical Effects ◽  
Pharmacological Profiles

scholarly journals Physiological and Clinical Responses in Pigs in Relation to Plasma Concentrations during Anesthesia with Dexmedetomidine, Tiletamine, Zolazepam, and Butorphanol

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1482
Author(s):  
Anneli Rydén ◽  
Marianne Jensen-Waern ◽  
Görel Nyman ◽  
Lena Olsén
Keyword(s):  
Intramuscular Injection ◽  
Plasma Concentrations ◽  
Spontaneous Respiration ◽  
Pharmacokinetic Parameters ◽  
Repeated Injection ◽  
Clinical Effects ◽  
Short Term ◽  
Drug Plasma Concentrations ◽  
Drug Plasma ◽  
Clinical Responses

Reliable protocols for short-term anesthetics are essential to safeguard animal welfare during medical investigations. The aim of the study was to assess the adequacy and reliability of an anesthetic protocol and to evaluate physiological and clinical responses, in relation to the drug plasma concentrations, for pigs undergoing short-term anesthesia. A second aim was to see whether an intravenous dosage could prolong the anesthesia. The anesthesia was induced by an intramuscular injection of dexmedetomidine, tiletamine zolazepam, and butorphanol in 12 pigs. In six of the pigs, a repeated injection intravenously of one-third of the initial dose was given after one hour. The physiological and clinical effects from induction to recovery were examined. Plasma concentrations of the drugs were analyzed and pharmacokinetic parameters were calculated. Each drug’s absorption and time to maximal concentration were rapid. All pigs were able to maintain spontaneous respiration. The route of administration did not alter the half-life of the drug. The results suggest that intramuscular administration of the four-drug combination provides up to two hours of anesthesia with stable physiological parameters and an acceptable level of analgesia while maintaining spontaneous respiration. A repeated intravenous injection may be used to extend the time of anesthesia by 30 min.

scholarly journals Pharmacological profiles and clinical effects of blonanserin (Lonasen®) on schizophrenia

2008 ◽  
Vol 132 (6) ◽  
pp. 351-360 ◽  
Author(s):  
Tadashi Ishibashi ◽  
Hiroyuki Nishikawa ◽  
Teruaki Une ◽  
Hiroshi Nakamura
Keyword(s):  
Clinical Effects ◽  
Pharmacological Profiles

scholarly journals Pharmacological profiles and clinical effects of benzoyl peroxide gel as treatments for acne vulgaris

2015 ◽  
Vol 146 (4) ◽  
pp. 225-232 ◽  
Author(s):  
Hiroshi Morimoto ◽  
Yoshinobu Kikukawa ◽  
Naofumi Murakami
Keyword(s):  
Benzoyl Peroxide ◽  
Acne Vulgaris ◽  
Clinical Effects ◽  
Pharmacological Profiles
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