scholarly journals Pharmacological profiles and clinical effects of oral sustained release beraprost sodium (Careload ®LA Tablets 60μg, Berasus®LA Tablets 60μg)

2009 ◽  
Vol 133 (2) ◽  
pp. 101-111 ◽  
Author(s):  
Hajimu Kurumatani
Keyword(s):  
Sustained Release ◽  
Clinical Effects ◽  
Beraprost Sodium ◽  
Pharmacological Profiles

scholarly journals Pharmacological profiles and clinical effects of lapatinib tosilate (Tykerb®)

2010 ◽  
Vol 136 (3) ◽  
pp. 175-184
Author(s):  
Hiroyuki Arai ◽  
Mami Yamaki ◽  
Yuichiro Nishimura
Keyword(s):  
Clinical Effects ◽  
Pharmacological Profiles

scholarly journals A prospective randomized comparative study of the efficacy of sustained release vaginal insert versus intracervical gel in primigravidae at term pregnancy

2020 ◽  
Vol 9 (4) ◽  
pp. 1532
Author(s):  
Thejaswi R. Thupakula ◽  
Bela Makhija ◽  
Arpana Haritwal
Keyword(s):  
Sustained Release ◽  
Dropout Rate ◽  
Cold Chain ◽  
Clinical Effects ◽  
Term Pregnancy ◽  
Duration Of Action ◽  
Successful Induction ◽  
Group A ◽  
Consecutive Term ◽  
Group B

vBackground: Induction of labour is the intentional initiation of labour before spontaneous onset for the purpose of delivery of fetoplacental unit. Failure of induction is responsible for increased incidence of caesarean delivery. This study performed to assess and compare the clinical effects of sustained release vaginal insert versus intracervical gel in primiparous women with term pregnancy in terms of improvement of Bishop’s score, Induction delivery interval, incidence of hyperstimulation, maternal and neonatal outcomes.Methods: A total 100 consecutive term pregnant women who underwent labor induction for fetal or maternal indications were divided randomly into two groups. Group A - sustained release Vaginal insert and Group B - Intracervical gel. Informed consent was taken from each patient.Results: Statistically significant increase in final Bishop’s score (p=0.008) and hyperstimulation (p=0.04) was seen in Vaginal insert group as compared to Intracervical gel group, while there were no statistically significant differences in maternal outcomes, neonatal outcomes and need for oxytocin augmentation in both groups.Conclusions: In this study we found that insert did not improve the induction delivery interval or rate of successful induction, nor did it have any advantage in terms of neonatal outcome although it did improve the Bishops score – Its advantage was in terms of single application, few prevaginal examinations, longer duration of action and immediate retrieval in case of hyperstimulation. Its main drawback remained the maintenance of cold chain without which its efficacy decreases. Another significant observation was the dropout rate of insert (16%).

scholarly journals Pharmacological profiles and clinical effects of amenamevir tablet as treatments for herpes zoster

2019 ◽  
Vol 153 (1) ◽  
pp. 35-43
Author(s):  
Hiromi Maeda ◽  
Hideki Nakamura ◽  
Yoshinobu Kikukawa
Keyword(s):  
Herpes Zoster ◽  
Clinical Effects ◽  
Pharmacological Profiles

scholarly journals Efficacy of Chlorhexidine Varnish in Patients Undergoing Multibracket Fixed Orthodontic Treatment: A Controlled Clinical Study

2018 ◽  
Vol 11 (2) ◽  
pp. 945-950 ◽  
Author(s):  
Arjun Sehgal ◽  
Siddarth Shetty ◽  
Ashith M. V ◽  
Nidhin Philip Jose ◽  
Utkarsh Mangal
Keyword(s):  
Clinical Study ◽  
Sustained Release ◽  
Orthodontic Treatment ◽  
Bacterial Count ◽  
Clinical Effects ◽  
Duration Of Action ◽  
Gingival Health ◽  
Prophylactic Measures ◽  
Controlled Clinical Study

During fixed orthodontic treatment, maintenance of a good gingival health is challenging. This necessitates use of prophylactic measures, such as use of fluoridated tooth pastes and application of varnish. Use of chlorhexidine (CHX) varnish, is believed to reduce the bacterial count and have a longer duration of action, by virtue of sustained release. Therefore, the aim of the present study is to assess the clinical effects of chlorhexidine varnish (Cervitec plus) on plaque accumulation and gingival health during multibracketorthodontic treatment.

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