scholarly journals Pharmacological Effects of .SIGMA.-Receptor Ligands. Functional characterization of a sigma receptor and its gene expression by haloperidol.

1999 ◽  
Vol 114 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Yoshihiro NAKATA ◽  
Atsuko INOUE ◽  
Sayori SUGITA
Keyword(s):  
Gene Expression ◽  
Functional Characterization ◽  
Sigma Receptor ◽  
Pharmacological Effects ◽  
Receptor Ligands ◽  
Sigma Receptor Ligands ◽  
Its Gene

Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands

2019 ◽  
Vol 174 ◽  
pp. 226-235 ◽  
Author(s):  
Giuseppe Romeo ◽  
Orazio Prezzavento ◽  
Sebastiano Intagliata ◽  
Valeria Pittalà ◽  
Maria N. Modica ◽  
...  
Keyword(s):  
Sigma Receptor ◽  
Receptor Ligands ◽  
Sigma Receptor Ligands ◽  
In Vivo Characterization

scholarly journals HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

1999 ◽  
Vol 19 (11) ◽  
pp. 7816-7827 ◽  
Author(s):  
Audrey H. Wang ◽  
Nicholas R. Bertos ◽  
Marko Vezmar ◽  
Nadine Pelletier ◽  
Milena Crosato ◽  
...  
Keyword(s):  
Gene Expression ◽  
Histone Deacetylase ◽  
Sequence Similarity ◽  
Functional Characterization ◽  
Small Region ◽  
Chromosome Band ◽  
Terminal Domain ◽  
Its Gene ◽  
Repression Domain

ABSTRACT Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similarity to the deacetylase domain of yeast HDA1. HDAC4 is expressed in various adult human tissues, and its gene is located at chromosome band 2q37. HDAC4 possesses histone deacetylase activity intrinsic to its C-terminal domain. When tethered to a promoter, HDAC4 represses transcription through two independent repression domains, with repression domain 1 consisting of the N-terminal 208 residues and repression domain 2 containing the deacetylase domain. Through a small region located at its N-terminal domain, HDAC4 interacts with the MADS-box transcription factor MEF2C. Furthermore, HDAC4 and MEF2C individually upregulate but together downmodulate c-jun promoter activity. These results suggest that HDAC4 interacts with transcription factors such as MEF2C to negatively regulate gene expression.

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