scholarly journals Pharmacological Effects of .SIGMA.-Receptor Ligands. Possible role of .SIGMA.-receptors in the regulation of cough reflex, gastrointestinal and retinal function.

1999 ◽  
Vol 114 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Junzo KAMEI
Keyword(s):  
Retinal Function ◽  
Sigma Receptor ◽  
Sigma Receptors ◽  
Pharmacological Effects ◽  
Receptor Ligands ◽  
Cough Reflex ◽  
Sigma Receptor Ligands

scholarly journals Highly Specific Sigma Receptor Ligands Exhibit Anti-viral Properties in SARS-CoV-2 Infected Cells

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1514
Author(s):  
David A. Ostrov ◽  
Andrew P. Bluhm ◽  
Danmeng Li ◽  
Juveriya Qamar Khan ◽  
Megha Rohamare ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Sigma Receptor ◽  
Sigma Receptors ◽  
Genome Replication ◽  
Receptor Ligands ◽  
Sigma 1 Receptor ◽  
Binding Characteristics ◽  
Sigma Receptor Ligands ◽  
Prevention And Treatment ◽  
Sigma 1

(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2 proteins present in the replication complex. (2) Methods: In this work, highly specific sigma receptor ligands were investigated for their ability to inhibit both SARS-CoV-2 genome replication and virus induced cellular toxicity. This study found antiviral activity associated with agonism of the sigma-1 receptor (e.g., SA4503), ligation of the sigma-2 receptor (e.g., CM398), and a combination of the two pathways (e.g., AZ66). (3) Results: Intermolecular contacts between these ligands and sigma receptors were identified by structural modeling. (4) Conclusions: Sigma receptor ligands and drugs with off-target sigma receptor binding characteristics were effective at inhibiting SARS-CoV-2 infection in primate and human cells, representing a potential therapeutic avenue for COVID-19 prevention and treatment.

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