scholarly journals Circadian Variation of the Onset of Acute Myocardial Infarction in the Osaka Area, 1998-1999

2001 ◽  
Vol 65 (7) ◽  
pp. 617-620 ◽  
Author(s):  
Kunihiro Kinjo ◽  
Hideyuki Sato ◽  
Hiroshi Sato ◽  
Issei Shiotani ◽  
Toshiya Kurotobi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Circadian Variation

Circadian variation in the occurrence of tako-tsubo cardiomyopathy: Comparison with acute myocardial infarction

2007 ◽  
Vol 115 (2) ◽  
pp. 270-271 ◽  
Author(s):  
Satoshi Kurisu ◽  
Ichiro Inoue ◽  
Takuji Kawagoe ◽  
Masaharu Ishihara ◽  
Yuji Shimatani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Circadian Variation ◽  
Tako Tsubo Cardiomyopathy

scholarly journals Pattern of serum cardiac troponin-I in symptomatic acute myocardial infarction patients in national institute of cardiovascular disease in Bangladesh

2014 ◽  
Vol 42 (1) ◽  
pp. 3-6
Author(s):  
SS Shahina ◽  
JU Ahmed ◽  
S Ahmed ◽  
E Shahriar ◽  
MN Uddin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Myocardial Injury ◽  
Troponin I ◽  
Clinical Symptoms ◽  
Cardiac Injury ◽  
Circadian Variation ◽  
Assay Method ◽  
Ctni Level

Troponin I (cTnI) isoform is cardiac muscle specific protein and shown to have several features as a preferred marker of myocardial injury. It rises early in acute myocardial infarction (AMI) and attains levels that are clearly separated from baseline values. It remains elevated for several days providing a long window for detection of cardiac injury. The objective of the study was to evaluate for the profile of cTnI level among symptomatic AMI patients. The study was conducted at National Institute of Cardiovascular Disease, Dhaka, Bangladesh from July 2007 to June 2008 and total 9552 patients with type 1 or type 2 MI were included. Blood Sample was taken within 3 days of symptoms and cTnI was measured by chemiluminescent immunometric assay method. cTnI was considered positive when the value was >1ng/ml and study population was divided as per age, sex and cTnI level. The mean (+ SD) age of all patients was 55(+ 12.8) years and majority was males (82.20%). Seasonal variation showed highest positive cases in winter. In case of circadian variation positive cTnI results were suggestive of morning peak of AMI. Positive results were obtained in 32.3% of Cases. cTnI is now considered as a better indicator of myocardial injury. Further study in depth is necessary to correlate with clinical symptoms and other diagnostic tests to make a complete profile of AMI according to the latest subtypes. DOI: http://dx.doi.org/10.3329/bmj.v42i1.18969 Bangladesh Med J. 2013 Jan; 42 (1): 3-6

Abstract P094: Weekly Variation of Circadian Peaks for the Onset of Acute Myocardial Infarction in the Working Population

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Hiroshi Sato ◽  
Ryuya Edahiro ◽  
Daisaku Nakatani ◽  
Shinichiro Suna ◽  
Masaya Usami ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Circadian Variation ◽  
Working Population ◽  
Coronary Insufficiency ◽  
Morning Peak ◽  
Acute Coronary Insufficiency ◽  
Study Population ◽  
Male Patients ◽  
Working Status

Variations in the incidence of acute myocardial infarction (AMI) during the day and week may differ among the subpopulations within the communities. It is well known that AMI onset shows characteristic circadian variations involving a definite morning peak and a vague nighttime peak: the former is often explained by biologic rhythms, while the latter by socioeconomic factors. Interestingly, we previously found that female patients aged 65 years or more showed a morning peak alone, whereas and male patients aged less than 65 years with an occupation and the habits of cigarette smoking and alcohol intake showed a nighttime peak alone. On the other hand, it is also reported that working population shows a weekly variation with an increased incidence for the AMI onset on Mondays. Accordingly, circadian variation for the onset of AMI could be influenced by each or combination of working status, gender, and the day of the week. However, there are few reports investigating circadian variation of AMI onset in relation with working status, gender and/or weekly variation. Therefore, we sought to investigate circadian variation patterns of AMI onset in relation with week variation according to gender and/or working status, especially in the working populations. From the registry database of the Osaka Acute Coronary Insufficiency Study (OACIS), a prospective observational study of AMI in Osaka area, Japan, a total of 7755 consecutive patients whose time of AMI onset was definitely identified between 1998 and 2009 were enrolled. The mean age of study population was 66+12 years old, 5872 (76%) were male, and 3364 (48%) had occupation. As previously reported, an increased incidence of AMI onset was observed in the morning and at the nighttime in overall populations. Interestingly, however, subgroup analysis revealed that the nighttime peak was completely attributable to the increase of nighttime onset on the weekend in the working subjects, especially working men, whereas the morning peak was common throughout the week with a peak on Monday in all other subgroups. As the weekend nighttime peak for AMI onset was not evident in other subgroups, this phenomenon may account for the social and/or economic reasons on the weekend in the working population. Although confirmation in other cohorts is required, this finding may help identify triggers of AMI and guide subjects to prevent an onset of AMI.

scholarly journals Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction

2016 ◽  
Vol 62 (12) ◽  
pp. 1602-1611 ◽  
Author(s):  
Lieke J J Klinkenberg ◽  
Karin Wildi ◽  
Noreen van der Linden ◽  
Imre W K Kouw ◽  
Marijke Niens ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Diagnostic Accuracy ◽  
Diurnal Rhythm ◽  
Cardiac Troponin ◽  
Circadian Variation ◽  
Early Morning ◽  
Random Fluctuation ◽  
Diagnostic Study ◽  
Coronary Syndrome

Abstract BACKGROUND Interpretation of serial high-sensitivity cardiac troponin (hs-cTn) measurements for the diagnosis of acute myocardial infarction (AMI) assumes random fluctuation of hs-cTn around an individual's homeostatic set point. The aim of this study was to challenge this diagnostic concept. METHODS Study 1 examined the presence of a diurnal hs-cTn rhythm by hourly blood sampling, day and night, in 24 individuals without a recent history of AMI. Study 2 assessed morning vs evening diagnostic accuracy of hs-cTnT and hs-cTnI in a prospective multicenter diagnostic study of 2782 unselected patients, presenting to the emergency department with acute chest pain. RESULTS In study 1, hs-cTnT, but not hs-cTnI, exhibited a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime, to peak concentrations in the morning (mean 16.2 ng/L at 8:30 AM and 12.1 ng/L at 7:30 PM). In study 2, the hs-cTnT rhythm was confirmed by higher hs-cTnT concentrations in early-morning presenters compared to evening presenters with an adjudicated diagnosis of noncardiac disease. The diagnostic accuracy [area under the receiver-operation characteristics curve (AUC)] of hs-cTnT at presentation, 1 h, and for the combination of absolute changes with presenting concentration, were very high and comparable among patients presenting early morning as compared to evening (all AUC >0.93). hs-cTnI exhibited no diurnal rhythm with no differences in AUC among early-morning and evening presenters. CONCLUSIONS Rhythmic diurnal variation of hs-cTnT is a general phenomenon that is not seen with hs-cTnI. While the diurnal hs-cTnT rhythm does not seem to affect the diagnostic accuracy of hs-cTnT for AMI, it should be considered when using hs-cTnT for screening purposes. Clinical Trial Registration 1. Circadian Variation of Cardiac Troponin, NCT02091427, www.clinicaltrials.gov/ct2/show/NCT02091427. 2. Advantageous Predictors of Acute Coronary Syndrome Evaluation (APACE) Study, NCT00470587, www.clinicaltrials.gov/ct2/show/NCT00470587.

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