scholarly journals Relationship Between Coronary Events and Serum Cholesterol During 10 Years of Low-Dose Simvastatin Therapy

2008 ◽  
Vol 72 (8) ◽  
pp. 1218-1224 ◽  
Author(s):  
Hiroshige Itakura ◽  
Toru Kita ◽  
Hiroshi Mabuchi ◽  
Masunori Matsuzaki ◽  
Yuji Matsuzawa ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Low Dose ◽  
Simvastatin Therapy ◽  
Coronary Events

scholarly journals Obesity as a Risk Factor for Coronary Events in Japanese Patients with Hypercholesterolemia on Low-Dose Simvastatin Therapy

2010 ◽  
Vol 17 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Yasushi Saito ◽  
Toru Kita ◽  
Hiroshi Mabuchi ◽  
Masunori Matsuzaki ◽  
Yuji Matsuzawa ◽  
...  
Keyword(s):  
Risk Factor ◽  
Low Dose ◽  
Japanese Patients ◽  
Simvastatin Therapy ◽  
Coronary Events

Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia

1986 ◽  
Vol 61 (3) ◽  
pp. 219-223 ◽  
Author(s):  
T. Heinemann ◽  
O. Leiss ◽  
K. von Bergmann
Keyword(s):  
Serum Cholesterol ◽  
Low Dose

scholarly journals Eicosapentaenoic Acid Based Therapies: Fish Facts and Stories

2020 ◽  
pp. 1-9
Author(s):  
Aravind Reddy Kuchkuntla ◽  
◽  
Sri Harsha Patllola ◽  
Keyword(s):  
Eicosapentaenoic Acid ◽  
Inflammatory Markers ◽  
Metabolic Profile ◽  
Low Dose ◽  
Coronary Plaque ◽  
High Dose ◽  
Preventive Cardiology ◽  
Cardio Protection ◽  
Cvd Prevention ◽  
Coronary Events

The significant hypo-lipidemic, anti-thrombotic and anti-inflammatory features of EPA created extensive interest in preventive cardiology from the early 90s, since then several clinical studies were conducted to study the mechanisms and benefits of fish oil use. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are essential FAs therefore, they must be provided in diet or in the form of supplements. The supplements are low dose combinations of EPA and DHA have no significant benefits in terms of CVD prevention in clinical trials. However, a high dose Ethyl ester formulation of EPA has shown a 25% reduction of major adverse coronary events in the secondary prevention. Cardio-protective potential of EPA is attributed to its triglyceride lowering effect, reduction in inflammatory markers, improving coronary plaque stability, anti-platelet effect and improvements of over-all metabolic profile. We intend to provide preventive and therapeutic potentials of EPA in CVD, mechanisms of cardio protection, available evidence and future trails.

scholarly journals Effect of modification of thyroid function on cholesterol 7α-hydroxylation in rat liver

1975 ◽  
Vol 148 (3) ◽  
pp. 499-503 ◽  
Author(s):  
N Takeuchi ◽  
M Ito ◽  
K Uchida ◽  
Y Yamamura
Keyword(s):  
Thyroid Function ◽  
Serum Cholesterol ◽  
Cholesterol Synthesis ◽  
Low Dose ◽  
Cholesterol Concentration ◽  
Hydroxylase Activity ◽  
Synthetic Enzymes ◽  
Glucose Administration ◽  
Serum Cholesterol Concentration ◽  
High Doses

Hepatic activities of cholesterol synthesis and cholesterol 7 alpha-hydroxylation were determined in hyper- and hypo-thyroid rats after oral administration of glucose or cholesterol. Increases in activities of both cholesterol synthesis and cholesterol 7 alpha-hydroxylation induced by glucose administration were enhanced by pretreatment with thyroid powder but suppressed by pretreatment with thiouracil. The enhancement of 7 alpha-hydroxylation was produced by a relatively small amount of thyroid powder, but high doses were required to increase cholesterol synthesis. On the other hand, the suppression of 7 alpha-hydroxylation was brought about by a low dose of thiouracil, but high doses were required to decrease cholesterol synthesis. Although cholesterol synthesis increased similarly in both hypo- and hyper-thyroid rats after glucose administration, hydroxylase activity in hypothyroid rats began to increase more slowly and was always lower than that in hyperthyroid rats. Thus it is concluded that cholesterol 7 alpha-hydroxylase activity is more sensitive to thyroid function than are activities of cholesterol-synthetic enzymes. When exogenous cholesterol was given, hypothyroid rats showed a larger increase in serum cholesterol concentration than hyperthyroid rats, and there was an inverse relationship between serum cholesterol concentrations and hepatic cholesterol 7 alpha-hydroxylase activities.

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