scholarly journals Incidence of Major Bleeding Complication of Warfarin Therapy in Japanese Patients With Atrial Fibrillation

2007 ◽  
Vol 71 (5) ◽  
pp. 761-765 ◽  
Author(s):  
Shinya Suzuki ◽  
Takeshi Yamashita ◽  
Takeshi Kato ◽  
Tadashi Fujino ◽  
Koichi Sagara ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Major Bleeding ◽  
Bleeding Complication ◽  
Warfarin Therapy ◽  
Japanese Patients ◽  
Major Bleeding Complication

The impact of blood pressure on the risk of major bleeding complication after renal transplant biopsy

2021 ◽  
Author(s):  
Winston T. Wang ◽  
Anika G. Patel ◽  
Nan Zhang ◽  
Scott W. Young ◽  
J. Scott Kriegshauser ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Transplant ◽  
Major Bleeding ◽  
Bleeding Complication ◽  
Major Bleeding Complication ◽  
The Impact ◽  
Transplant Biopsy

scholarly journals Regional Differences in Frequency of Warfarin Therapy and Thromboembolism in Japanese Patients With Non-Valvular Atrial Fibrillation　– Analysis of the J-RHYTHM Registry –

2016 ◽  
Vol 80 (7) ◽  
pp. 1548-1555 ◽  
Author(s):  
Hiroshi Inoue ◽  
Hirotsugu Atarashi ◽  
Eitaro Kodani ◽  
Ken Okumura ◽  
Takeshi Yamashita ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Regional Differences ◽  
Warfarin Therapy ◽  
Japanese Patients

scholarly journals Japanese Patients’ and Physicians’ Preferences for Anticoagulant Use in Atrial Fibrillation: Results from a Discrete-choice Experiment

10.36469/9904 ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 207-220 ◽  
Author(s):  
Ken Okumura ◽  
Hiroshi Inoue ◽  
Masahiro Yasaka ◽  
Juan Marcos Gonzalez ◽  
A. Brett Hauber ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Discrete Choice Experiment ◽  
Discrete Choice ◽  
Major Bleeding ◽  
Stroke Prevention ◽  
Choice Experiment ◽  
Clinical Decision Making ◽  
Japanese Patients ◽  
Risk Of Bleeding ◽  
Increased Risk

Background: Anticoagulants are recommended for stroke prevention in patients with atrial fibrillation (AF), but are associated with an increased risk of bleeding; therefore, physicians face benefit-risk tradeoffs when prescribing anticoagulants to AF patients. Although the unmet medical need for safer anticoagulants has been well-documented, there is limited information about the importance that patients and physicians place on cardiovascular events. Objectives: The aim of this study was to quantify patients’ and physicians’ willingness to accept tradeoffs between the benefits and risks of anticoagulants in order to 1) document the potential differences between patients’ and physicians’ perceptions of benefits and risks and 2) support physicians’ clinical decision making. Methods: Preferences from Japanese AF patients and board-eligible or board-certified physicians were elicited using a discrete-choice experiment. Random-parameters logit models were used to estimate importance weights for treatment-related changes in the annual risk of stroke, myocardial infarction, embolism, and bleeding. Results: Japanese patients (N=152) and physicians (N=164) showed different preferences. In particular, among non-fatal outcomes, patients considered disabling stroke to be 16 times more important than non-major clinically relevant bleeding and 2.6 times more important than extra-cranial major bleeding. In contrast, physicians considered the same stroke risk to be 2.7 times more important than non-major clinically relevant bleeding and equally important as major bleeding. Conclusions: Results suggest that Japanese patients are willing to tolerate a greater risk of bleeding in exchange for stroke prevention than are Japanese physicians. The findings demonstrate the importance of physician-patient communication in treatment decisions involving stroke preventative therapies.

Real-World Outcomes of Rivaroxaban Treatment in Patients with Both Nonvalvular Atrial Fibrillation and a History of Ischemic Stroke/Transient Ischemic Attack

2019 ◽  
Vol 48 (1-2) ◽  
pp. 53-60 ◽  
Author(s):  
Kazuo Minematsu ◽  
Takanori Ikeda ◽  
Satoshi Ogawa ◽  
Takanari Kitazono ◽  
Jyoji Nakagawara ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Weight ◽  
Ischemic Stroke ◽  
Major Bleeding ◽  
Real World ◽  
Transient Ischemic Attack ◽  
Japanese Patients ◽  
Risk Scores ◽  
Nonvalvular Atrial Fibrillation ◽  
Ischemic Attack

Introduction: Prior stroke is a risk factor for stroke and bleeding during anticoagulation in patients with atrial fibrillation (AF). Although rivaroxaban is widely prescribed to reduce their risk of stroke in patients with nonvalvular AF (NVAF), the real-world evidence on rivaroxaban treatment is limited. We aimed to examine the outcomes of rivaroxaban treatment in NVAF patients with prior ischemic stroke/transient ischemic attack (TIA) by using the data of the Xarelto Post-Authorization Safety and Effectiveness Study in Japanese ­Patients with AF, a prospective, single-arm, observational study. Methods: The clinical outcomes of 9,578 patients who completed the 1-year follow-up were evaluated. Safety and effectiveness outcomes were compared between patients with and without prior ischemic stroke/TIA. Results: Among the patients, 2,153 (22.5%) had prior ischemic stroke/TIA. They were significantly older and had lower body weight, lower creatinine clearance, higher CHADS2, CHA2DS2-VASc, and modified HAS-BLED scores as compared to those without prior ischemic stroke/TIA. Any bleeding (9.1 vs. 7.2 events per 100 patient-years), major bleeding (2.3 vs. 1.6 events per 100 patient-years), and stroke/non-central nervous system systemic embolism/myocardial infarction (3.4 vs. 1.3 events per 100 patient-years) were more frequent in patients with prior ischemic stroke/TIA. Stepwise regression analysis suggested that body weight of ≤50 kg and diabetes mellitus were predictive of major bleeding in patients with prior ischemic stroke/TIA. Conclusions: Safety and effectiveness event rates were higher in patients with prior ischemic stroke/TIA than those without. This might be explained by differences in several risk profiles including age, body weight, renal function, and risk scores such as CHADS2 between the groups. Clinicaltrials.gov: NCT01582737.

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