scholarly journals Plasma Levels of Uridine Correlate With Blood Pressure and Indicators of Myogenic Purine Degradation and Insulin Resistance in Hypertensive Patients

2007 ◽  
Vol 71 (3) ◽  
pp. 354-356 ◽  
Author(s):  
Toshihiro Hamada ◽  
Einosuke Mizuta ◽  
Kiyotaka Yanagihara ◽  
Yasuhiro Kaetsu ◽  
Shinobu Sugihara ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Plasma Levels ◽  
Hypertensive Patients ◽  
Purine Degradation

Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients

2005 ◽  
Vol 7 (3) ◽  
pp. 246-253 ◽  
Author(s):  
A. N. Faria ◽  
F. F. Ribeiro Filho ◽  
N. E. Kohlmann ◽  
S. R. Gouvea Ferreira ◽  
M. T. Zanella
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Fat Mass ◽  
Abdominal Fat ◽  
Hypertensive Patients

P0152EFFECT OF LOSARTAN ON AMBULATORY SHORT-TERM BLOOD PRESSURE VARIABILITY AND CARDIOVASCULAR REMODELING IN HYPERTENSIVE PATIENTS ON HEMODIALYSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Koichi Azuma
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Plasma Levels ◽  
Inhibitory Effect ◽  
Left Ventricular ◽  
Control Treatment ◽  
Control Group ◽  
Short Term ◽  
Hypertensive Patients ◽  
Cardiovascular Remodeling

Abstract Background and Aims Previous studies have shown increases in ambulatory short-term blood pressure (BP) variability to be related to cardiovascular disease. In this study, we examined whether an angiotensin II type 1 receptor blocker losartan would improve ambulatory short-term BP variability in hypertensive patients on hemodialysis. Method 40 hypertensive patients on hemodialysis therapy were randomly assigned to the losartan treatment group (n=20) or the control treatment group (n=20). At baseline and 6 and 12 months after the treatment, 24-h ambulatory BP monitoring was performed. Echocardiography and measurements of brachial-ankle pulse wave velocity (baPWV) and biochemical parameters were also performed before and after therapy. Results After 6- and 12-months of treatment, nighttime short-term BP variability, assessed on the basis of the coefficient of variation of ambulatory BP, was significantly decreased in the losartan group, but remained unchanged in the control group. Compared with the control group, losartan significantly decreased left ventricular mass index (LVMI), baPWV, and the plasma levels of brain natriuretic peptide and advanced glycation end products (AGE). Furthermore, multiple regression analysis showed significant correlations between changes in LVMI and changes in nighttime short-term BP variability, as well as between changes in LVMI and changes in the plasma levels of AGE. Conclusion These results suggest that losartan is beneficial for the suppression of pathological cardiovascular remodeling though its inhibitory effect on ambulatory short-term BP variability during nighttime.

Comparative effects of N-acetyl-l-cysteine and ramipril on arterial hypertension, insulin resistance, and oxidative stress in chronically glucose-fed rats

2008 ◽  
Vol 86 (11) ◽  
pp. 752-760 ◽  
Author(s):  
Adil El Midaoui ◽  
Mahmoud Ali Ismael ◽  
Huogen Lu ◽  
I. George Fantus ◽  
Jacques de Champlain ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Nadph Oxidase ◽  
Plasma Levels ◽  
Superoxide Anion ◽  
Oxidase Activity ◽  
Therapeutic Effects ◽  
Superoxide Anion Production ◽  
Nadph Oxidase Activity

Beneficial effects of an antioxidant (N-acetyl-l-cysteine, NAC) and an angiotensin I-converting enzyme (ACE) inhibitor (ramipril) were assessed in a rat model of insulin resistance induced by 10% glucose feeding for 20 weeks. Treatments with NAC (2 g/kg per day) and ramipril (1 mg/kg per day) were initiated at 16 weeks in the drinking fluid. Systolic blood pressure, plasma levels of insulin and glucose, and insulin resistance were significantly higher in rats treated with glucose for 20 weeks. This was associated with a higher production of superoxide anion and NADPH oxidase activity in aorta and liver and with a marked reduction in protein expression of skeletal muscle insulin receptor substrate-1 (IRS-1) in the gastrocnemius muscle. NAC prevented all these alterations. Although ramipril also reversed high blood pressure, it had a lesser effect on insulin resistance (including IRS-1) and blocked superoxide anion production only in aorta. Ramipril, in contrast to NAC, did not reduce NADPH oxidase activity in aorta and liver or plasma levels of 4-hydroxynonenal and malondialdehyde. Results suggest that the inhibition of the oxidative stress in hypertensive and insulin-resistant states contributes to the therapeutic effects of NAC and ramipril. Whereas NAC exerts effective antioxidant activity in multiple tissues, ramipril appears to preferentially target the vasculature.

Olmesartan/Amlodipine Combination Versus Olmesartan or Amlodipine Monotherapies on Blood Pressure and Insulin Resistance in a Sample of Hypertensive Patients

2012 ◽  
Vol 35 (5) ◽  
pp. 301-307 ◽  
Author(s):  
Giuseppe Derosa ◽  
Arrigo F.G. Cicero ◽  
Anna Carbone ◽  
Fabrizio Querci ◽  
Elena Fogari ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Hypertensive Patients

scholarly journals Study of Serum Insulin Level in Hypertensive Patients

1970 ◽  
Vol 4 (1) ◽  
pp. 13-16
Author(s):  
MN Uddin ◽  
MZ Ali ◽  
NWB Jahan ◽  
MA Rashid ◽  
MK Sultan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Serum Insulin ◽  
Study Groups ◽  
Serum Glucose ◽  
Ionized Calcium ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
Serum Ionized Calcium ◽  
The Relationship

Background and aims: Hypertension is a frequent and almost ubiquitous health disorder, prevalent both in developed and developing countries. Hyperinsulinemia and insulin resistance have been suggested to be closely associated with the pathogenesis of essential hypertension. However there is considerable controversy in this regards. The present study was designed to explore the relationship between serum insulin and serum ionized calcium in non diabetic and diabetic hypertensive subjects. Subjects and Methods: A total of 57 hypertensive and diabetic hypertensive patients attending out patients department of the BIRDEM and NICVD were included in the study. Fasting serum glucose was measured by glucose oxidase method, lipid profile was measured by enzymatic method. Serum insulin was measured by Enzyme Linked Immunosorbent assay (ELISA) method and serum ionized calcium by the Ion Sensitive Electrode (ISE) technique. Results: Glucose-insulin ratios were calculated as the index for insulin. Serum insulin (pmol/ml), Mean ± SD, 147 ± 48 in DC and 170 ± 80 in DH groups vs 118 ± 21 in NC and 120 ± 41 in EH groups, p= 0.023 and p= 0.031 respectively. Although, from the serum insulin results, the diabetic groups seemed to have insulin resistance, the glucose-insulin ratios in the two groups were significantly lower compared to nondiabetic groups (Glucose-insulin ratio, mmol/pmol, 0.066 ± 0.025 in DC, 0.074 ± 0.025 in DH vs 0.044 ± 0.11 in NC, 0.043 ± 0.012 in EH, p= 0.005 - 0.0001). The serum ionized calcium in the healthy subject, first time reported in the country by an up to date method (1.17 ± 0.05 M ± SD), were within the range found in healthy subjects of the other populations. No significant difference in the serum Ca2+ could be found between any of the study groups. Also, serum Ca2+ did not correlate with blood pressure, glucose or insulin in any of the study groups or with all the patients as a whole. Serum total cholesterol, triglyceride, HDLc and LDLc levels in the DC, EH and DH group did not show any significant difference compared to NC group and among the groups. The lipid abnormality as reflected by the mean LDL-HDL cholesterol ratios was the highest in the DH group but the differences were not statistically significant compared to the NC, DC and EH group. Conclusions: The data suggest the following conclusions: a) Serum ionized calcium level in our population is similar to that reported for other population. b) Serum glucose and insulin by themselves do not have any direct influence on serum ionized calcium. c) Non obese diabetes mellitus subjects in our population do not show insulin resistance as the primary defect. Rather, there is significant decompensation of the insulin secretory capacity in the subjects. d) Insulin resistance should be measured directly in relation to blood pressure and Ca2+ in appropriate groups of subjects to explore the relationship between insulin resistance, hyperinsulinemia and serum ionized calcium. Keywords: Serum Insulin; Hypertension DOI: http://dx.doi.org/10.3329/cardio.v4i1.9384 Cardiovasc. J. 2011; 4(1): 13-16

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