scholarly journals Nocturnal blood pressure but not insulin resistance influences endothelial function in treated hypertensive patients

2010 ◽  
Vol 25 (1) ◽  
pp. 18-24 ◽  
Author(s):  
T Konrad ◽  
S Franke ◽  
F Schneider ◽  
F Bär ◽  
G Vetter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Endothelial Function ◽  
Hypertensive Patients ◽  
Nocturnal Blood Pressure

scholarly journals Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study

2019 ◽  
Vol 20 (3) ◽  
pp. 147032031986889 ◽  
Author(s):  
Piotr Ruszkowski ◽  
Anna Masajtis-Zagajewska ◽  
Michał Nowicki
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Angiotensin Converting Enzyme ◽  
Endothelial Function ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
C Reactive Protein ◽  
Double Blind ◽  
Hypertensive Patients ◽  
Reactive Protein

Background: The aim of this study was to compare the influence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on endothelial function and blood pressure in patients with essential hypertension on long-term angiotensin-converting enzyme inhibitor therapy. Method: The study was designed as a prospective, double-blind, randomised, placebo controlled, crossover clinical trial. Twenty patients with essential hypertension were treated with an angiotensin-converting enzyme inhibitor; the control group included 10 healthy subjects. Hypertensive patients received in random order 80 mg of fluvastatin daily or placebo for 6 weeks. The following parameters were assessed at baseline and after each treatment period: serum lipids, flow-mediated vasodilation, activity of von Willebrand factor, concentration of vascular endothelial growth factor, C-reactive protein and 24-hour blood pressure profile. Results: Hypertensive patients did not differ from healthy subjects with respect to age, body mass and biochemical parameters, with the exception of C-reactive protein, which was higher in hypertensive patients ( P=0.02). After statin therapy, low-density lipoprotein cholesterol ( P<0.0001), C-reactive protein ( P=0.03), von Willebrand factor ( P=0.03) and vascular endothelial growth factor ( P<0.01) decreased and flow-mediated vasodilation improved ( P<0.001). Statins had no significant effect on blood pressure. Conclusions: Statins added to angiotensin-converting enzyme inhibitors may improve endothelial function and ameliorate inflammation independently of blood pressure.

Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients

2005 ◽  
Vol 7 (3) ◽  
pp. 246-253 ◽  
Author(s):  
A. N. Faria ◽  
F. F. Ribeiro Filho ◽  
N. E. Kohlmann ◽  
S. R. Gouvea Ferreira ◽  
M. T. Zanella
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Fat Mass ◽  
Abdominal Fat ◽  
Hypertensive Patients

scholarly journals Added Impact of Obesity and Insulin Resistance in Nocturnal Blood Pressure Elevation in Children and Adolescents

Hypertension ◽  
2008 ◽  
Vol 51 (3) ◽  
pp. 635-641 ◽  
Author(s):  
Empar Lurbe ◽  
Isabel Torro ◽  
Francisco Aguilar ◽  
Julio Alvarez ◽  
Jose Alcon ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Children And Adolescents ◽  
Blood Pressure Elevation ◽  
Nocturnal Blood Pressure ◽  
Pressure Elevation
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