scholarly journals Utility of Serum Ratio of Heart-Type Fatty Acid-Binding Protein to Myoglobin for Cardiac Damage Regardless of Renal Dysfunction

2004 ◽  
Vol 68 (7) ◽  
pp. 656-659 ◽  
Author(s):  
Masato Furuhashi ◽  
Nobuyuki Ura ◽  
Koichi Hasegawa ◽  
Kazufumi Tsuchihashi ◽  
Tomoaki Nakata ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Cardiac Damage ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Serum Ratio

scholarly journals Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic pericarditis

2019 ◽  
Vol 67 (4) ◽  
pp. 505-516 ◽  
Author(s):  
Ramazan Yildiz ◽  
Mahmut Ok ◽  
Merve Ider ◽  
Ugur Aydogdu ◽  
Alper Ertürk
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
Clinical Signs ◽  
Control Group ◽  
Pentraxin 3 ◽  
Cardiac Damage ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

The aim of this study was to evaluate the biomarkers of cardiac damage such as heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3), and thrombomodulin (TM) for the detection and prognosis of bovine traumatic pericarditis (TP). Spontaneous TP was diagnosed on the basis of history, clinical signs, complete blood count, glutaraldehyde test, ultrasonography, and pericardiocentesis findings. H-FABP, PTX-3 and TM levels in serum were compared between 25 Holstein cows diagnosed with spontaneous TP and 10 healthy control cows using bovine-specific ELISA kits. Serum H-FABP in cattle with TP was significantly (P < 0.05) higher than in the control group and positively correlated with cardiac troponin-I (cTnI), creatine kinase myocardial band (CK-MB), PTX-3 and TM (r = 0.683, 0.342, 0.448 and 0.424, respectively; P < 0.05). The serum levels of PTX-3 (P < 0.05) and TM (P < 0.05) in cattle with TP were significantly higher than in the control group. Cardiac damage biomarkers H-FABP, PTX-3 and TM may be useful in the diagnosis of bovine TP.

Serum Ratio of Heart-Type Fatty Acid-Binding Protein to Myoglobin

2004 ◽  
Vol 93 (2) ◽  
pp. c69-c74 ◽  
Author(s):  
Masato Furuhashi ◽  
Nobuyuki Ura ◽  
Koichi Hasegawa ◽  
Hideaki Yoshida ◽  
Kazufumi Tsuchihashi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Serum Ratio

scholarly journals Evaluation of Heart-Type Fatty-Acid–Binding Protein for Early Detection of Intraoperative Cardiac Damage

2008 ◽  
Vol 28 (2) ◽  
pp. 133-146
Author(s):  
Amira Hassouna ◽  
Salwa fayez ◽  
Emad Sarawy ◽  
Mohamed El-Badawy ◽  
Mohamed Othman ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Early Detection ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Cardiac Damage ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Significance of urinary fatty acid-binding protein 4 level as a possible biomarker for the identification of minimal change disease in patents with nephrotic-range proteinuria

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Marenao Tanaka ◽  
Masato Furuhashi ◽  
Norihito Moniwa ◽  
Takuto Maeda ◽  
Hideki Takizawa ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Characteristic Curve ◽  
Minimal Change ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Nephrotic Range Proteinuria

Abstract Background Fatty acid-binding protein 4 (FABP4), but not FABP1 (liver-type FABP), is ectopically induced in injured glomerular endothelial cells, and urinary FABP4 (U-FABP4) level is associated with proteinuria and renal dysfunction in a general population. Methods The clinical significance of U-FABP4 was investigated in 81 patients (male/female: 43/38, age: 57 ± 17 years) who underwent kidney biopsy. Results U-FABP4 was negatively correlated with estimated glomerular filtration rate (eGFR) (r = − 0.56, P < 0.01) and was positively correlated with age, blood pressure, triglycerides, proteinuria (r = 0.58, P < 0.01), plasma FABP4 and urinary FABP1 (U-FABP1) (r = 0.52, P < 0.01). Multivariable regression analysis showed that eGFR, proteinuria and U-FABP1 were independent predictors of U-FABP4. The level of U-FABP4, but not that of proteinuria, eGFR or U-FABP1, in minimal change nephrotic syndrome (MCNS) was significantly lower than the level in membranous nephropathy (MN) and that in diabetic nephropathy. Receiver operating characteristic curve analysis indicated that U-FABP4 level ≤ 0.78 μg/gCr predicted MCNS in patients who had nephrotic-range proteinuria with a high level of accuracy. When divided by the median value of U-FABP4 at baseline in 33 of the 81 patients who could be followed up, the yearly change (post–pre) in eGFR in the low U-FABP4 group was significantly greater than that in the high U-FABP4 group (median: 11.0 vs. -5.0 mL/min/1.73m2/year). Conclusions U-FABP4 level is independently associated with proteinuria and renal dysfunction in patients with glomerular kidney disease. A low U-FABP4 level may predict MCNS in patients with nephrotic syndrome and would be a useful biomarker for differential diagnosis of MCNS and MN, which are common causes of nephrotic syndrome.

Early Detection of Cardiac Damage With Heart Fatty Acid-Binding Protein After Cardiac Operations

1998 ◽  
Vol 65 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Ken Suzuki ◽  
Yoshiki Sawa ◽  
Keishi Kadoba ◽  
Toshiki Takahashi ◽  
Hajime Ichikawa ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Early Detection ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Cardiac Damage ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Cardiac Operations

scholarly journals The use of biomarkers in detecting subclinical cardiotoxicity in doxorubicin-based treatment for paediatric patients with acute lymphoblastic leukaemia

2017 ◽  
Vol 25 (2) ◽  
Author(s):  
Letiția Elena Radu ◽  
Andra Beldiman ◽  
Ioana Ghiorghiu ◽  
Alina Oprescu ◽  
Constantin Arion ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Clinical Signs ◽  
Treatment Protocol ◽  
Cardiac Damage ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

AbstractThe international standard protocol for acute lymphoblastic leukaemia (ALL), the most common haemato-oncological pathology at paediatric age, uses anthracyclines as antitumor agents, potentially associated with early or late onset cardiac damage. Currently, echocardiography is the gold standard in the diagnosis of cardiotoxicity, but several biomarkers are evaluated as a possible replacement, pending more extensive clinical studies. We started a prospective study in order to determine the role of two biomarkers, troponin and heart-type fatty acid binding protein, in the evaluation of cardiotoxicity in children over one year of age, diagnosed with ALL. Between February 2015 and April 2016, 20 patients were enrolled and monitored at diagnosis, during chemotherapy and four months after the end of reinduction, through cardiac evaluation and dosing of those two markers in five different points of the treatment protocol. During the first year of follow-up, the patients did not develop clinical signs of cardiac damage, but the study showed a slight increase in troponin levels during chemotherapy, with the return to baseline value after treatment cessation, and also a correlation with the total dose of anthracyclines given to the patient. On the other hand, the second biomarker, heart-type fatty acid binding protein, did not seem to be useful in detecting subclinical cardiac damage in these patients.

Ectopic Expression of Fatty Acid-Binding Protein 4 in the Glomerulus Is Associated with Proteinuria and Renal Dysfunction

2015 ◽  
Vol 128 (3-4) ◽  
pp. 345-351 ◽  
Author(s):  
Marenao Tanaka ◽  
Masato Furuhashi ◽  
Yusuke Okazaki ◽  
Tomohiro Mita ◽  
Takahiro Fuseya ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Ectopic Expression ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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