Ectopic Expression of Fatty Acid-Binding Protein 4 in the Glomerulus Is Associated with Proteinuria and Renal Dysfunction

2015 ◽  
Vol 128 (3-4) ◽  
pp. 345-351 ◽  
Author(s):  
Marenao Tanaka ◽  
Masato Furuhashi ◽  
Yusuke Okazaki ◽  
Tomohiro Mita ◽  
Takahiro Fuseya ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Ectopic Expression ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases

2014 ◽  
Vol 8s3 ◽  
pp. CMC.S17067 ◽  
Author(s):  
Masato Furuhashi ◽  
Shigeyuki Saitoh ◽  
Kazuaki Shimamoto ◽  
Tetsuji Miura
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Cardiovascular Diseases ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Ectopic Expression ◽  
Classical Pathway ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
And Function

Over the past decade, evidences of an integration of metabolic and inflammatory pathways, referred to as metaflammation in several aspects of metabolic syndrome, have been accumulating. Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation. Despite lack of a typical secretory signal peptide, FABP4 has been shown to be released from adipocytes in a non-classical pathway associated with lipolysis, possibly acting as an adipokine. Elevation of circulating FABP4 levels is associated with obesity, insulin resistance, diabetes mellitus, hypertension, cardiac dysfunction, atherosclerosis, and cardiovascular events. Furthermore, ectopic expression and function of FABP4 in several types of cells and tissues have been recently demonstrated. Here, we discuss both the significant role of FABP4 in pathophysiological insights and its usefulness as a biomarker of metabolic and cardiovascular diseases.

scholarly journals Significance of urinary fatty acid-binding protein 4 level as a possible biomarker for the identification of minimal change disease in patents with nephrotic-range proteinuria

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Marenao Tanaka ◽  
Masato Furuhashi ◽  
Norihito Moniwa ◽  
Takuto Maeda ◽  
Hideki Takizawa ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Characteristic Curve ◽  
Minimal Change ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Nephrotic Range Proteinuria

Abstract Background Fatty acid-binding protein 4 (FABP4), but not FABP1 (liver-type FABP), is ectopically induced in injured glomerular endothelial cells, and urinary FABP4 (U-FABP4) level is associated with proteinuria and renal dysfunction in a general population. Methods The clinical significance of U-FABP4 was investigated in 81 patients (male/female: 43/38, age: 57 ± 17 years) who underwent kidney biopsy. Results U-FABP4 was negatively correlated with estimated glomerular filtration rate (eGFR) (r = − 0.56, P < 0.01) and was positively correlated with age, blood pressure, triglycerides, proteinuria (r = 0.58, P < 0.01), plasma FABP4 and urinary FABP1 (U-FABP1) (r = 0.52, P < 0.01). Multivariable regression analysis showed that eGFR, proteinuria and U-FABP1 were independent predictors of U-FABP4. The level of U-FABP4, but not that of proteinuria, eGFR or U-FABP1, in minimal change nephrotic syndrome (MCNS) was significantly lower than the level in membranous nephropathy (MN) and that in diabetic nephropathy. Receiver operating characteristic curve analysis indicated that U-FABP4 level ≤ 0.78 μg/gCr predicted MCNS in patients who had nephrotic-range proteinuria with a high level of accuracy. When divided by the median value of U-FABP4 at baseline in 33 of the 81 patients who could be followed up, the yearly change (post–pre) in eGFR in the low U-FABP4 group was significantly greater than that in the high U-FABP4 group (median: 11.0 vs. -5.0 mL/min/1.73m2/year). Conclusions U-FABP4 level is independently associated with proteinuria and renal dysfunction in patients with glomerular kidney disease. A low U-FABP4 level may predict MCNS in patients with nephrotic syndrome and would be a useful biomarker for differential diagnosis of MCNS and MN, which are common causes of nephrotic syndrome.

scholarly journals Osteopontin and fatty acid binding protein (FABP), as biomarkers of cyclophosphamide nephrotoxicity, in an experimental model of cystitis in rats

2019 ◽  
Vol 73 ◽  
pp. 282-293 ◽  
Author(s):  
Łukasz Dobrek ◽  
Zbigniew Arent ◽  
Klaudia Nalik-Iwaniak ◽  
Kinga Fic
Keyword(s):  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Urinary Concentration ◽  
Chronic Cystitis ◽  
Control Groups ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Group 2

Aim: Cyclophosphamide (CP) is a cytostatic agent, which evokes numerous side effects, including well-known cystitis. Acrolein released during CP biotransformation exerts both urotoxic and nephrotoxic effects, therefore CP may cause renal dysfunction. The aim of the study was to assess kidney function in experimental models of acute and chronic cystitis. Material/Methods: The studies were carried out on 40 rats (4 groups; n = 10), in which acute (single dose of 150 mg/kg CP; group 2) or chronic (four doses of 75 mg/kg CP; group 4) cystitis was induced with appropriate control groups (group 1 and 3). Renal function was assessed with standard (diuresis, urea, creatinine) and new (fatty acid binding protein – FABP and osteopontin) laboratory parameters as well as histopathologically. Results: The histopathological assessment confirmed the presence of acute and chronic cystitis and did not reveal coexisting significant kidney disorders in groups 2 and 4. Group 2 retained urea and creatinine in the blood. Both groups 2 and 4 showed an increase in diurnal diuresis, and a decreased concentration of urea and creatinine was found in the urine, which was accompanied by significant proteinuria. The daily urinary excretion of small-molecule nitrogen compounds did not differ from the values found in the control groups. In addition, both groups 2 and 4 showed an increase in urinary concentration and excretion of FABP and osteopontin with urine. Conclusions: The experiment revealed the renal dysfunction in the course of cyclophosphamide-induced cystitis with the tubulopathy character, expressed by the increased production and release into the urine two markers reflecting acute kidney injury – FABP and osteopontin.

scholarly journals Urinary Excretion of Fatty Acid-Binding Protein 4 is Associated with Albuminuria and Renal Dysfunction

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115429 ◽  
Author(s):  
Yusuke Okazaki ◽  
Masato Furuhashi ◽  
Marenao Tanaka ◽  
Tomohiro Mita ◽  
Takahiro Fuseya ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Urinary Excretion ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Urinary liver-type fatty acid-binding protein levels as a potential risk factor for renal dysfunction in male HIV-infected Japanese patients receiving antiretroviral therapy: a pilot study

2018 ◽  
Vol 29 (14) ◽  
pp. 1424-1431 ◽  
Author(s):  
Shinichi Hikasa ◽  
Shota Shimabukuro ◽  
Kyoko Hideta ◽  
Satoshi Higasa ◽  
Akihiro Sawada ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Antiretroviral Therapy ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Primary Outcome ◽  
Binding Protein ◽  
Area Under The Curve ◽  
Rank Test ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Renal dysfunction is recognized with increasing frequency among the non-infectious co-morbidities associated with human immunodeficiency virus (HIV) infection. Recently, urinary liver-type fatty acid-binding protein (L-FABP) was suggested to be a predictor of the progression of renal dysfunction in patients without HIV. However, little is known regarding the utility of urinary L-FABP as a predictor of renal dysfunction in patients with HIV. A retrospective, observational, single-centre study was conducted between July 2014 and December 2016. The primary outcome was renal dysfunction defined as decrease in estimated glomerular filtration rate to less than 60 ml/min/1.73 m2. To estimate the effect of urinary L-FABP, proteinuria category, and urinary β2 microglobulin (β2MG) on the time to the first event, a log-rank test was performed. Accuracy, determined by area under the curve and calculated from receiver operating characteristic curves, was also assessed. Thirty Japanese outpatients with HIV receiving antiretroviral therapy (ART) were enrolled. The primary outcome occurred in five patients during the follow-up period. Urinary L-FABP level and proteinuria category were significantly associated with renal dysfunction (p = 0.045 and p = 0.037, respectively). In contrast, urinary β2MG level was not significantly associated with renal dysfunction (p = 0.141). Urinary L-FABP was the most accurate predictor of renal dysfunction among the three urinary parameters. In conclusion, urinary L-FABP levels in HIV patients receiving ART were more accurate for predicting renal dysfunction than proteinuria and urinary β2MG. In addition, urinary L-FABP helped to discriminate those patients with a higher risk for renal dysfunction.

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