scholarly journals Release and permeation kinetics of matrix-type transdermal delivery systems for verapamil.

1989 ◽  
Vol 22 (6) ◽  
pp. 689-691 ◽  
Author(s):  
Kakuji Tojo ◽  
Yie W. Chien
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems ◽  
Matrix Type ◽  
Kinetics Of ◽  
Permeation Kinetics

scholarly journals Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 209 ◽  
Author(s):  
Behnam Dasht Bozorg ◽  
Ajay K. Banga
Keyword(s):  
Transdermal Delivery ◽  
Drug Loading ◽  
In Vitro Release ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
Pressure Sensitive Adhesive ◽  
Matrix Type ◽  
Pressure Sensitive ◽  
Percentage Release

Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly affect the permeation, release, and performance characteristics of the system. In this study we aimed to design and characterize transdermal delivery systems formulated with lidocaine—as the model drug—loaded in different PSAs, including silicone, polyisobutylene (PIB), and acrylate. TDS containing lidocaine at its saturation points were prepared by the solvent casting method. In vitro permeation studies across dermatomed porcine ear skin were performed using Franz diffusion cells. In vitro release studies were carried out using USP apparatus 5 (paddle over disk). The cumulative amount permeated from the acrylate was significantly higher than silicone and PIB. The acrylate TDS contained a ten times higher drug amount than silicone TDS, but the permeation flux was only two folds higher. Results also showed the release of drug does not linearly correlate to saturation, as the silicone TDS comprising of the lowest amount of drug loading, showed the highest percentage release indicating the choice of PSA affected the drug release and permeation profile.

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

In vitro/in vivo correlations in the kinetics of poly (lactide-co-glycolide) (PLG) delivery systems of GnRH peptides

1992 ◽  
Vol 21 (1-3) ◽  
pp. 213
Author(s):  
H. Berger ◽  
K. Fechner ◽  
N. Heinrich ◽  
D. Lorenz ◽  
E. Albrecht ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Kinetics Of

Development of antimigraine transdermal delivery systems of pizotifen malate

2015 ◽  
Vol 492 (1-2) ◽  
pp. 223-232 ◽  
Author(s):  
C.E. Serna-Jiménez ◽  
S. del Rio-Sancho ◽  
M.A. Calatayud-Pascual ◽  
C. Balaguer-Fernández ◽  
A. Femenía-Font ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems
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