scholarly journals Expression Analysis of Estrogen-responsive Genes Vitellogenin 1 and 2 in Liver of Male Medaka (Oryzias latipes) Exposed to Selective Ligands of Estrogen Receptor Subtypes

2009 ◽  
Vol 55 (6) ◽  
pp. 930-938 ◽  
Author(s):  
Akemi Yamaguchi ◽  
Hiroshi Ishibashi ◽  
Shinya Kohra ◽  
Koji Arizono ◽  
Keisuke Kato ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Expression Analysis ◽  
Oryzias Latipes ◽  
Receptor Subtypes ◽  
Selective Ligands

scholarly journals Estrogen Receptor β: An Overview and Update

2008 ◽  
Vol 6 (1) ◽  
pp. nrs.06003 ◽  
Author(s):  
Chunyan Zhao ◽  
Karin Dahlman-Wright ◽  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Receptor ◽  
Target Genes ◽  
Expression Patterns ◽  
Estrogen Signaling ◽  
Receptor Subtypes ◽  
Specific Expression ◽  
Microarray Experiments ◽  
Downstream Target ◽  
Animal Disease Models ◽  
Selective Ligands

The discovery of a second estrogen receptor (ER), designated ERβ (NR3A2), has redefined our knowledge about the mechanisms underlying cellular signaling by estrogens and has broad implications for our understanding of regulation of estrogen-responsive tissues. Highly variable and even contrasting effects of estrogens in different tissues seem to be at least partially explained by different estrogen signaling pathways, involving ERα (NR3A1) and/or ERβ. To date, two key conclusions can be drawn from the significant body of work carried out on the specific roles of the two receptor subtypes in diverse estrogen target tissues. First, ERα and ERβ have different biological functions, as indicated by their specific expression patterns and the distinct phenotypes observed in ERα and ERβ knockout (αERKO and βERKO) mice. Second, ERα and ERβ appear to have overlapping but also unique sets of downstream target genes, as judged from a set of microarray experiments. Thus, ERα and ERβ have different transcriptional activities in certain ligand, cell-type, and promoter contexts, which may help to explain some of the major differences in their tissue-specific biological actions. The phenotypes observed for βERKO mice have suggested certain therapeutic areas to be further explored. The development of ERβ-selective ligands active in animal disease models indicates new avenues for clinical exploration. ERβ agonists are being explored and validated as drugs for a growing number of indications. Hopefully, some ERβ targeted drugs will prove to be efficient in enhancing human health.

Gene expression analyses of vitellogenin, choriogenin and estrogen receptor subtypes in the livers of male medaka (Oryzias latipes) exposed to equine estrogens

2016 ◽  
Vol 36 (11) ◽  
pp. 1392-1400 ◽  
Author(s):  
Hiroshi Ishibashi ◽  
Masaya Uchida ◽  
Akiko Koyanagi ◽  
Yoshihiro Kagami ◽  
Teruhiko Kusano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Oryzias Latipes ◽  
Receptor Subtypes ◽  
Gene Expression Analyses ◽  
Equine Estrogens

scholarly journals Expression and Function of Estrogen Receptor Subtypes in Granulosa Cells: Regulation by Estradiol and Forskolin1

Endocrinology ◽  
1999 ◽  
Vol 140 (9) ◽  
pp. 4320-4334 ◽  
Author(s):  
S. Chidananda Sharma ◽  
Jeffrey W. Clemens ◽  
Margareta D. Pisarska ◽  
JoAnne S. Richards
Keyword(s):  
Estrogen Receptor ◽  
Granulosa Cells ◽  
Receptor Subtypes ◽  
And Function

scholarly journals A Computational-Based Approach to Identify Estrogen Receptor α/β Heterodimer Selective Ligands

2018 ◽  
Vol 93 (3) ◽  
pp. 197-207 ◽  
Author(s):  
Carlos G. Coriano ◽  
Fabao Liu ◽  
Chelsie K. Sievers ◽  
Muxuan Liang ◽  
Yidan Wang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Selective Ligands

Design and synthesis of carborane-containing estrogen receptor-beta (ERβ)-selective ligands

2015 ◽  
Vol 25 (19) ◽  
pp. 4174-4178 ◽  
Author(s):  
Kiminori Ohta ◽  
Takumi Ogawa ◽  
Akifumi Oda ◽  
Asako Kaise ◽  
Yasuyuki Endo
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Beta ◽  
Design And Synthesis ◽  
Selective Ligands ◽  
Receptor Beta

Serotonin Receptor Subtypes: Implications for Psychopharmacology

1991 ◽  
Vol 159 (S12) ◽  
pp. 7-14 ◽  
Author(s):  
P. J. Cowen
Keyword(s):  
Cognitive Processes ◽  
Serotonin Receptor ◽  
Antidepressant Treatment ◽  
Receptor Subtypes ◽  
Therapeutic Effects ◽  
Controlled Clinical Trials ◽  
Wide Range ◽  
Selective Ligands ◽  
Coupling Mechanisms ◽  
Therapeutic Possibilities

Serotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. Nevertheless, manipulation of several different 5-HT receptor subtypes (5-HT1A, 5-HT1c, 5-HT2 and 5-HT3) may produce anxiolytic effects; 5-HT1A and 5-HT2 receptors may be involved in the aetiology of major depression and the therapeutic effects of antidepressant treatment; and 5-HT3 receptors have been linked to reward mechanisms and cognitive processes. These advances offer therapeutic possibilities, the value of which can only be satisfactorily assessed by controlled clinical trials.

Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease

2008 ◽  
Vol 196 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Maria Natalia Cruz ◽  
Stefan Agewall ◽  
Karin Schenck-Gustafsson ◽  
Karolina Kublickiene
Keyword(s):  
Coronary Heart Disease ◽  
Estrogen Receptor ◽  
Heart Disease ◽  
Receptor Subtypes ◽  
Small Arteries
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