scholarly journals Metabolic Activation of Proestrogenic Diphenyl and Related Compounds by Rat Liver Microsomes

2003 ◽  
Vol 49 (4) ◽  
pp. 298-310 ◽  
Author(s):  
Shigeyuki Kitamura ◽  
Seigo Sanoh ◽  
Ryuki Kohta ◽  
Tomoharu Suzuki ◽  
Kazumi Sugihara ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes ◽  
Related Compounds

Metabolic activation of hydralazine by rat liver microsomes

1987 ◽  
Vol 36 (16) ◽  
pp. 2667-2672 ◽  
Author(s):  
Lynn B. LaCagnin ◽  
Howard D. Colby ◽  
Naresh S. Dalal ◽  
John P. O'Donnell
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes

Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: A major role for quinone metabolites

1991 ◽  
Vol 108 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Cathaline den Besten ◽  
Marjan C.C. Smink ◽  
Erik J. de Vries ◽  
Peter J. van Bladeren
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes

Mechanism of metabolic activation of chloroform by rat liver microsomes

1980 ◽  
Vol 29 (24) ◽  
pp. 3271-3276 ◽  
Author(s):  
Lance R. Pohl ◽  
Jackie L. Martin ◽  
John W. George
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes

Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450

1988 ◽  
Vol 9 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Yasushi Yamazoe ◽  
Medhat Abu-Zeid ◽  
Shunichi Manabe ◽  
Seiji Toyama ◽  
Ryuichi Kato
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes ◽  
Cytochrome P 450

INHIBITION OF14C-ESTRONE METABOLISM IN RAT LIVER MICROSOMES BY 2-HYDROXYESTROGENS AND RELATED COMPOUNDS

1965 ◽  
Vol 43 (2) ◽  
pp. 281-290 ◽  
Author(s):  
Catherine Lazier ◽  
P. H. Jellinck
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Structural Features ◽  
Water Soluble ◽  
Rat Liver Microsomes ◽  
Synthetic Estrogen ◽  
Natural Estrogens ◽  
Water Soluble Protein ◽  
Inhibition Studies ◽  
Related Compounds

Inhibition studies with compounds having structural features in common with the natural estrogens have shown that 2-hydroxyestrone and 2-hydroxyestradiol are potent inhibitors of the rat liver microsomal system, which converts estrone to water-soluble protein-bound products. Simple phenols and naphthols hydroxylated in the ortho and para positions were also found to be good inhibitors, but the corresponding meta-hydroxylated compounds, as well as various anthraquinones and estrogens substituted in the 6, 10, or 16 positions, were inactive in this respect. The synthetic estrogen, hexestrol, lost its inhibitory activity on conversion to dihydroxy hexestrol, a nonestrogenic analogue. The type of inhibition produced by 2-hydroxyestrone, equilenin, diethylstilbestrol, and menadione has been determined by the Lineweaver–Burk method and shown to be competitive for the first three of these compounds.

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