scholarly journals Bioactive Constituents from Chinese Natural Medicines. XI. Inhibitors on NO Production and Degranulation in RBL-2H3 from Rubia yunnanensis: Structures of Rubianosides II, III, and IV, Rubianol-g, and Rubianthraquinone

2003 ◽  
Vol 51 (6) ◽  
pp. 654-662 ◽  
Author(s):  
Jing Tao ◽  
Toshio Morikawa ◽  
Shin Ando ◽  
Hisashi Matsuda ◽  
Masayuki Yoshikawa
Keyword(s):  
No Production ◽  
Bioactive Constituents ◽  
Natural Medicines

scholarly journals Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Minh Giang Phan ◽  
Thi Thao Do ◽  
Thi Nga Nguyen ◽  
Thi Viet Huong Do ◽  
Ngoc Phuc Dong ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Human Cancer ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Sesquiterpene Lactones ◽  
No Production ◽  
Bioactive Constituents ◽  
Anti Inflammatory ◽  
First Time ◽  
Eupatorium Japonicum

Eupatorium japonicum Thunb. of the plant family Asteraceae is a popular traditional herb in Vietnam. However, its chemical constituents as well as bioactive principles have not been investigated yet. We investigated the phytochemistry of E. japonicum in Vietnam and isolated seventeen compounds (1–17) including phytosterols, terpenoids, phenolic acids, flavonoids, fatty alcohols, and fatty acids. They were structurally determined by MS and NMR analysis. Except for compounds 6 and 12, all the other compounds were identified for the first time from E. japonicum. Since many sesquiterpene lactones with α-methylene γ-lactone ring are reported as anti-inflammatory and anticancer agents, eupatoriopicrin (10), 1-hydroxy-8-(4,5-dihydroxytigloyloxy)eudesma-4(15),11(13)-dien-6,12-olide (11) were selected among the isolates for biological assays. Compound 10 was identified as the main bioactive sesquiterpene lactone of E. japonicum showing its potent anti-inflammatory and cytotoxic activity through inhibiting NO production and the growth of HepG2 and MCF-7 human cancer cell lines. For the first time, eupatoriopicrin (10) was demonstrated to strongly inhibit NTERA-2 human cancer stem cell (CSC) line in vitro. It is noticeable that the cytotoxicity of eupatoriopicrin against NTERA-2 cells is mediated by its apoptosis-inducing capability of 10 as demonstrated by the results of Hoechst 33342 staining, flow cytometry apoptosis analysis, and caspase-3 activity assays. The biological activities of the main bioactive constituents 1–7, 10, 12, and 15 supported the reported anti-inflammatory and anticancer properties of extracts from E. japonicum.

scholarly journals Bioactive Constituents from Chinese Natural Medicines. XX. Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of Psoralea corylifolia

2007 ◽  
Vol 55 (1) ◽  
pp. 106-110 ◽  
Author(s):  
Hisashi Matsuda ◽  
Sachiko Sugimoto ◽  
Toshio Morikawa ◽  
Koudai Matsuhira ◽  
Eri Mizuguchi ◽  
...  
Keyword(s):  
Psoralea Corylifolia ◽  
Bioactive Constituents ◽  
Natural Medicines

Bioactive Constituents from Chinese Natural Medicines. XXXI. Hepatoprotective Principles from Sinocrassula indica: Structures of Sinocrassosides A8, A9, A10, A11, and A12

Heterocycles ◽  
2008 ◽  
Vol 75 (8) ◽  
pp. 1983 ◽  
Author(s):  
Masayuki Yoshikawa ◽  
Kiyofumi Ninomiya ◽  
Toshio Morikawa ◽  
Haihui Xie ◽  
Hisashi Matsuda
Keyword(s):  
Bioactive Constituents ◽  
Natural Medicines
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