Construction and Performance Characterization of Ion-Selective Electrodes for Potentiometric Determination of Paroxetine Hydrochloride in Pharmaceutical Preparations and Biological Fluids

2014 ◽  
Vol 26 (12) ◽  
pp. 2789-2800 ◽  
Author(s):  
Mohamed M. Khalil ◽  
Yousry M. Issa ◽  
Ali G. Mohamed
Keyword(s):  
Biological Fluids ◽  
Pharmaceutical Preparations ◽  
Potentiometric Determination ◽  
Ion Selective Electrodes ◽  
Performance Characterization ◽  
And Performance ◽  
Paroxetine Hydrochloride

scholarly journals Construction of different types of ion-selective electrodes and validation of direct potentiometric determination of phenytoin sodium

2010 ◽  
Vol 8 (4) ◽  
pp. 937-945 ◽  
Author(s):  
Maha El-Tohamy ◽  
Sawsan Razeq ◽  
Magda El-Maamly ◽  
Abdalla Shalaby
Keyword(s):  
Biological Fluids ◽  
Pharmaceutical Preparations ◽  
Sodium Concentration ◽  
Calibration Graph ◽  
Membrane Composition ◽  
Tungstosilicic Acid ◽  
Phenytoin Sodium ◽  
And Performance ◽  
Ph Range

AbstractThe construction and performance characteristics of phenytoin sodium selective electrodes are detailed. Two types of electrodes: plastic membrane I and coated wire II, were constructed based on the incorporation of phenytoin sodium with tungstosilicic acid. The influence of membrane composition, kind of plasticizer, pH of the test solution, soaking time and the electrodes’ foreign ions were investigated. The electrodes showed a Nernstian response with a mean calibration graph slope of 30.9±0.1 and 28.9±0.1 mV decade−1 at 25°C for electrode I and II respectively, over a phenytoin sodium concentration range of 5×10−3−5×10−6 M and 1×10−3−1×10−6 M with a detection limit 1.3×10−6 M and 2.5×10−7 M for electrode I and II, respectively. The electrodes gave average selective precision and were usable within the pH range 6–10. Interference studies from common cations, alkaloids, sugars, amino acids and drug excipients are reported. The results obtained by the proposed electrodes were also applied successfully for the determination of the drug in pharmaceutical preparations and biological fluids.

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