scholarly journals Nucleosides and Nucleotides. 186. Synthesis and Biological Activities of Pyrimidine Carbocyclic Nucleosides with a Hydroxyamino Group Instead of a Hydroxymethyl Group at the 4'-Position of the Sugar Moiety.

1999 ◽  
Vol 47 (7) ◽  
pp. 1000-1005 ◽  
Author(s):  
Akira OGAWA ◽  
Satoshi SHUTO ◽  
Motohiro TANAKA ◽  
Takuma SASAKI ◽  
Shuji MORI ◽  
...  
Keyword(s):  
Biological Activities ◽  
Carbocyclic Nucleosides ◽  
Hydroxymethyl Group ◽  
Sugar Moiety

scholarly journals New Carbocyclic Nucleosides with a Constrained Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

Proceedings ◽  
2019 ◽  
Vol 29 (1) ◽  
pp. 21
Author(s):  
Constantin I. Tanase ◽  
Constantin Draghici ◽  
Anamaria Hanganu ◽  
Lucia Pintilie ◽  
Maria Maganu ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Carbocyclic Nucleosides ◽  
Sugar Moiety

Nucleosides with a norbornane fragment as sugar moiety (Figure 1) were found to have antiviral and anticancer activity [1]. [...]

ChemInform Abstract: Design, Synthesis, Conformational Analysis and Biological Activities of Purine-Based 1,2-Disubstituted Carbocyclic Nucleosides.

ChemInform ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. no-no
Author(s):  
Carmen Teran ◽  
Lourdes Santana ◽  
Marta Teijeira ◽  
Uriarte Eugenio Uriarte Eugenio ◽  
Erik De Clerq
Keyword(s):  
Conformational Analysis ◽  
Biological Activities ◽  
Carbocyclic Nucleosides ◽  
Design Synthesis

scholarly journals New HSV-1 Anti-Viral 1′-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2446 ◽  
Author(s):  
Tănase ◽  
Drăghici ◽  
Hanganu ◽  
Pintilie ◽  
Maganu ◽  
...  
Keyword(s):  
Chlorine Atom ◽  
Yellow Fever ◽  
Nucleoside Analogs ◽  
Optically Active ◽  
Mitsunobu Reaction ◽  
Hydroxyl Group ◽  
Hydroxymethyl Group ◽  
Sugar Moiety ◽  
Pyrimidine Analogs ◽  
Hsv 1

New 1′-homocarbanucleoside analogs with an optically active substituted bicyclo[2.2.1]heptane skeleton as sugar moiety were synthesized. The pyrimidine analogs with uracil, 5-fluorouracil, thymine and cytosine and key intermediate with 6-chloropurine (5) as nucleobases were synthesized by a selective Mitsunobu reaction on the primary hydroxymethyl group in the presence of 5-endo-hydroxyl group. Adenine and 6-substituted adenine homonucleosides were obtained by the substitution of the 6-chlorine atom of the key intermediate 5 with ammonia and selected amines, and 6-methoxy- and 6-ethoxy substituted purine homonucleosides by reaction with the corresponding alkoxides. No derivatives appeared active against entero, yellow fever, chikungunya, and adeno type 1viruses. Two compounds (6j and 6d) had lower IC50 (15 ± 2 and 21 ± 4 µM) and compound 6f had an identical value of IC50 (28 ± 4 µM) to that of acyclovir, suggesting that the bicyclo[2.2.1]heptane skeleton could be further studied to find a candidate for sugar moiety of the nucleosides.

scholarly journals Design, Synthesis, Conformational Analysis and Biological Activities of Purine-Based 1,2-Di-substituted Carbocyclic Nucleosides.

2000 ◽  
Vol 48 (2) ◽  
pp. 293-295 ◽  
Author(s):  
Carmen TERAN ◽  
Lourdes SANTANA ◽  
Marta TEIJEIRA ◽  
Eugenio URIARTE ◽  
Erik DE CLERCQ
Keyword(s):  
Conformational Analysis ◽  
Biological Activities ◽  
Carbocyclic Nucleosides ◽  
Design Synthesis

scholarly journals Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring

2006 ◽  
Vol 14 (22) ◽  
pp. 7551-7562 ◽  
Author(s):  
Samir Messaoudi ◽  
Fabrice Anizon ◽  
Paul Peixoto ◽  
Marie-Hélène David-Cordonnier ◽  
Roy M. Golsteyn ◽  
...  
Keyword(s):  
Pyridine Ring ◽  
Biological Activities ◽  
Sugar Moiety

scholarly journals Biological activities of chemically synthesized analogues of the nonreducing sugar moiety of lipid A

FEBS Letters ◽  
1984 ◽  
Vol 167 (2) ◽  
pp. 226-230 ◽  
Author(s):  
Motohiro Matsuura ◽  
Yasuhiko Kojima ◽  
J. Yuzuru Homma ◽  
Yoshiyuki Kubota ◽  
Akihiro Yamamoto ◽  
...  
Keyword(s):  
Lipid A ◽  
Biological Activities ◽  
Sugar Moiety

Improvement of cytoprotective and antioxidant activity of Rosa canina L. and Salix alba L. by controlled differential sieving process against H2O2-induced oxidative stress in mouse primary splenocytes

2017 ◽  
Vol 87 (3-4) ◽  
pp. 191-200 ◽  
Author(s):  
Nidhal Soualeh ◽  
Aliçia Stiévenard ◽  
Elie Baudelaire ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Good Alternative ◽  
Activity Levels ◽  
Salix Alba ◽  
Rosa Canina ◽  
Free Process ◽  
Plant Powders ◽  
Sieving Process

Abstract. In this study, cytoprotective and antioxidant activities of Rosa canina (RC) and Salix alba (SA), medicinal plants, were studied on mouse primary splenocytes by comparing Controlled Differential Sieving process (CDSp), which is a novel green solvent-free process, versus a conventional technique, employing hydroethanolic extraction (HEE). Thus, preventive antioxidant activity of three plant powders of homogeneous particle sizes, 50–100 µm, 100–180 µm and 180–315 µm, dissolved directly in the cellular buffer, were compared to those of hydroethanolic (HE) extract, at 2 concentrations (250 and 500 µg/mL) in H2O2-treated spleen cells. Overall, compared to HE extract, the superfine powders, i. e., fractions < 180 µm, at the lowest concentration, resulted in greater reactive oxygen species (ROS) elimination, increased glutathione peroxidase (GPx) activity and lower malondialdehyde (MDA) production. Better antioxidant and preventive effects in pre-treated cells were found with the superfine powders for SA (i. e., 50–100 µm and 100–180 µm, both p < 0.001), and with the intermediate powder for RC (i. e., 100–180 µm, p < 0.05) versus HE extract. The activity levels of catalase (CAT) and superoxide dismutase (SOD) in pretreated splenocytes exposed to H2O2, albeit reduced, were near to those in unexposed cells, suggesting that pretreatment with the fine powders has relatively restored the normal levels of antioxidant-related enzymes. These findings supported that CDSp improved the biological activities of plants, avoiding the use of organic solvents and thus it could be a good alternative to conventional extraction techniques.

Shape‐controlled silver NPs for shape‐dependent biological activities

2017 ◽  
Vol 12 (9) ◽  
pp. 647-651 ◽  
Author(s):  
Fatemeh Sadeghi ◽  
Abolfazl Yazdanpanah ◽  
Amirbabak Abrishamkar ◽  
Fatholah Moztarzadeh ◽  
Arash Ramedani ◽  
...  
Keyword(s):  
Biological Activities ◽  
Silver Nps ◽  
Shape Controlled

Research into chemistry and biological activities of Prangos Lindl. (Apiaceae) species of Turkey

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
KHC Baser ◽  
B Demirci ◽  
G Ozek ◽  
A Duran ◽  
N Tabanca ◽  
...  
Keyword(s):  
Biological Activities
Sign in / Sign up

Export Citation Format

Share Document